每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
Function, Significance, and Regulation of Rap1b in Malignancy
摘要
Ras-associated protein 1(Rap1) is a member of the RAS family of small G proteins and regulates several signal pathways involved in carcinogenesis. Rap1 consists of two highly homologous isoforms, Rap1a and Rap1b. Increasing data suggest that the deregulated activation of Rap1b is involved in a spectrum of malignancies. Accumulating evidence also indicates effects of Rap1b on cell proliferation, metastasis, angiogenesis, and treatment resistance. Rap1b overexpresses in many tumors and has prognostic values, which are regulated by A2br, miRNAs, and other upstream effectors. This article aims to review research progress in function, significance, and regulation of Rap1b in malignancy.
-
Yao Jie, Wang Zefen, Cheng Yong, Ma Chao, Zhong Yahua, Xiao Yilei, Gao Xu, Li Zhiqiang, M2 macrophage-derived exosomal microRNAs inhibit cell migration and invasion in gliomas through PI3K/AKT/mTOR signaling pathway, Journal of Translational Medicine, 19, 1, 2021. Crossref
-
Hinz Sonja, Jung Dominik, Hauert Dorota, Bachmann Hagen S., Molecular and Pharmacological Characterization of the Interaction between Human Geranylgeranyltransferase Type I and Ras-Related Protein Rap1B, International Journal of Molecular Sciences, 22, 5, 2021. Crossref
-
Xu Cong, Fu Yunfeng, Expression Profiles of tRNA-Derived Fragments and Their Potential Roles in Multiple Myeloma, OncoTargets and Therapy, Volume 14, 2021. Crossref
-
Wang Limin, Song Xinghua, Yu Lijun, Liu Bing, Ma Jinfeng, Yang Weihua, Villar Victor H., LINC00665 Facilitates the Malignant Processes of Osteosarcoma by Increasing the RAP1B Expression via Sponging miR-708 and miR-142-5p, Analytical Cellular Pathology, 2021, 2021. Crossref
-
Perez-Bacho Eduardo Gil, Beltrán-Anaya Fredy Omar, Arechaga-Ocampo Elena, Hernández-Sotelo Daniel, Garibay-Cerdenares Olga Lilia, Illades-Aguiar Berenice, Alarcón-Romero Luz Del Carmen, Del Moral-Hernández Oscar, The E6 Oncoprotein of HPV16 AA-c Variant Regulates Cell Migration through the MINCR/miR-28-5p/RAP1B Axis, Viruses, 14, 5, 2022. Crossref
-
Singh Bandana, Kosuru Ramoji, Lakshmikanthan Sribalaji, Sorci-Thomas Mary G., Zhang David X., Sparapani Rodney, Vasquez-Vivar Jeannette, Chrzanowska Magdalena, Endothelial Rap1 (Ras-Association Proximate 1) Restricts Inflammatory Signaling to Protect From the Progression of Atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology, 41, 2, 2021. Crossref
-
Li Wang-shu, Li Yi-lin, Cao Rui, Ha Chun-fang, Sun Shu, Yu Lan, Li Jian, Sehirli Ahmet Özer, Differential Expression and Bioinformatics Analysis of tRF/tiRNA in Endometriosis Patients, BioMed Research International, 2022, 2022. Crossref
-
Zhang Peng, Huang Lingling, Ma Pengwei, Niu Xiaoying, Altered Expressions of NF1 and NF1-Related microRNAs as Biomarkers in the Diagnosis of Undifferentiated Pleomorphic Sarcoma, Frontiers in Genetics, 13, 2022. Crossref
-
Liu Zhe, Yang Yuan, Ju Jihui, Zhang Guangliang, Zhang Ping, Ji Pengxiang, Jin Qianheng, Cao Gaobiao, Zuo Rui, Wang Hongyu, Yu Chenghao, Zhang Zhiqiang, Le Yingying, Fu Yi, Hou Ruixing, Marchese Cinzia, miR-100-5p Promotes Epidermal Stem Cell Proliferation through Targeting MTMR3 to Activate PIP3/AKT and ERK Signaling Pathways, Stem Cells International, 2022, 2022. Crossref
-
Cui Guoliang, Wang Can, Lin Zhenyan, Feng Xiaoke, Wei Muxin, Miao Zhengyue, Sun Zhiguang, Wei Fei, Prognostic and immunological role of Ras-related protein Rap1b in pan-cancer, Bioengineered, 12, 1, 2021. Crossref
-
Chen Shuo, Li Qian‐hui, Chen Xi, Bao Hai‐Juan, Wu Wu, Shen Fan, Lu Bing‐Feng, Jiang Ru‐Qi, Zong Zhi‐hong, Zhao Yang, SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP , Journal of Cellular and Molecular Medicine, 26, 20, 2022. Crossref
-
Park Soo Kyung, Kim Sung-Won, Seo Hwi Won, Hyun Sun Hee, Kyung Jong-Su, Youn Soo-Hyun, So Seung Ho, In Gyo, Park Chae-Kyu, Yi Eugene C., Han Chang-Kyun, Lee Yong Yook, Long-term evaluation of safety and biological effects of Korean Red Ginseng (Panax Ginseng): a long-term in vivo study, BMC Complementary Medicine and Therapies, 22, 1, 2022. Crossref