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国际生理学与病理学期刊
SJR: 0.116

ISSN 打印: 2155-014X
ISSN 在线: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

国际生理学与病理学期刊

DOI: 10.1615/IntJPhysPathophys.v2.i1.60
pages 55-68

Peculiarities of Changes of Vascular Reactivity and Reactive Forms of Oxygen in Conditions of Varying Duration of Permanent Stay in the Alienation Zone

Mikhail N. Tkachenko
Bogomoletz National Medical University; Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
Anatoliy V. Kotsuruba
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Olga V. Bazilyuk
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Irina V. Gorot
Bogomoletz National Medical University, Kyiv
Vadim F. Sagach
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

ABSTRACT

Changes in the vascular reactivity and in the generation of reactive forms of oxygen and content of stable metabolites of nitric oxide (NO) were studied in the aorta preparations of C57B1/6 and BALB/c mice of the two age groups (6 and 18 mo.), which were born and permanently kept in the Chernobyl alienation zone. The results obtained showed a disturbance of acetylcholine-induced endothelium-dependent reactions of relaxation of smooth muscles of the thoracic aorta. A lower level of oxidative NO synthesis and lower level of nonoxidative arginase metabolism of arginine corresponded to a higher degree of damage of endothelium- dependent reactions of relaxation of the thoracic aorta smooth muscles. A decrease of oxidative NO synthesis in conditions of permanent effects of low doses of radiation was depend on an increase of generation of reactive forms of oxygen, namely, superoxide and hydroxyl radicals, which might be formed in mitochondria. In conditions of permanent effects of low doses of radiation a lesser level of protein nitrosylation, same as lesser one of generation of OH-radical, corresponded to a higher level of damage of endothelium-dependent reactions.