图书馆订阅: Guest
真核基因表达评论综述™

每年出版 6 

ISSN 打印: 1045-4403

ISSN 在线: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Intranuclear Trafficking of Messenger RNA

卷 9, 册 3-4, 1999, pp. 213-219
DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.60
Get accessGet access

摘要

Within the nucleus, protein-encoding genes are transcribed into messenger RNA by RNA polymerase II. Messenger RNAs migrate to the cytoplasm, but before reaching their final destination the primary transcripts must undergo a series of modifications that include 5′-capping, splicing, and 3′-cleavage/polyadenylation. Errors in these processing events can originate aberrant products that, if translated, would produce abnormal proteins. Therefore, it is not surprising that eukaryotes have evolved a surveillance mechanism that recognizes and rapidly degrades aberrant mRNAs. Recent experiments provide exciting insights into how proper mRNAs are distinguished and selected for export. Transcription by RNA polymerase II is directly coupled to pre-mRNA processing, and the mechanism that targets the processing machinery to the polymerase complex suggests a model for co-transcriptional proofreading. Furthermore, there is evidence that at least some mRNAs move randomly throughout the nucleus, presumably by free diffusion. In this light, retention of aberrant mRNAs by the transcription/processing machinery is crucial to prevent their diffusion to the nuclear pores and eventual translocation to the cytoplasm.

对本文的引用
  1. Custódio Noélia, Carmo-Fonseca Maria, Quality control of gene expression in the nucleus, Journal of Cellular and Molecular Medicine, 5, 3, 2001. Crossref

  2. Côté Francine, Boisvert François-Michel, Grondin Benoît, Bazinet Martine, Goodyer Cynthia G., Bazett-Jones David P., Aubry Muriel, Alternative Promoter Usage and Splicing ofZNF74Multifinger Gene Produce Protein Isoforms with a Different Repressor Activity and Nuclear Partitioning, DNA and Cell Biology, 20, 3, 2001. Crossref

  3. Yun Anthony J., Lee Patrick Y., Doux John D., Efficient inefficiency: Biochemical “junk” may represent molecular bridesmaids awaiting emergent function as a buffer against environmental fluctuation, Medical Hypotheses, 67, 4, 2006. Crossref

  4. Schlesinger Jacob, Arama Dina, Noy Hava, Dagash Manar, Belinky Paula, Gross Gideon, In-cell generation of antibody single-chain Fv transcripts by targeted RNA trans-splicing, Journal of Immunological Methods, 282, 1-2, 2003. Crossref

  5. Sabri Nafiseh, Farrants Ann-Kristin Östlund, Hellman Ulf, Visa Neus, Gall Joseph, Evidence for a Posttranscriptional Role of a TFIIICα-like Protein inChironomus tentans, Molecular Biology of the Cell, 13, 5, 2002. Crossref

  6. Hammarskjöld M.-L., Constitutive Transport Element-Mediated Nuclear Export, in Nuclear Export of Viral RNAs, 259, 2001. Crossref

  7. Narayanan Aarthi, Eifert Julia, Marfatia Kavita A., Macara Ian G., Corbett Anita H., Terns Rebecca M., Terns Michael P., Nuclear RanGTP is not required for targeting small nucleolar RNAs to the nucleolus, Journal of Cell Science, 116, 1, 2003. Crossref

Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain