图书馆订阅: Guest
真核基因表达评论综述™

每年出版 6 

ISSN 打印: 1045-4403

ISSN 在线: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Does NuMA Have a Scaffold Function in the Interphase Nucleus?

卷 9, 册 3-4, 1999, pp. 319-328
DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.160
Get accessGet access

摘要

We review the properties of NuMA, concentrating on a possible role for NuMA as a scaffold protein in the interphase nucleus. NuMA is a component of the nuclear matrix in interphase cells and translocates to the spindle poles in mitosis. NuMA has a secondary structure in which a long central rod domain that forms a double-stranded coiled coil is flanked by globular terminal domains. In vitro assembly experiments with bacterially expressed recombinant protein showed that NuMA seems not to form filaments, but instead builds multiarm oligomers by interaction of the C-terminal globular domains. Transient overexpression of NuMA in HeLa cells induced the formation of a three-dimensional lattice with a quasihexagonal organization that fills the nucleus. Use of mutant constructs showed that the lattice spacing depended on the length of the rod domain. Using a 12-arm oligomer as the structural unit, computer modeling can explain the observed nuclear lattices. The flexibility of the NuMA molecule as well as its dynamic capacity to form lattices is a hint that NuMA may play a structural role in the architecture of the normal interphase nucleus.

对本文的引用
  1. Mounkes Leslie, Stewart Colin L., , 61, 2004. Crossref

  2. Cassimeris Lynne, Spittle Cynthia, , 210, 2001. Crossref

  3. Heun Patrick, Laroche Thierry, Raghuraman M.K., Gasser Susan M., The Positioning and Dynamics of Origins of Replication in the Budding Yeast Nucleus, Journal of Cell Biology, 152, 2, 2001. Crossref

  4. Razin S. V., Borunova V. V., Iarovaia O. V., Vassetzky Y. S., Nuclear matrix and structural and functional compartmentalization of the eucaryotic cell nucleus, Biochemistry (Moscow), 79, 7, 2014. Crossref

  5. Olins Ada L., Herrmann Harald, Lichter Peter, Kratzmeier Martin, Doenecke Detlef, Olins Donald E., Nuclear Envelope and Chromatin Compositional Differences Comparing Undifferentiated and Retinoic Acid- and Phorbol Ester-Treated HL-60 Cells, Experimental Cell Research, 268, 2, 2001. Crossref

  6. Alvarez Marta, Rhodes Simon J., Bidwell Joseph P., Context-dependent transcription: all politics is local, Gene, 313, 2003. Crossref

  7. Brüning-Richardson Anke, Bond Jaqueline, Alsiary Rawiah, Richardson Julie, Cairns David A., McCormac Luci, Hutson Richard, Burns Philip A., Wilkinson Nafisa, Hall Geoff D., Morrison Ewan E., Bell Sandra M., States J.Christopher, NuMA Overexpression in Epithelial Ovarian Cancer, PLoS ONE, 7, 6, 2012. Crossref

  8. Rose Annkatrin, Gindullis Frank, Meier Iris, A novel alpha‐helical protein, specific to and highly conserved in plants, is associated with the nuclear matrix fraction, Journal of Experimental Botany, 54, 385, 2003. Crossref

  9. Markiewicz Ewa, Dechat Thomas, Foisner Roland, Quinlan Roy. A, Hutchison Christopher J., Lippincott-Schwartz Jennifer, Lamin A/C Binding Protein LAP2α Is Required for Nuclear Anchorage of Retinoblastoma Protein, Molecular Biology of the Cell, 13, 12, 2002. Crossref

  10. Qin Wang-Sen, Wu Jin, Chen Yang, Cui Fa-Cai, Zhang Fu-Ming, Lyu Guan-Ting, Zhang Hong-Mei, The Short Isoform of Nuclear Mitotic Apparatus Protein 1 Functions as a Putative Tumor Suppressor, Chinese Medical Journal, 130, 15, 2017. Crossref

  11. Moreira Pedro N., Robl James M., Collas Philippe, Architectural defects in pronuclei of mouse nuclear transplant embryos, Journal of Cell Science, 116, 18, 2003. Crossref

Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain