每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
Gene Regulation by Vitamin D3
摘要
The physiologically active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (VD), is a nuclear hormone with pleiotropic action on the control of calcium homeostasis and bone formation, induction of cellular differentiation and apoptosis, inhibition of cellular proliferation, and other cellular signaling processes. The actions of the hormone are mediated by the vitamin D receptor (VDR), a transcription factor that is a nuclear receptor for VD and a member of the nuclear receptor superfamily. The structural relationship between the members of this transcription factor family suggests similar function in DNA binding, transactivation, and contact to other nuclear proteins. However, each nuclear receptor also demonstrates individual properties that are characteristic and not shared by its respective relatives. In this review, both common as well as individual characteristics of VDR-mediated transcriptional regulation are critically discussed.
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Lutz Ward, Burritt Mary F., Nixon David E., Kao Pai Chih, Kumar Rajiv, Zinc Increases the Activity of Vitamin D-Dependent Promoters in Osteoblasts, Biochemical and Biophysical Research Communications, 271, 1, 2000. Crossref
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Herdick Michaela, Steinmeyer Andreas, Carlberg Carsten, Carboxylic ester antagonists of 1α,25-dihydroxyvitamin D3 show cell-specific actions, Chemistry & Biology, 7, 11, 2000. Crossref
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Malinen Marjo, Ryynänen Jussi, Heinäniemi Merja, Väisänen Sami, Carlberg Carsten, Cyclical regulation of the insulin-like growth factor binding protein 3 gene in response to 1α,25-dihydroxyvitamin D 3, Nucleic Acids Research, 39, 2, 2011. Crossref
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Sertznig Pit, Seifert Markus, Tilgen Wolfgang, Reichrath Jörg, Activation of vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling pathways through 1,25(OH)2D3in melanoma cell lines and other skin-derived cell lines, Dermato-Endocrinology, 1, 4, 2009. Crossref
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Väisänen Sami, Peräkylä Mikael, Kärkkäinen Jouni I, Steinmeyer Andreas, Carlberg Carsten, Critical role of helix 12 of the vitamin D 3 receptor for the partial agonism of carboxylic ester antagonists 1 1Edited by R. Huber, Journal of Molecular Biology, 315, 2, 2002. Crossref
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Segaert Siegfried, Garmyn Marjan, Degreef Hugo, Bouillon Roger, Suppression of Vitamin D Receptor and Induction of Retinoid X Receptor α Expression During Squamous Differentiation of Cultured Keratinocytes, Journal of Investigative Dermatology, 114, 3, 2000. Crossref
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Väisänen Sami, Matilainen Juha, Carlberg Carsten, Dynamic nature of transcriptional regulation of nuclear receptor target genes in the context of chromatin organization, Dermato-Endocrinology, 3, 3, 2011. Crossref
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ADORINI LUCIANO, Regulation of Immune Responses by Vitamin D Receptor Ligands, in Vitamin D, 2005. Crossref
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Quack Marcus, Carlberg Carsten, Ligand-triggered stabilization of vitamin D Receptor/Retinoid X receptor heterodimer conformations on DR4-type response elements, Journal of Molecular Biology, 296, 3, 2000. Crossref
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CARLBERG CARSTEN, DUNLOP THOMAS W., FRANK CHRISTIAN, VÄISÄNEN SAMI, Molecular Basis of the Diversity of Vitamin D Target Genes, in Vitamin D, 2005. Crossref
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Ishizuka Seiichi, Miura Daishiro, Ozono Keiichi, Saito Mariko, Eguchi Hiroshi, Chokki Manabu, Norman Anthony W, (23S)- and (23R)-25-dehydro-1α-hydroxyvitamin D3-26,23-lactone function as antagonists of vitamin D receptor-mediated genomic actions of 1α,25-dihydroxyvitamin D3, Steroids, 66, 3-5, 2001. Crossref
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Carlberg Carsten, Quack Marcus, Herdick Michaela, Bury Yvonne, Polly Patsie, Toell Andrea, Central role of VDR conformations for understanding selective actions of vitamin D3 analogues, Steroids, 66, 3-5, 2001. Crossref
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Frank Christian, Makkonen Harri, Dunlop Thomas W., Matilainen Merja, Väisänen Sami, Carlberg Carsten, Identification of Pregnane X Receptor Binding Sites in the Regulatory Regions of Genes Involved in Bile Acid Homeostasis, Journal of Molecular Biology, 346, 2, 2005. Crossref
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Peehl Donna M., Shinghal Rajesh, Nonn Larisa, Seto Eugene, Krishnan Aruna V., Brooks James D., Feldman David, Molecular activity of 1,25-dihydroxyvitamin D3 in primary cultures of human prostatic epithelial cells revealed by cDNA microarray analysis, The Journal of Steroid Biochemistry and Molecular Biology, 92, 3, 2004. Crossref
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Lim Joan Hui Juan, Ravikumar Sharada, Wang Yan-Ming, Thamboo Thomas Paulraj, Ong Lizhen, Chen Jinmiao, Goh Jessamine Geraldine, Tay Sen Hee, Chengchen Lufei, Win Mar Soe, Leong Winnie, Lau Titus, Foo Roger, Mirza Haris, Tan Kevin Shyong Wei, Sethi Sunil, Khoo Ai Leng, Chng Wee Joo, Osato Motomi, Netea Mihai G., Wang Yue, Chai Louis Yi Ann, Bimodal Influence of Vitamin D in Host Response to SystemicCandidaInfection—Vitamin D Dose Matters, Journal of Infectious Diseases, 212, 4, 2015. Crossref
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Pike J. Wesley, Watanuki Makoto, Shevde Nirupama K., Vitamin D3: Synthesis, Actions, and Mechanisms in the Intestine and Colon, in Physiology of the Gastrointestinal Tract, 2006. Crossref
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Zhang Yong-guo, Wu Shaoping, Lu Rong, Zhou David, Zhou Jingsong, Carmeliet Geert, Petrof Elaine, Claud Erika C., Sun Jun, Tight junction CLDN2 gene is a direct target of the vitamin D receptor, Scientific Reports, 5, 1, 2015. Crossref
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Väisänen Sami, Dunlop Thomas W., Frank Christian, Carlberg Carsten, Using chromatin immunoprecipitation to monitor 1α,25-dihydroxyvitamin D3-dependent chromatin activity on the human CYP24 promoter, The Journal of Steroid Biochemistry and Molecular Biology, 89-90, 2004. Crossref
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Carlberg Carsten, Ligand-mediated conformational changes of the VDR are required for gene transactivation, The Journal of Steroid Biochemistry and Molecular Biology, 89-90, 2004. Crossref
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Dunlop Thomas W., Väisänen Sami, Frank Christian, Carlberg Carsten, The genes of the coactivator TIF2 and the corepressor SMRT are primary 1α,25(OH)2D3 targets, The Journal of Steroid Biochemistry and Molecular Biology, 89-90, 2004. Crossref
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Väisänen Sami, Dunlop Thomas W., Sinkkonen Lasse, Frank Christian, Carlberg Carsten, Spatio-temporal Activation of Chromatin on the Human CYP24 Gene Promoter in the Presence of 1α,25-Dihydroxyvitamin D3, Journal of Molecular Biology, 350, 1, 2005. Crossref
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Toropainen Sari, Väisänen Sami, Heikkinen Sami, Carlberg Carsten, The Down-regulation of the Human MYC Gene by the Nuclear Hormone 1α,25-dihydroxyvitamin D3 is Associated with Cycling of Corepressors and Histone Deacetylases, Journal of Molecular Biology, 400, 3, 2010. Crossref
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Dunlop Thomas W., Väisänen Sami, Frank Christian, Molnár Ferdinand, Sinkkonen Lasse, Carlberg Carsten, The Human Peroxisome Proliferator-activated Receptor δ Gene is a Primary Target of 1α,25-Dihydroxyvitamin D3 and its Nuclear Receptor, Journal of Molecular Biology, 349, 2, 2005. Crossref
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Moravej Ali, Karimi Mohammad-Hossein, Geramizadeh Bita, Azarpira Negar, Zarnani Amir-Hasan, Yaghobi Ramin, Khosravi Maryam, Kalani Mehdi, Gharesi-Fard Behrouz, Mesenchymal Stem Cells Upregulate the Expression of PD-L1 But Not VDR in Dendritic Cells, Immunological Investigations, 46, 1, 2017. Crossref
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Ishikawa Larissa Lumi Watanabe, Colavite Priscila Maria, Fraga-Silva Thais Fernanda de Campos, Mimura Luiza Ayumi Nishiyama, França Thais Graziela Donegá, Zorzella-Pezavento Sofia Fernanda Gonçalves, Chiuso-Minicucci Fernanda, Marcolino Larissa Doddi, Penitenti Marcimara, Ikoma Maura Rosane Valerio, Sartori Alexandrina, Vitamin D Deficiency and Rheumatoid Arthritis, Clinical Reviews in Allergy & Immunology, 52, 3, 2017. Crossref
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Matilainen Juha M., Malinen Marjo, Turunen Mikko M., Carlberg Carsten, Väisänen Sami, The Number of Vitamin D Receptor Binding Sites Defines the Different Vitamin D Responsiveness of the CYP24 Gene in Malignant and Normal Mammary Cells, Journal of Biological Chemistry, 285, 31, 2010. Crossref
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Quack Marcus, Frank Christian, Carlberg Carsten, Differential nuclear receptor signalling from DR4-type response elements, Journal of Cellular Biochemistry, 86, 3, 2002. Crossref
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Gombart Adrian F., Borregaard Niels, Koeffler H. Phillip, Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D 3 , The FASEB Journal, 19, 9, 2005. Crossref
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Danielsson Carina, T�rm� Hans, Vahlquist Anders, Carlberg Carsten, Positive and negative interaction of 1,25-dihydroxyvitamin D3 and the retinoid CD437 in the induction of human melanoma cell apoptosis, International Journal of Cancer, 81, 3, 1999. Crossref
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Polly Patsie, Herdick Michaela, Moehren Udo, Baniahmad Aria, Heinzel Thorsten, Carlberg Carsten, VDR‐Alien: a novel, DNA‐selective vitamin D3receptor‐corepressor partnership, The FASEB Journal, 14, 10, 2000. Crossref
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Lefebvre d'Hellencourt Christian, Montero-Menei Claudia N., Bernard Rozenn, Couez Dominique, Vitamin D3 inhibits proinflammatory cytokines and nitric oxide production by the EOC13 microglial cell line, Journal of Neuroscience Research, 71, 4, 2003. Crossref
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Pike J. Wesley, Lee Seong M., Meyer Mark B., The Vitamin D System: Biological and Molecular Actions in the Intestine and Colon, in Physiology of the Gastrointestinal Tract, 2018. Crossref
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Peehl Donna M., Krishnan Aruna V., Feldman David, Pathways Mediating the Growth-Inhibitory Actions of Vitamin D in Prostate Cancer, The Journal of Nutrition, 133, 7, 2003. Crossref
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Norman Anthony W., 1 α ,25(OH) 2 Vitamin D 3, in Principles of Bone Biology, 2002. Crossref
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Feigerlova Eva, Demarquet Lea, Melhem Hassan, Ghemrawi Rose, Battaglia‐Hsu Shyue‐Fang, Ewu Essi, Alberto Jean‐Marc, Helle Deborah, Weryha Georges, Guéant Jean‐Louis, Methyl donor deficiency impairs bone developmentviaperoxisome proliferator‐activated receptor‐γ coactivator‐1α–dependent vitamin D receptor pathway, The FASEB Journal, 30, 10, 2016. Crossref
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Toell Andrea, Gonzalez Manuel Macias, Ruf Dagmar, Steinmeyer Andreas, Ishizuka Seiichi, Carlberg Carsten, Different Molecular Mechanisms of Vitamin D3 Receptor Antagonists, Molecular Pharmacology, 59, 6, 2001. Crossref
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Carlberg Carsten, New Insights to Nuclear Receptor Gene Regulation from Analysis of their Response Elements in Target Genes, in Nuclear Receptors, 2010. Crossref
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Giarratana Nadia, Penna Giuseppe, Amuchastegui Susana, Mariani Roberto, Daniel Kenn C., Adorini Luciano, A Vitamin D Analog Down-Regulates Proinflammatory Chemokine Production by Pancreatic Islets Inhibiting T Cell Recruitment and Type 1 Diabetes Development, The Journal of Immunology, 173, 4, 2004. Crossref
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Carlberg Carsten, Diversity of Vitamin D Target Genes, in Vitamin D, 2010. Crossref
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Mathieu Chantal, Gysemans Conny, Giulietti Annapaula, Overbergh Lut, Verstuyf Annemieke, Van Etten Evelyne, Regulation of Cytokines and Immune Function by 1,25-Dihydroxyvitamin D3 and Its Analogs, in Nutrients and Cell Signaling, 20054619, 2005. Crossref
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Carlberg Carsten, Current Understanding of the Function of the Nuclear Vitamin D Receptor in Response to Its Natural and Synthetic Ligands, in Vitamin D Analogs in Cancer Prevention and Therapy, 164, 2003. Crossref
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Väisänen Sami, Peräkylä Mikael, Kärkkäinen Jouni I., Uskokovic Milan R., Carlberg Carsten, Structural Evaluation of the Agonistic Action of a Vitamin D Analog with Two Side Chains Binding to the Nuclear Vitamin D Receptor, Molecular Pharmacology, 63, 6, 2003. Crossref
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Ochiai Eiji, Miura Daishiro, Eguchi Hiroshi, Ohara Sachiko, Takenouchi Kazuya, Azuma Yoshiaki, Kamimura Takashi, Norman Anthony W., Ishizuka Seiichi, Molecular Mechanism of the Vitamin D Antagonistic Actions of (23S)-25-Dehydro-1α-Hydroxyvitamin D3-26,23-Lactone Depends on the Primary Structure of the Carboxyl-Terminal Region of the Vitamin D Receptor, Molecular Endocrinology, 19, 5, 2005. Crossref
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Burnstein Kerry L., Antiproliferative Effect of Vitamin D in Prostate Epithelial Cells, in Steroid Hormones and Cell Cycle Regulation, 2002. Crossref
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Gauzzi Maria Cristina, Purificato Cristina, Donato Karim, Jin Yixin, Wang Ling, Daniel Kenn C., Maghazachi Azzam A., Belardelli Filippo, Adorini Luciano, Gessani Sandra, Suppressive Effect of 1α,25-Dihydroxyvitamin D3on Type I IFN-Mediated Monocyte Differentiation into Dendritic Cells: Impairment of Functional Activities and Chemotaxis, The Journal of Immunology, 174, 1, 2005. Crossref
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Bury Yvonne, Steinmeyer Andreas, Carlberg Carsten, Structure Activity Relationship of Carboxylic Ester Antagonists of the Vitamin D3 Receptor, Molecular Pharmacology, 58, 5, 2000. Crossref
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Penna Giuseppe, Amuchastegui Susana, Giarratana Nadia, Daniel Kenn C., Vulcano Marisa, Sozzani Silvano, Adorini Luciano, 1,25-Dihydroxyvitamin D3 Selectively Modulates Tolerogenic Properties in Myeloid but Not Plasmacytoid Dendritic Cells, The Journal of Immunology, 178, 1, 2007. Crossref
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Pascussi Jean-Marc, Vilarem Marie-José, Ostéomalacic consécutive à la prise prolongée de médicaments : sur la piste de PXR, un récepteur impliqué dans la detoxication, médecine/sciences, 21, 6-7, 2005. Crossref
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Giarratana Nadia, Penna Giuseppe, Amuchastegui Susana, Mariani Roberto, Adorini Luciano, Leukocyte migration to pancreatic islets: a critical step in the pathogenesis of type 1 diabetes, in Lymphocyte Trafficking in Health and Disease, 2006. Crossref
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Giarratana Nadia, Penna Giuseppe, Gregori Silvia, Daniel Kenn C., Adorini Luciano, Exploiting the potential of regulatory T cells in the control of type 1 diabetes, in Regulatory T Cells in Inflammation, 2005. Crossref
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Teichert Arnaud, Bikle Daniel D., Regulation of Keratinocyte Differentiation by Vitamin D and Its Relationship to Squamous Cell Carcinoma, in Signaling Pathways in Squamous Cancer, 2011. Crossref
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Carlberg Carsten, Target Genes of Vitamin D, in Vitamin D, 2011. Crossref