图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
真核基因表达评论综述™
影响因子: 1.841 5年影响因子: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukarGeneExpr.v8.i1.20
pages 19-42

Gene Regulation by Vitamin D3

Carsten Carlberg
Institut fur Physiologische Chemie I, Heinrich-Heine-Universitat Dusseldorf, D-40001 Dusseldorf, Germany
Patsie Polly
Institut fur Physiologische Chemie I, Heinrich-Heine-Universitat Dusseldorf, D-40001 Dusseldorf, Germany

ABSTRACT

The physiologically active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (VD), is a nuclear hormone with pleiotropic action on the control of calcium homeostasis and bone formation, induction of cellular differentiation and apoptosis, inhibition of cellular proliferation, and other cellular signaling processes. The actions of the hormone are mediated by the vitamin D receptor (VDR), a transcription factor that is a nuclear receptor for VD and a member of the nuclear receptor superfamily. The structural relationship between the members of this transcription factor family suggests similar function in DNA binding, transactivation, and contact to other nuclear proteins. However, each nuclear receptor also demonstrates individual properties that are characteristic and not shared by its respective relatives. In this review, both common as well as individual characteristics of VDR-mediated transcriptional regulation are critically discussed.


Articles with similar content:

The ROS-NOX Connection in Cancer and Angiogenesis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.18, 2008, issue 1
Christophe Blanchetot, Johannes Boonstra
Structure-Function Studies of ETS Transcription Factors
Critical Reviews™ in Oncogenesis, Vol.11, 2000, issue 3&4
Murielle Mimeault
Coactivation and Corepression in Transcriptional Regulation by Steroid/Nuclear Hormone Receptors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.8, 1998, issue 2
J. Don Chen, Hui Li
Developmental and Tissue-Specific Regulation of Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Gene Expression
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 2
David Goltzman, John H. White
Parathyroid Hormone-Related Peptide (PTHrP) and Parathyroid Hormone (PTH)/PTHrP Receptor
Critical Reviews™ in Eukaryotic Gene Expression, Vol.8, 1998, issue 3-4
Henry M. Kronenberg, Beate Lanske