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ISSN 打印: 1045-4403

ISSN 在线: 2162-6502

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Indexed in

Gene Regulation by Vitamin D3

卷 8, 册 1, 1998, pp. 19-42
DOI: 10.1615/CritRevEukarGeneExpr.v8.i1.20
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摘要

The physiologically active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (VD), is a nuclear hormone with pleiotropic action on the control of calcium homeostasis and bone formation, induction of cellular differentiation and apoptosis, inhibition of cellular proliferation, and other cellular signaling processes. The actions of the hormone are mediated by the vitamin D receptor (VDR), a transcription factor that is a nuclear receptor for VD and a member of the nuclear receptor superfamily. The structural relationship between the members of this transcription factor family suggests similar function in DNA binding, transactivation, and contact to other nuclear proteins. However, each nuclear receptor also demonstrates individual properties that are characteristic and not shared by its respective relatives. In this review, both common as well as individual characteristics of VDR-mediated transcriptional regulation are critically discussed.

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  110. Penna Giuseppe, Amuchastegui Susana, Giarratana Nadia, Daniel Kenn C., Vulcano Marisa, Sozzani Silvano, Adorini Luciano, 1,25-Dihydroxyvitamin D3 Selectively Modulates Tolerogenic Properties in Myeloid but Not Plasmacytoid Dendritic Cells, The Journal of Immunology, 178, 1, 2007. Crossref

  111. Pascussi Jean-Marc, Vilarem Marie-José, Ostéomalacic consécutive à la prise prolongée de médicaments : sur la piste de PXR, un récepteur impliqué dans la detoxication, médecine/sciences, 21, 6-7, 2005. Crossref

  112. Collins Elaine, Norman Anthony, Vitamin D and Gene Expression, in Nutrient-Gene Interactions in Health and Disease, 20014876, 2001. Crossref

  113. Pascussi J. M., Dvorák Z., Gerbal-Chaloin S., Assenat E., Drocourt L., Maurel P., Vilarem M. J., Regulation of Xenobiotic Detoxification by PXR, CAR, GR, VDR and SHP Receptors: Consequences in Physiology, in Transcription Factors, 166, 2004. Crossref

  114. Giarratana Nadia, Penna Giuseppe, Amuchastegui Susana, Mariani Roberto, Adorini Luciano, Leukocyte migration to pancreatic islets: a critical step in the pathogenesis of type 1 diabetes, in Lymphocyte Trafficking in Health and Disease, 2006. Crossref

  115. Giarratana Nadia, Penna Giuseppe, Gregori Silvia, Daniel Kenn C., Adorini Luciano, Exploiting the potential of regulatory T cells in the control of type 1 diabetes, in Regulatory T Cells in Inflammation, 2005. Crossref

  116. Teichert Arnaud, Bikle Daniel D., Regulation of Keratinocyte Differentiation by Vitamin D and Its Relationship to Squamous Cell Carcinoma, in Signaling Pathways in Squamous Cancer, 2011. Crossref

  117. Tebben Peter J., Singh Ravinder J., Kumar Rajiv, Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment, Endocrine Reviews, 37, 5, 2016. Crossref

  118. Zmijewski Michal A., Carlberg Carsten, Vitamin D receptor(s): In the nucleus but also at membranes?, Experimental Dermatology, 29, 9, 2020. Crossref

  119. Hossain Sharmin, Liu Zhenhua, Wood Richard J, Association between histone deacetylase activity and vitamin D‐dependent gene expressions in relation to sulforaphane in human colorectal cancer cells , Journal of the Science of Food and Agriculture, 101, 5, 2021. Crossref

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  121. Maestro Miguel A., Molnár Ferdinand, Carlberg Carsten, Vitamin D and Its Synthetic Analogs, Journal of Medicinal Chemistry, 62, 15, 2019. Crossref

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  123. WAGNER KAY-DIETRICH, WAGNER NICOLE, SUKHATME VIKAS P., SCHOLZ HOLGER, Activation of Vitamin D Receptor by the Wilms' Tumor GeneProduct Mediates Apoptosis of Renal Cells, Journal of the American Society of Nephrology, 12, 6, 2001. Crossref

  124. Herdick Michaela, Carlberg Carsten, Agonist-triggered Modulation of the Activated and Silent State of the Vitamin D3 Receptor by Interaction with Co-repressors and Co-activators, Journal of Molecular Biology, 304, 5, 2000. Crossref

  125. Dwivedi Prem P., Hii Charles S.T., Ferrante Antonio, Tan Joseph, Der Channing J., Omdahl John L., Morris Howard A., May Brian K., Role of MAP Kinases in the 1,25-Dihydroxyvitamin D3-induced Transactivation of the Rat Cytochrome P450C24 (CYP24) Promoter, Journal of Biological Chemistry, 277, 33, 2002. Crossref

  126. Dong Xiangyang, Craig Theodore, Xing Nianzeng, Bachman Lori A., Paya Carlos V., Weih Falk, McKean David J., Kumar Rajiv, Griffin Matthew D., Direct Transcriptional Regulation of RelB by 1α,25-Dihydroxyvitamin D3 and Its Analogs, Journal of Biological Chemistry, 278, 49, 2003. Crossref

  127. Teichert Arnaud, Arnold Leggy A., Otieno Steve, Oda Yuko, Augustinaite Indre, Geistlinger Tim R., Kriwacki Richard W., Guy R. Kiplin, Bikle Daniel D., Quantification of the Vitamin D Receptor−Coregulator Interaction, Biochemistry, 48, 7, 2009. Crossref

  128. Herdick Michaela, Steinmeyer Andreas, Carlberg Carsten, Antagonistic Action of a 25-Carboxylic Ester Analogue of 1α,25-Dihydroxyvitamin D3 Is Mediated by a Lack of Ligand-induced Vitamin D Receptor Interaction with Coactivators, Journal of Biological Chemistry, 275, 22, 2000. Crossref

  129. Griffin Matthew D., Xing Nianzeng, Kumar Rajiv, VITAMIN D AND ITS ANALOGS AS REGULATORS OF IMMUNE ACTIVATION AND ANTIGEN PRESENTATION, Annual Review of Nutrition, 23, 1, 2003. Crossref

  130. Hussain Alamgir M.M., Lee Hon Cheung, Chang Chan Fong, Modulation of CD157 expression in multi-lineage myeloid differentiation of promyelocytic cell lines, European Journal of Cell Biology, 79, 10, 2000. Crossref

  131. Beck Laurent, Markovich Daniel, The Mouse Na+-Sulfate Cotransporter GeneNas1, Journal of Biological Chemistry, 275, 16, 2000. Crossref

  132. Carlberg Carsten, Vitamin D and Its Target Genes, Nutrients, 14, 7, 2022. Crossref

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  134. Saramäki Anna, Diermeier Sarah, Kellner Ruth, Laitinen Heidi, Vaïsänen Sami, Carlberg Carsten, Cyclical Chromatin Looping and Transcription Factor Association on the Regulatory Regions of the p21 (CDKN1A) Gene in Response to 1α,25-Dihydroxyvitamin D3, Journal of Biological Chemistry, 284, 12, 2009. Crossref

  135. Qiu Fubin, Li Rui, Gu Siyu, Zhao Yimin, Yang Linxue, The effect of iron dextran on vitamin D3 metabolism in SD rats, Nutrition & Metabolism, 19, 1, 2022. Crossref

  136. Alsufiani Hadeil M., AlGhamdi Shareefa A., AlShaibi Huda F., Khoja Sawsan O., Saif Safa F., Carlberg Carsten, A Single Vitamin D3 Bolus Supplementation Improves Vitamin D Status and Reduces Proinflammatory Cytokines in Healthy Females, Nutrients, 14, 19, 2022. Crossref

  137. Carlberg Carsten, Target Genes of Vitamin D, in Vitamin D, 2011. Crossref

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