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国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushrooms.v16.i6.20
pages 519-528

Safety Assessment of the Royal Sun Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) Intake during Rat Pregnancy

Marli Gerenutti
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, University of Sorocaba, SP, Brazil; Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil; Department of Technological and Environmental Processes, University of Sorocaba, UNISO, Sorocaba, SP, Brazil
Natalia Tribuiani
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Rodovia Raposo Tavares, Sorocaba, SP, Brazil
Bruna Ryzik Oliveira
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Rodovia Raposo Tavares, Sorocaba, SP, Brazil
Raquel Mendonca Rosa-Castro
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Rodovia Raposo Tavares, Sorocaba, SP, Brazil
Italo Frizo
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Rodovia Raposo Tavares, Sorocaba, SP, Brazil
Yoko Oshima-Franco
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Rodovia Raposo Tavares, Sorocaba, SP, Brazil
Denise Grotto
University of Sorocaba

ABSTRACT

In this study, we investigated the reproductive capacity of pregnant rats exposed to daily orally administered powder-dehydrated reconstituted of Agaricus brasiliensis (=Agaricus blazei sensu Murrill), the fetal organogenesis, and the development of the pups. Pregnant rats were exposed for the entire gestational period to water (control) and A. brasiliensis at 300 or 600 mg/kg/day. Fertility and body weight of dams were monitored. Pups were monitored for body weight, offspring vitality, morphology, and physical and neurobehavioral development. An increase in sternebrae agenesis was observed at the 600 mg/kg/day dose of A. brasiliensis, while incomplete ossification of sternebrae was seen even at a 300 mg/kg/day dose. In conclusion, this study is the first to demonstrate the impact of maternal exposure to A. brasiliensis on the fetal organogenesis and development of offspring in a rat model. The 600 mg/kg/day dose showed some negative effects, and low toxicity was observed at the 300 mg/kg/day dose.