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The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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In Vitro Antileishmanial Activity of a Black Morel, Morchella importuna (Ascomycetes)

卷 20, 册 1, 2018, pp. 71-80
DOI: 10.1615/IntJMedMushrooms.2018025313
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摘要

We studied the anti-Leishmania activity of a fractionated extract from the mushroom Morchella importuna in an in vitro system. Leishmaniasis is an important infectious disease caused by a range of Leishmania species, which are multihost protozoa parasites transmitted to humans by the sand fly and infecting macrophages. Leishmaniasis is an increasing worldwide health problem, including in the Mediterranean basin. Current chemotherapy treatments are limited by their toxic effects, the need for long-term treatment, and the increasing development of resistance by the parasite cells. Thus, alternative therapies are being considered, including herbal and mushroom products. We studied the effect of extracts from M. importuna on L. tropica promastigote cell proliferation and survival, and on their toxicity against human macrophages. The aqueous mushroom extract was compared with 3 successive extracted fractions: an 80% ethanol fraction, a water-soluble polysaccharide fraction, and a polyphenolic fraction. All 4 extracts showed anti-Leishmania activity; the aqueous extract was most active. The inhibition activity was dose dependent in killing Leishmania. No cell recovery was recorded after exposure to the mushroom extract. Microscopic observation showed morphological changes and the loss of flagella on the parasites. No cytotoxic activity was recorded against human macrophages at the same extract concentrations. The findings suggest the potential use of extracts of an edible Morchella mushroom against the Leishmania parasite in humans.

对本文的引用
  1. Afrin Farhat, Hemeg Hassan A., Introductory Chapter: Leishmaniasis: An Emerging Clinical Syndrome, in Leishmaniases as Re-emerging Diseases, 2018. Crossref

  2. Li Wan, Cai Zheng-Nan, Mehmood Shomaila, Liang Lin-Lin, Liu Yu, Zhang Hui-Yun, Chen Yan, Lu Yong-Ming, Anti-inflammatory effects of Morchella esculenta polysaccharide and its derivatives in fine particulate matter-treated NR8383 cells, International Journal of Biological Macromolecules, 129, 2019. Crossref

  3. Yang Cailing, Meng Qingfeng, Zhang Yao, Hu Yun, Xiao Shiji, Zhang Yuqian, Ju Jianhua, Fu Shaobin, Morelsins A–F, six sesquiterpenoids from the liquid culture of Morchella importuna, Tetrahedron, 76, 31-32, 2020. Crossref

  4. Peng Dan, Wen Yao, Bi Sixue, Huang Chunhua, Yang Jianing, Guo Zhongyi, Huang Weijuan, Zhu Jianhua, Yu Rongmin, Song Liyan, A new GlcNAc-containing polysaccharide from Morchella importuna fruiting bodies: Structural characterization and immunomodulatory activities in vitro and in vivo, International Journal of Biological Macromolecules, 192, 2021. Crossref

  5. Sambyal Krishika, Singh Rahul Vikram, A comprehensive review on Morchella importuna: cultivation aspects, phytochemistry, and other significant applications, Folia Microbiologica, 66, 2, 2021. Crossref

  6. dos Santos Varjão Márcio Thomaz, Duarte Alysson Wagner Fernandes, Rosa Luiz Henrique, Alexandre-Moreira Magna Suzana, de Queiroz Aline Cavalcanti, Leishmanicidal activity of fungal bioproducts: A systematic review, Fungal Biology Reviews, 40, 2022. Crossref

  7. Vanti Gulamnabi L., Leshem Yehoram, Masaphy Segula, Resistance response enhancement and reduction of Botrytis cinerea infection in strawberry fruit by Morchella conica mycelial extract, Postharvest Biology and Technology, 175, 2021. Crossref

  8. Brioschi Mariana B.C., Coser Elizabeth M., Coelho Adriano C., Gadelha Fernanda R., Miguel Danilo C., Models for cytotoxicity screening of antileishmanial drugs: what has been done so far?, International Journal of Antimicrobial Agents, 60, 2, 2022. Crossref

  9. He Peixin , Chen Zhuo , Men Ying , Wang Miaomiao , Wang Wensheng , Liu Wei , Activity Assay of Amylase and Xylanase Is Available for Quantitative Assessment of Strain Aging in Cultivated Culinary-Medicinal Morchella Mushrooms (Ascomycotina) , International Journal of Medicinal Mushrooms, 25, 1, 2023. Crossref

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