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ISSN 打印: 1521-9437

ISSN 在线: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Anti β-Glucan Antibody in Cancer Patients (Preliminary Report)

卷 6, 册 1, 2004, 8 pages
DOI: 10.1615/IntJMedMushr.v6.i1.40
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摘要

CSBG is a β-glucan extracted from Candida albicans and composed mainly of β-1,3 and β-1,6-glucosidic linkages with a small amount of branch. In the preliminary investigation, we have found that human sera from healthy volunteers as well as commercial gamma-globulin preparation significantly reacted with CSBG. In the present study, reactivity of the human sera to CSBG was examined, and specificity of the antibody was examined by various β-glucan fractions from medicinal mushrooms and yeasts. Using CSBG coated ELISA-plate, sera of the normal human volunteers showed higher reactivity, and the reactivity was neutralized by adding soluble CSBG as competitor. Similar specificity was detected in commercially available gamma-globulin prepared from pooled human sera. The β-glucans from Schizosaccharomyces pombe, Agaricus brasiliensis, Penicillium islandicum, and Grifola frondosa were reacted. Comparing the structures with reactivity, the antibody was reacted with β-1,3/-1,6-linked glucose residues, and β-1,6 linkages showed higher reactivity. Isotype of the antibody was mainly IgG. These facts strongly suggested that β-glucans in food, environment, gut flora, as well as pathogenic fungi have continuously stimulated mucosal immune system and enhanced antibody response to β-glucans. To further analyze the clinical meanings of the antibody, the antibody titers in 26 cancer patients were examined and compared with healthy subjects, and the titers significantly varied depending on the condition of the patients. The mechanism of changing antibody titer is not clarified yet; however, monitoring patients with the antibody titer will be a useful diagnostic marker for cancer immune therapy.

对本文的引用
  1. Ohno N., Yeast and Fungal Polysaccharides, in Comprehensive Glycoscience, 2007. Crossref

  2. Ohno Naohito, Fungal Polysaccharides, in Comprehensive Glycoscience, 2021. Crossref

  3. Castro Guillermo R., Panilaitis Bruce, Bora Emilia, Kaplan David L., Controlled Release Biopolymers for Enhancing the Immune Response, Molecular Pharmaceutics, 4, 1, 2007. Crossref

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