每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
The Molecular and Cellular Biology of Pancreatic Cancer
摘要
Adenocarcinoma of the pancreas carries a grave prognosis for affected patients. Certain oncogenes (K-ras and HER-2/neu) are mutated in a large proportion of these aggressive tumors. Adenocarcinoma of the pancreas has also been associated with loss of tumor suppressor genes (p53, DPC4, pl6/MTS), either by deletion or by mutation and loss of function. Growth factors (EGF, TGF-α, HGF) and growth factor receptors (EGF-R, c-met, CCK) are expressed at levels not found in the normal pancreas. Finally, factors important for angiogenesis (FGF, integrins, selectins) are likely to play an important role in the growth and metastasis of clinically relevant tumors. This review attempts to summarize and assimilate current research into the molecular and cellular biology of pancreatic cancer.
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Takeda Ami, Osaki Mitsuhiko, Adachi Keiko, Honjo Soichiro, Ito Hisao, Role of the Phosphatidylinositol 3???-Kinase???Akt Signal Pathway in the Proliferation of Human Pancreatic Ductal Carcinoma Cell Lines, Pancreas, 28, 3, 2004. Crossref
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Aubert Muriel, Panicot-Dubois Laurence, Crotte Christian, Sbarra V�ronique, Lombardo Dominique, Sadoulet Marie-Odile, Mas Eric, Peritoneal colonization by human pancreatic cancer cells is inhibited by antisenseFUT3 sequence, International Journal of Cancer, 88, 4, 2000. Crossref
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Gopalakrishnan Velliyur K., Banerjee Abhijit G., Vishwanatha Jamboor K., Effect of FHIT gene replacement on growth, cell cycle and apoptosis in pancreatic cancer cells, Pancreatology, 3, 4, 2003. Crossref
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Bruns Christiane J., Harbison Matthew T., Kuniyasu Hiroki, Eue Ines, Fidler Isaiah J., In Vivo Selection and Characterization of Metastatic Variants from Human Pancreatic Adenocarcinoma by Using Orthotopic Implantation in Nude Mice, Neoplasia, 1, 1, 1999. Crossref
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Tepel J., Dagvadorj O., Kapischke M., Sipos B., Leins A., Kremer B., Kalthoff H., Significant growth inhibition of orthotopic pancreatic ductal adenocarcinoma by CpG oligonucleotides in immunodeficient mice, International Journal of Colorectal Disease, 21, 4, 2006. Crossref
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Han Haiyong, Zhao Yu, Cuthbertson Timothy, Hartman Rosemarie F., Rose Seth D., Cell Cycle Arrest and Apoptosis Induction by an Anticancer Chalcone Epoxide, Archiv der Pharmazie, 343, 8, 2010. Crossref
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Chow Jimmy Y. C., Carethers John M., Cho Chi H., Small interfering RNA technology in pancreatic ductal epithelial cells: future cancer therapy, Journal of Organ Dysfunction, 4, 4, 2008. Crossref
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Perugini Richard A., McDade Theodore P., Vittimberga Frank J., Callery Mark P., Pancreatic Cancer Cell Proliferation Is Phosphatidylinositol 3-Kinase Dependent, Journal of Surgical Research, 90, 1, 2000. Crossref
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Shah Shimul A., Potter Michael W., Ricciardi Rocco, Perugini Richard A., Callery Mark P., FRAP-p70s6K Signaling Is Required for Pancreatic Cancer Cell Proliferation, Journal of Surgical Research, 97, 2, 2001. Crossref
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McDade Theodore P., Perugini Richard A., Vittimberga Frank J., Callery Mark P., Ubiquitin-proteasome inhibition enhances apoptosis of human pancreatic cancer cells, Surgery, 126, 2, 1999. Crossref
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Vaquero Eva C, Edderkaoui Mouad, Nam Kyung J, Gukovsky Ilya, Pandol Stephen J, Gukovskaya Anna S, Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial and nonmitochondrial pathways, Gastroenterology, 125, 4, 2003. Crossref
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Tepel Jürgen, Kruse Marie-Luise, March Christina, Fiedler Alexander, Kapischke Matthias, Ketterer Thomas, Sipos Bence, Kremer Bernd, Kalthoff Holger, Terminally Modified Oligodeoxynucleotides Directed Against p53 in an Orthotopic Xenograft Model: A Novel Adjuvant Treatment Strategy for Pancreatic Ductal Carcinoma, Pancreas, 28, 1, 2004. Crossref
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McDade Theodore P., Perugini Richard A., Vittimberga Frank J., Carrigan Rebecca C., Callery Mark P., Salicylates Inhibit NF-κB Activation and Enhance TNF-α-Induced Apoptosis in Human Pancreatic Cancer Cells, Journal of Surgical Research, 83, 1, 1999. Crossref
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Chandler Nicole M, Canete Jonathan J, Callery Mark P, Increased expression of NF-κB subunits in human pancreatic cancer cells1,2, Journal of Surgical Research, 118, 1, 2004. Crossref
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Shah Shimul A., Potter Michael W., McDade Theodore P., Ricciardi Rocco, Perugini Richard A., Elliott Peter J., Adams Julian, Callery Mark P., 26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer, Journal of Cellular Biochemistry, 82, 1, 2001. Crossref
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Banerjee Sushanta K, Zoubine Mikhail N, Mullick Monalisa, Weston Allan P, Cherian Rachel, Campbell Donald R, Tumor Angiogenesis in Chronic Pancreatitis and Pancreatic Adenocarcinoma: Impact of K-ras Mutations, Pancreas, 20, 3, 2000. Crossref
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Yao Zan, Okabayashi Yoshinori, Yutsudo Yoshihiro, Kitamura Tadahiro, Ogawa Wataru, Kasuga Masato, Role of Akt in Growth and Survival of PANC-1 Pancreatic Cancer Cells, Pancreas, 24, 1, 2002. Crossref
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Feng J., Adsay N. V., Kruger M., Ellis K. L., Nagothu K., Majumdar A. P. N., Sarkar F. H., Expression of ERRP in Normal and Neoplastic Pancreata and Its Relationship to Clinicopathologic Parameters in Pancreatic Adenocarcinoma, Pancreas, 25, 4, 2002. Crossref
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Boland Genevieve M., Thayer Sarah P., Molecular Signaling Pathways in Pancreatic Cancer, in Pancreatic Cancer, 2008. Crossref
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Yee Nelson S., Toward the Goal of Personalized Therapy in Pancreatic Cancer by Targeting the Molecular Phenotype, in Impact of Genetic Targets on Cancer Therapy, 779, 2013. Crossref
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Jean Marina E., Lowy Andrew M., Chiao Paul J., Evans Douglas B., The Molecular Biology of Pancreatic Cancer, in Pancreatic Cancer, 2002. Crossref
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Detjen K M, Farwig K, Welzel M, Wiedenmann B, Rosewicz S, Interferon γ inhibits growth of human pancreatic carcinoma cells via caspase-1 dependent induction of apoptosis, Gut, 49, 2, 2001. Crossref
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Dammann Reinhard, Schagdarsurengin Undraga, Liu Limin, Otto Noreen, Gimm Oliver, Dralle Henning, Boehm Bernhard O, Pfeifer Gerd P, Hoang-Vu Cuong, Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma, Oncogene, 22, 24, 2003. Crossref
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Edderkaoui Mouad, Hong Peggy, Lee Jong K., Pandol Stephen J., Gukovskaya Anna S., Insulin-like Growth Factor-I Receptor Mediates the Prosurvival Effect of Fibronectin, Journal of Biological Chemistry, 282, 37, 2007. Crossref
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Su Zao-zhong, Lebedeva Irina V., Gopalkrishnan Rahul V., Goldstein Neil I., Stein C. A., Reed John C., Dent Paul, Fisher Paul B., A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells, Proceedings of the National Academy of Sciences, 98, 18, 2001. Crossref
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Gesierich Sabine, Paret Claudia, Hildebrand Dagmar, Weitz Jürgen, Zgraggen Kaspar, Schmitz-Winnenthal Friedrich H., Horejsi Vaclav, Yoshie Osamu, Herlyn Dorothee, Ashman Leonie K., Zöller Margot, Colocalization of the Tetraspanins, CO-029 and CD151, with Integrins in Human Pancreatic Adenocarcinoma: Impact on Cell Motility, Clinical Cancer Research, 11, 8, 2005. Crossref
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Sarkar Devanand, Su Zao-zhong, Vozhilla Nicolaq, Park Eun Sook, Randolph Aaron, Valerie Kristoffer, Fisher Paul B., Targeted Virus Replication Plus Immunotherapy Eradicates Primary and Distant Pancreatic Tumors in Nude Mice, Cancer Research, 65, 19, 2005. Crossref
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Furge Kyle A., Kiewlich David, Le Phuong, Vo My Nga, Faure Michel, Howlett Anthony R., Lipson Kenneth E., Woude George F. Vande, Webb Craig P., Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase, Proceedings of the National Academy of Sciences, 98, 19, 2001. Crossref
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Jin Hongkui, Yang Renhui, Zheng Zhong, Romero Mally, Ross Jed, Bou-Reslan Hani, Carano Richard A.D., Kasman Ian, Mai Elaine, Young Judy, Zha Jiping, Zhang Zemin, Ross Sarajane, Schwall Ralph, Colbern Gail, Merchant Mark, MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival, Cancer Research, 68, 11, 2008. Crossref