图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
国际药用蘑菇期刊
影响因子: 1.423 5年影响因子: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 打印: 1521-9437
ISSN 在线: 1940-4344

国际药用蘑菇期刊

DOI: 10.1615/IntJMedMushr.v14.i5.90
pages 507-512

Teratogenic and Toxic Effects of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Higher Basidiomycetes), on Zebrafish Embryo as Model

Rich Milton R. Dulay
Center for Tropical Mushroom Research and Development, Central Luzon State University, Science City of Munoz, Nueva Ecija, Philippines
Sofronio P. Kalaw
Center for Tropical Mushroom Research and Development, Central Luzon State University, Science City of Munoz, Nueva Ecija, Philippines ;Department of Biological Sciences, College of Arts and Sciences, Central Luzon State University, Science City of Munoz
Renato G. Reyes
Center for Tropical Mushroom Research and Development, Central Luzon State University, Science City of Munoz, Nueva Ecija, Philippines;Department of Biological Sciences, College of Arts and Sciences, Central Luzon State University, Science City of Munoz,
Noel F. Alfonso
Department of Biology, College of Sciences, De La Salle University, Taft Avenue, Manila, Philippines
Fumio Eguchi
Laboratory of Forest Products Chemistry, Department of Forest Science, Faculty of Regional Environment Science, Tokyo University of Agriculture, 1-1-1, Sakuragaoka, Setagayaku, Tokyo, Japan

ABSTRACT

This paper highlights the teratogenic and toxic effects of Ganoderma lucidum (Lingzhi or Reishi mushroom) extract on zebrafish embryos. Hatchability, malformations, and lethality rate of zebrafish embryos were assessed to provide valuable information regarding the potential teratogenic activity of G. lucidum. Hatching was completed 48 h post treatment application (hpta) at 1% or lower concentrations of extract and embryo water. The hatching rate of embryos treated with 5% or higher concentrations was significantly lower (p> 0.05) than the control. Tail malformation was the most marked morphological abnormality in embryos at 72 hpta, which was obviously caused by 1% extract (55.56% tail malformation) and was observed in all embryos exposed to 5% of extract. Growth retardation was evident in embryos exposed to 5%, 10%, and 20%. However, lethal effect of extract of G. lucidum was dependent on dose and time of exposure. Mortality rates of embryos treated with 5% (44.44%) or higher concentrations of the extract was significantly higher (p > 0.05) than that of the control embryos at 72 hpta. These results suggest that G. lucidum extract has lethal and sub-lethal effects on zebrafish embryos.


Articles with similar content:

Pre- and Postnatal Toxicity of Diazinon Induces Disruption of Spermatogenetic Cell Line Evidenced by Increased Testicular Marker Enzymes Activities in Rat Offspring
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 1
Srinivasa Jayachandra, Urban JA D'Souza
Hydration with Saline Decreases Toxicity of Mice Injected With Calcitriol in Preclinical Studies
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 3
Heather D. Potter, Vivian Lee, KyungMann Kim, Soesiawati R. Darjatmoko, Amir A. Azari, Mozhgan R. Kanavi, Daniel M. Albert
Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): A Species with Antioxidant, Immunomodulatory, and Hepatoprotective Activities in Hypercholesterolemic Rats
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 11
Haseeb Anwar, Jaweria Nisar, Ghulam Hussain, Shazia Anwer Bukhari, Muhammad Naeem Faisal, Muhammad Irfan Ullah, Abdul Basit, Imtiaz Mustafa, Muhammad Umar Sohail
Radioprotection by Oral Administration of Aegle marmelos (L.) Correa In Vivo
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 4
Ponemone Venkatesh, Ganesh Chandra Jagetia
Evaluation of Genotoxicity of Medicinal Plant Extracts by the Comet and VITOTOX® Tests
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 3
Saroj Arora, Swayamjot Kaur, Ethel Brits, Kamaljit Kaur, Subodh Kumar, Luc Verschaeve, Rajbir S. Sohi