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真核基因表达评论综述™
影响因子: 2.156 5年影响因子: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.210
pages 363-371

The Effects of Heat-Shock on Nuclear Matrix-Associated DNA-Replication Complexes

Robert VanderWaal
Mallinckrodt Institute of Radiology, Radiation Oncology Center, Section of Cancer Biology, Washington University School of Medicine, St. Louis, MO 63108
William D. Wright
Mallinckrodt Institute of Radiology, Radiation Oncology Center, Section of Cancer Biology, Washington University School of Medicine, St. Louis, MO 63108
Joseph L. Roti Roti
Mallinckrodt Institute of Radiology, Radiation Oncology Center, Section of Cancer Biology, Washington University School of Medicine, St. Louis, MO 63108

ABSTRACT

To better understand the role of the nuclear matrix in heat-induced cell killing, we have investigated the effects of heat shock on DNA replication complexes. Changes in protein extractability are observed following heat shock, including stabilization of which stabilize DNA replication complexes in association with the nuclear matrix. This situation is accompanied by differential delays in the progress and completion of DNA synthesis and the transition from type I to type II DNA replication patterns. Interestingly, prolonged delays in restarting DNA synthesis produced significant protection from heat-induced cell killing. These results show that nuclear matrix-associated DNA replication complexes may be important targets for heat-induced cell killing.


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