每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
Expression of the BMP 2 Gene during Bone Cell Differentiation
摘要
Bone morphogenetic protein 2 (BMP 2) and transforming growth factor β (TGFβ) are actively involved in bone formation and remodeling. TGFβ, a powerful stimulant in the early stage of bone cell growth and matrix formation, inhibits differentiation and in vitro mineralized nodule formation in primary fetal rat calvarial osteoblast system. TGFβ also negatively regulates BMP 2 expression at the transcriptional level. BMP 2 gene expression is controlled by a battery of transcriptional factors, some known and some yet to be identified. Immortalized osteoblast cell lines generated from a transgenic mouse carrying BMP 2 promoter-driven SV40 large T antigen transgene are described as powerful tools for studying regulation of BMP 2 gene expression and bone cell differentiation at the molecular level.
-
Melissa Alsina, Guise Theresa A., G. David Roodman, Cytokine Regulation of Bone Cell Differentiation, in Advances in Research and Applications, 52, 1996. Crossref
-
Zhang Rongrong, Oyajobi Babatunde O., Harris Stephen E., Chen Di, Tsao Christopher, Deng Hong-Wen, Zhao Ming, Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts, Bone, 52, 1, 2013. Crossref
-
Canalis Ernesto, Skeletal Growth Factors, in Fundamentals of Osteoporosis, 2010. Crossref
-
Saito Kan, Konishi Ikuri, Nishiguchi Miyuki, Hoshino Tomonori, Fujiwara Taku, Amelogenin binds to both heparan sulfate and bone morphogenetic protein 2 and pharmacologically suppresses the effect of noggin, Bone, 43, 2, 2008. Crossref
-
Mundy Gregory R., Oyajobi Babatunde, Gutierrez Gloria, Sterling Julie, Padalecki Susan, Elefteriou Florent, Zhao Ming, Cytokines and Bone Remodeling, in Fundamentals of Osteoporosis, 2010. Crossref
-
Marie Pierre J., Osteoblasts and Bone Formation, in Molecular and Cellular Biology of Bone, 5, 1998. Crossref
-
Fitzgerald Katherine A., O'Neill Luke A.J., Gearing Andy J.H., Callard Robin E., BMPs, in The Cytokine FactsBook and Webfacts, 2001. Crossref
-
Chandar Nalini, Swindle John, Szajkovics Ann, Kolman Kevin, Relationship of bone morphogenetic protein expression during osteoblast differentiation to wild type p53, Journal of Orthopaedic Research, 23, 6, 2005. Crossref
-
Pereira Renata C., Rydziel Sheila, Canalis Ernesto, Bone morphogenetic protein-4 regulates its own expression in cultured osteoblasts, Journal of Cellular Physiology, 182, 2, 2000. Crossref
-
Canalis Ernesto, Skeletal Growth Factors, in Osteoporosis, 2013. Crossref
-
CHOLE RICHARD A., The Molecular Biology of Bone Resorption Due to Chronic Otitis Media, Annals of the New York Academy of Sciences, 830, 1 Immunologic D, 1997. Crossref
-
Hefferan Theresa E., Subramaniam M., Khosla Sundeep, Riggs B. Lawrence, Spelsberg Thomas C., Cytokine-specific induction of the TGF-? inducible early gene (TIEG): Regulation by specific members of the TGF-? family, Journal of Cellular Biochemistry, 78, 3, 2000. Crossref
-
Hay Eric, Hott Monique, Graulet Anne-Marie, Lomri Abderrahim, Marie Pierre J., Effects of bone morphogenetic protein-2 on human neonatal calvaria cell differentiation, Journal of Cellular Biochemistry, 72, 1, 1999. Crossref
-
Majeska Robert, Cell Biology of Bone, in Bone Mechanics Handbook, Second Edition, 2001. Crossref
-
Agas Dimitrios, Sabbieti Maria Giovanna, Marchetti Luigi, Xiao Liping, Hurley Marja M., FGF-2 enhances Runx-2/Smads nuclear localization in BMP-2 canonical signaling in osteoblasts, Journal of Cellular Physiology, 228, 11, 2013. Crossref
-
Sanyal Arunik, Sarkar Gobinda, Saris Daniel B. F., Fitzsimmons James S., Bolander Mark E., O'Driscoll Shawn W., Initial evidence for the involvement of bone morphogenetic protein-2 early during periosteal chondrogenesis, Journal of Orthopaedic Research, 17, 6, 1999. Crossref
-
Rhee Samuel T., El-Bassiony Loai, Buchman Steven R., Extracellular Signal-Related Kinase and Bone Morphogenetic Protein Expression during Distraction Osteogenesis of the Mandible: In Vivo Evidence of a Mechanotransduction Mechanism for Differentiation and Osteogenesis by Mesenchymal Precursor Cells, Plastic and Reconstructive Surgery, 117, 7, 2006. Crossref
-
Carreira Ana Claudia, Alves Gutemberg Gomes, Zambuzzi William Fernando, Sogayar Mari Cleide, Granjeiro José Mauro, Bone Morphogenetic Proteins: Structure, biological function and therapeutic applications, Archives of Biochemistry and Biophysics, 561, 2014. Crossref
-
Ghosh-Choudhury Nandini, Ghosh Choudhury Goutam, Harris Marie A., Wozney John, Mundy Gregory R., Abboud Sherry L., Harris Stephen E., Autoregulation of Mouse BMP-2 Gene Transcription Is Directed by the Proximal Promoter Element, Biochemical and Biophysical Research Communications, 286, 1, 2001. Crossref
-
Deregowski Valerie, Gazzerro Elisabetta, Priest Leah, Rydziel Sheila, Canalis Ernesto, Role of the Ram Domain and Ankyrin Repeats on Notch Signaling and Activity in Cells of Osteoblastic Lineage, Journal of Bone and Mineral Research, 21, 8, 2006. Crossref
-
Xiao Guozhi, Gopalakrishnan Rajaram, Jiang Di, Reith Elizabeth, Benson M. Douglas, Franceschi Renny T., Bone Morphogenetic Proteins, Extracellular Matrix, and Mitogen-Activated Protein Kinase Signaling Pathways Are Required for Osteoblast-Specific Gene Expression and Differentiation in MC3T3-E1 Cells, Journal of Bone and Mineral Research, 17, 1, 2002. Crossref
-
van den Dolder Juliette, de Ruijter Anja J.E., Spauwen Paul H.M., Jansen John A., Observations on the effect of BMP-2 on rat bone marrow cells cultured on titanium substrates of different roughness, Biomaterials, 24, 11, 2003. Crossref
-
Bonewald Lynda F., Dallas Sarah L., The Role of Growth Factors in Bone Formation, in Molecular and Cellular Biology of Bone, 5, 1998. Crossref
-
CANALIS ERNESTO, Skeletal Growth Factors, in Osteoporosis, 2008. Crossref
-
MUNDY GREGORY R., OYAJOBI BABATUNDE, GUTIERREZ GLORIA, STERLING JULIE, PADALECKI SUSAN, ELEFTERIOU FLORENT, ZHAO MING, Cytokines and Bone Remodeling, in Osteoporosis, 2008. Crossref
-
Fu Chao, Xu Dong, Wang Chang-Yuan, Jin Yue, Liu Qi, Meng Qiang, Liu Ke-Xin, Sun Hui-Jun, Liu Mo-Zhen, Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2 O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats, Journal of Cellular Physiology, 230, 9, 2015. Crossref
-
von Wilmowsky Cornelius, Bauer Sebastian, Roedl Stefanie, Neukam Friedrich Wilhelm, Schmuki Patrik, Schlegel Karl Andreas, The diameter of anodic TiO2 nanotubes affects bone formation and correlates with the bone morphogenetic protein-2 expression in vivo, Clinical Oral Implants Research, 23, 3, 2012. Crossref
-
References, in Bones and Cartilage, 2005. Crossref
-
Fowler Martin J., Neff Michael S., Borghaei Ruth C., Pease Elizabeth A., Mochan Eugene, Thornton Ruth D., Induction of Bone Morphogenetic Protein-2 by Interleukin-1 in Human Fibroblasts, Biochemical and Biophysical Research Communications, 248, 3, 1998. Crossref
-
Canalis Ernesto, Parker Kristen, Zanotti Stefano, Gremlin1 is required for skeletal development and postnatal skeletal homeostasis, Journal of Cellular Physiology, 227, 1, 2012. Crossref
-
Takayama Tadahiro, Suzuki Naoto, Narukawa Masataka, Tokunaga Tsuyoshi, Otsuka Kichibee, Ito Koichi, Enamel Matrix Derivative Stimulates Core Binding Factor α1/Runt-Related Transcription Factor-2 Expression via Activation of Smad1 in C2C12 Cells, Journal of Periodontology, 76, 2, 2005. Crossref
-
Park Seung-Won, Goo Tae-Won, Kim Seong Ryul, Choi Kwang-Ho, Recombinant human BMP-2/-7 heterodimer protein expression for bone tissue engineering using recombinant baculovirus expression system, International Journal of Industrial Entomology, 32, 2, 2016. Crossref
-
Yang Di, Okamura Hirohiko, Nakashima Yoshiki, Haneji Tatsuji, Histone Demethylase Jmjd3 Regulates Osteoblast Differentiation via Transcription Factors Runx2 and Osterix, Journal of Biological Chemistry, 288, 47, 2013. Crossref
-
Feng Jian Q, Chen Di, Ghosh-Choudhury Nandini, Esparza Javier, Mundy Gregory R, Harris Stephen E, Bone morphogenetic protein 2 transcripts in rapidly developing deer antler tissue contain an extended 5′ non-coding region arising from a distal promoter, Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1350, 1, 1997. Crossref
-
Lian Jane B., Stein Gary S., Osteoblast Biology, in Osteoporosis, 2001. Crossref
-
Ilmer Matthias, Karow Marisa, Geissler Claudia, Jochum Marianne, Neth Peter, Human Osteoblast–Derived Factors Induce Early Osteogenic Markers in Human Mesenchymal Stem Cells, Tissue Engineering Part A, 15, 9, 2009. Crossref
-
O??Connor J. Patrick, Animal Models of Heterotopic Ossification, Clinical Orthopaedics and Related Research, 346, 1998. Crossref
-
Marie P. J., Bone Morphogenetic Proteins: Role, Modes of Action and Potential Significance in Osteoporosis, in Novel Approaches to Treatment of Osteoporosis, 1998. Crossref
-
Guise Theresa A., Mundy Gregory R., Cancer and Bone*, Endocrine Reviews, 19, 1, 1998. Crossref
-
Smerdel-Ramoya Anna, Zanotti Stefano, Stadmeyer Lisa, Durant Deena, Canalis Ernesto, Skeletal Overexpression of Connective Tissue Growth Factor Impairs Bone Formation and Causes Osteopenia, Endocrinology, 149, 9, 2008. Crossref
-
Canalis Ernesto, Economides Aris N., Gazzerro Elisabetta, Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton, Endocrine Reviews, 24, 2, 2003. Crossref
-
Canalis Ernesto, Skeletal growth factors, in Marcus and Feldman's Osteoporosis, 2021. Crossref
-
Canalis Ernesto, Brunet Lisa J., Parker Kristen, Zanotti Stefano, Conditional Inactivation of Noggin in the Postnatal Skeleton Causes Osteopenia, Endocrinology, 153, 4, 2012. Crossref
-
Mandal Chandi C., Ganapathy Suthakar, Gorin Yves, Mahadev Kalyankar, Block Karen, Abboud Hanna E., Harris Stephen E., Ghosh-Choudhury Goutam, Ghosh-Choudhury Nandini, Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation, Biochemical Journal, 433, 2, 2011. Crossref
-
Mundy Gregory R., Directions of Drug Discovery in Osteoporosis, Annual Review of Medicine, 53, 1, 2002. Crossref
-
Shi Weibin, Chang Chenbei, Nie Shuyi, Xie Shutao, Wan Mei, Cao Xu, Endofin acts as a Smad anchor for receptor activation in BMP signaling, Journal of Cell Science, 120, 7, 2007. Crossref
-
Wan Huajing, Luo Fengming, Wert Susan E., Zhang Liqian, Xu Yan, Ikegami Machiko, Maeda Yutaka, Bell Sheila M., Whitsett Jeffrey A., Kruppel-like factor 5 is required for perinatal lung morphogenesis and function, Development, 135, 15, 2008. Crossref
-
Ghosh-Choudhury Nandini, Abboud Sherry L., Mahimainathan Lenin, Chandrasekar Bysani, Choudhury Goutam Ghosh, Phosphatidylinositol 3-Kinase Regulates Bone Morphogenetic Protein-2 (BMP-2)-induced Myocyte Enhancer Factor 2A-dependent Transcription of BMP-2 Gene in Cardiomyocyte Precursor Cells, Journal of Biological Chemistry, 278, 24, 2003. Crossref
-
Rydziel Sheila, Stadmeyer Lisa, Zanotti Stefano, Durant Deena, Smerdel-Ramoya Anna, Canalis Ernesto, Nephroblastoma Overexpressed (Nov) Inhibits Osteoblastogenesis and Causes Osteopenia, Journal of Biological Chemistry, 282, 27, 2007. Crossref
-
Shu Bing, Zhang Ming, Xie Rong, Wang Meina, Jin Hongting, Hou Wei, Tang Dezhi, Harris Stephen E., Mishina Yuji, O'Keefe Regis J., Hilton Matthew J., Wang Yongjun, Chen Di, BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development, Journal of Cell Science, 124, 20, 2011. Crossref
-
Tanikawa Rena, Tanikawa Takahisa, Hirashima Mitsuomi, Yamauchi Akira, Tanaka Yoshiya, Galectin-9 induces osteoblast differentiation through the CD44/Smad signaling pathway, Biochemical and Biophysical Research Communications, 394, 2, 2010. Crossref
-
Gazzerro Elisabetta, Smerdel-Ramoya Anna, Zanotti Stefano, Stadmeyer Lisa, Durant Deena, Economides Aris N., Canalis Ernesto, Conditional Deletion of Gremlin Causes a Transient Increase in Bone Formation and Bone Mass, Journal of Biological Chemistry, 282, 43, 2007. Crossref
-
Kode Aruna, Manavalan John S., Mosialou Ioanna, Bhagat Govind, Rathinam Chozha V., Luo Na, Khiabanian Hossein, Lee Albert, Murty Vundavalli V., Friedman Richard, Brum Andrea, Park David, Galili Naomi, Mukherjee Siddhartha, Teruya-Feldstein Julie, Raza Azra, Rabadan Raul, Berman Ellin, Kousteni Stavroula, Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts, Nature, 506, 7487, 2014. Crossref
-
Zhao Ming, Qiao Mei, Harris Stephen E., Chen Di, Oyajobi Babatunde O., Mundy Gregory R., The Zinc Finger Transcription Factor Gli2 Mediates Bone Morphogenetic Protein 2 Expression in Osteoblasts in Response to Hedgehog Signaling, Molecular and Cellular Biology, 26, 16, 2006. Crossref
-
Smerdel-Ramoya Anna, Zanotti Stefano, Deregowski Valerie, Canalis Ernesto, Connective Tissue Growth Factor Enhances Osteoblastogenesis in Vitro, Journal of Biological Chemistry, 283, 33, 2008. Crossref
-
Ghosh-Choudhury Nandini, Mandal Chandi C., Das Falguni, Ganapathy Suthakar, Ahuja Seema, Ghosh Choudhury Goutam, c-Abl-dependent Molecular Circuitry Involving Smad5 and Phosphatidylinositol 3-Kinase Regulates Bone Morphogenetic Protein-2-induced Osteogenesis, Journal of Biological Chemistry, 288, 34, 2013. Crossref
-
Bi Yanming, Stuelten Christina H., Kilts Tina, Wadhwa Sunil, Iozzo Renato V., Robey Pamela G., Chen Xiao-Dong, Young Marian F., Extracellular Matrix Proteoglycans Control the Fate of Bone Marrow Stromal Cells, Journal of Biological Chemistry, 280, 34, 2005. Crossref
-
Ghosh-Choudhury Nandini, Abboud Sherry L., Nishimura Riko, Celeste Anthony, Mahimainathan Lenin, Choudhury Goutam Ghosh, Requirement of BMP-2-induced Phosphatidylinositol 3-Kinase and Akt Serine/Threonine Kinase in Osteoblast Differentiation and Smad-dependent BMP-2 Gene Transcription, Journal of Biological Chemistry, 277, 36, 2002. Crossref
-
Deregowski Valerie, Gazzerro Elisabetta, Priest Leah, Rydziel Sheila, Canalis Ernesto, Notch 1 Overexpression Inhibits Osteoblastogenesis by Suppressing Wnt/β-Catenin but Not Bone Morphogenetic Protein Signaling, Journal of Biological Chemistry, 281, 10, 2006. Crossref
-
Liu Ying, Fu Dongjie, lncRNA ZNF710-AS1 Acts as a ceRNA for miR-146a-5p and miR-146b-5p to Accelerate Osteogenic Differentiation of PDLSCs by Upregulating the BMP6/Smad1/5/9 Pathway, Journal of Hard Tissue Biology, 31, 4, 2022. Crossref