每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
Molecular and Functional Interactions Among Monocytes/Macrophages and Smooth Muscle Cells and Their Relevance for Atherosclerosis
摘要
Macrophages, smooth muscle cells (SMCs), and their interactions have key roles in the pathogenesis of atherosclerotic vascular diseases. In atheroma development, the phenotype of macrophages and SMCs change, which may influence the disease progression. Accumulating data on the phenotypes exhibited by these cells within atherosclerotic lesions raise many questions regarding the mechanisms and factors that might control the transition of cell phenotype. SMCs often reside in vascular lesions in close proximity to macrophage clusters and are most likely influenced by factors released from these proinflammatory phagocytes. Moreover, macrophages may be influenced by direct contact with SMCs or soluble factors released by these cells. Macrophages may promote activation and induce proatherogenic functions of SMCs, and SMCs may modulate macrophage phenotype. Addressing the mechanisms involved in SMC−macrophage crosstalk that lead to phenotypic modulation of both cell types may provide new insight into atherogenesis and new targets for therapies of various vascular diseases.
-
Tan Jin-Yun, Jia Luo-Qi, Shi Wei-Hao, He Qing, Zhu Lei, Yu Bo, Rab5a-mediated autophagy regulates the phenotype and behavior of vascular smooth muscle cells, Molecular Medicine Reports, 14, 5, 2016. Crossref
-
Jia Su-Jie, Gao Ke-Qin, Zhao Ming, Epigenetic regulation in monocyte/macrophage: A key player during atherosclerosis, Cardiovascular Therapeutics, 35, 3, 2017. Crossref
-
Banchhor Sumit K., Londhe Narendra D., Araki Tadashi, Saba Luca, Radeva Petia, Khanna Narendra N., Suri Jasjit S., Calcium detection, its quantification, and grayscale morphology-based risk stratification using machine learning in multimodality big data coronary and carotid scans: A review, Computers in Biology and Medicine, 101, 2018. Crossref
-
Yu Xiao-Hua, Zhang Da-Wei, Zheng Xi-Long, Tang Chao-Ke, C1q tumor necrosis factor-related protein 9 in atherosclerosis: Mechanistic insights and therapeutic potential, Atherosclerosis, 276, 2018. Crossref
-
Zaccagnini Germana, Greco Simona, Longo Marialucia, Maimone Biagina, Voellenkle Christine, Fuschi Paola, Carrara Matteo, Creo Pasquale, Maselli Davide, Tirone Mario, Mazzone Massimiliano, Gaetano Carlo, Spinetti Gaia, Martelli Fabio, Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia, Cell Death & Disease, 12, 5, 2021. Crossref
-
Xiang Pinhao, Blanchard Valentin, Francis Gordon A., Smooth Muscle Cell—Macrophage Interactions Leading to Foam Cell Formation in Atherosclerosis: Location, Location, Location, Frontiers in Physiology, 13, 2022. Crossref