每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
N-myc Downstream-Regulated Gene 1 and Endometriosis: A Minireview
摘要
NDRG1 (N-myc downstream-regulated gene 1) was previously considered to be a differentiation-related gene. However, many other functions of NDRG1 have since been identified, including proliferation, migration, invasion, and vascularization of tumor cells. Currently regarded as a tumor suppressor in most studies, NDRG1 is abundant in prostate, brain, kidney, placental, and intestinal tissues. It is expressed in normal endometrium, with higher expression occurring in the secretory phase. NDRG1 was first identified as an inhibitor of signaling pathways associated with the pathology of endometriosis. The NDRG1 protein regulation of endometriosis is assumed to be associated with several important pathways. This review summarizes the relationship between NDRG1 and endometriosis, focusing on the potential function of NDRG1 in endometriosis through signaling pathways and discusses the additional research that is required for future studies.
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Li Yue, Wang Xiaoyan, Wang Xishuang, Wan Lu, Liu Yanping, Shi Yongyu, Zhang Lining, Fang Zhenghui, Wei Zengtao, PDCD4 suppresses proliferation, migration, and invasion of endometrial cells by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway†, Biology of Reproduction, 99, 2, 2018. Crossref
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Meng Nan, Yang Qian, He Yaping, Gu Wen‐Wen, Gu Yan, Zhen Xing‐Xing, Wang Jianmei, Zhang Xuan, Sun Zhao‐Gui, Wang Jian, Decreased NDRG1 expression is associated with pregnancy loss in mice and attenuates the in vitro decidualization of endometrial stromal cells, Molecular Reproduction and Development, 86, 9, 2019. Crossref
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Lou Tong, Liu Chongdong, Qu Hong, Zhang Zhiqiang, Wang Shuzhen, Zhuang Huiyu, FOXA1 can be modulated by HDAC3 in the progression of epithelial ovarian carcinoma, Journal of Translational Medicine, 20, 1, 2022. Crossref