图书馆订阅: Guest
真核基因表达评论综述™

每年出版 6 

ISSN 打印: 1045-4403

ISSN 在线: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Evolution of Transcriptional Control from Prokaryotic Beginnings to Eukaryotic Complexities

卷 9, 册 3-4, 1999, pp. 175-182
DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.20
Get accessGet access

摘要

Mechanisms for regulating gene transcription became increasingly complex as organisms evolved. In prokaryotes the relatively simple mechanism of repression is based on a few proteins that bind to specific DNA sequences in a ligand-dependent fashion. In eukaryotes large complexes that include ligand binding proteins regulate transcription. Lower eukaryotes developed an additional level of control based on protein complexes that include modifying enzymes. The DNA/histone complex, in combination with gene-specific transcriptional factors, is the basis of gene regulation in eukaryotes. Higher eukaryotes took regulation a level further by methylating CpGs in promoter sequences of DNA, thereby allowing binding of histone deacetylases and inhibiting transcription. Finally, long-lasting "superrepression" provides another mechanism for coordinate transcriptional regulation of large blocks of genes.

对本文的引用
  1. FILIPSKI ALAN, KUMAR SUDHIR, Comparative Genomics in Eukaryotes, in The Evolution of the Genome, 2005. Crossref

  2. Romov Philip A., Li Fubin, Lipke Peter N., Epstein Susan L., Qiu Wei-Gang, Comparative Genomics Reveals Long, Evolutionarily Conserved, Low-Complexity Islands in Yeast Proteins, Journal of Molecular Evolution, 63, 3, 2006. Crossref

  3. Maiolica Alessio, Jünger Martin A., Ezkurdia Iakes, Aebersold Ruedi, Targeted proteome investigation via selected reaction monitoring mass spectrometry, Journal of Proteomics, 75, 12, 2012. Crossref

  4. Huang Lili, Targeting histone deacetylases for the treatment of cancer and inflammatory diseases, Journal of Cellular Physiology, 209, 3, 2006. Crossref

  5. O'Neill Patrick K., Forder Robert, Erill Ivan, Informational Requirements for Transcriptional Regulation, Journal of Computational Biology, 21, 5, 2014. Crossref

  6. Wood Heidi, Fehlner-Gardner Christine, Berry Jody, Fischer Elizabeth, Graham Bonnie, Hackstadt Ted, Roshick Christine, McClarty Grant, Regulation of tryptophan synthase gene expression in Chlamydia trachomatis, Molecular Microbiology, 49, 5, 2003. Crossref

  7. Bruni Luis Emilio, Giorgi Franco, Towards a heterarchical approach to biology and cognition, Progress in Biophysics and Molecular Biology, 119, 3, 2015. Crossref

  8. He Xionglei, Zhang Jianzhi, Gene Complexity and Gene Duplicability, Current Biology, 15, 11, 2005. Crossref

  9. Garcia-Garcia Jose C., de la Fuente José, Blouin Edmour F., Johnson Todd J., Halbur Thomas, Onet Virginia C., Saliki Jeremiah T., Kocan Katherine M., Differential expression of the msp1α gene of Anaplasma marginale occurs in bovine erythrocytes and tick cells, Veterinary Microbiology, 98, 3-4, 2004. Crossref

  10. Saier Milton H., The Bacterial Chromosome, Critical Reviews in Biochemistry and Molecular Biology, 43, 2, 2008. Crossref

  11. Witt Isabell, Kivinen Katja, Käufer Norbert F., Core Promoters in S. pombe: TATA and HomolD Boxes, in The Molecular Biology of Schizosaccharomyces pombe, 2004. Crossref

  12. Messina David N., Glasscock Jarret, Gish Warren, Lovett Michael, An ORFeome-based Analysis of Human Transcription Factor Genes and the Construction of a Microarray to Interrogate Their Expression, Genome Research, 14, 10b, 2004. Crossref

  13. Makova Kateryna D., Li Wen-Hsiung, Divergence in the Spatial Pattern of Gene Expression Between Human Duplicate Genes, Genome Research, 13, 7, 2003. Crossref

  14. Cheng Lixin, Liu Pengfei, Leung Kwong‐Sak, SMILE: a novel procedure for subcellular module identification with localisation expansion, IET Systems Biology, 12, 2, 2018. Crossref

  15. Claverie Jean-Michel, What If There Are Only 30,000 Human Genes?, Science, 291, 5507, 2001. Crossref

  16. Shier Vincent K., Hancey Carey J., Benkovic Stephen J., Identification of the Active Oligomeric State of an Essential Adenine DNA Methyltransferase from Caulobacter crescentus , Journal of Biological Chemistry, 276, 18, 2001. Crossref

  17. Johnson Margaret E., Hummer Gerhard, Nonspecific binding limits the number of proteins in a cell and shapes their interaction networks, Proceedings of the National Academy of Sciences, 108, 2, 2011. Crossref

Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain