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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v16.i6.70
pages 579-583

Methanolic Soluble Fractions of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes) Extract Inhibit Neuraminidase Activity in Newcastle Disease Virus (LaSota)

Bala U. Shamaki
Departments of Veterinary Physiology, Pharmacology, and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria
Umar K. Sandabe
Departments of Veterinary Physiology, Pharmacology, and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria
Adamu O. Ogbe
Department of Animal Science, Faculty of Agriculture, Nassarawa State University, Lafia, Nigeria
Fanna I. Abdulrahman
Department of Chemistry, Faculty of Science, University of Maiduguri, Maiduguri, Nigeria
Abdul-Dahiru El-Yuguda
Animal Virus Research Laboratory, Department of Veterinary Microbiology and Parasitology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria

ABSTRACT

The antineuraminidase activity of different organic soluble fractions of Ganoderma lucidum extract was investigated using inhibition of hemagglutination and elution of chicken erythrocytes by Newcastle disease virus (NDV). Fractions of methanol, ethylacetate, and normal butanol (n-butanol) of the G. lucidum were tested against neuraminidase producing NDV as antigen. Different dilutions of the organic soluble fractions inhibited elution of 1% red blood cells by neuraminidase of NDV While the methanolic and n-butanol extracts inhibited neuraminidase activity even at a dilution of 1:16 and that of ethylacetate fraction inhibited even at 1:32 respectively. This finding indicates that G. lucidum has some antineuraminidase activity against NDV and may be exploited in the management of NDV infection.