每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
PTHrP Gene Expression in Cancer: Do All Paths Lead to Ets?
摘要
Parathyroid hormone-related protein (PTHrP) came to the attention of the scientific community in the mid-1980s because of its association with the paraneoplastic syndrome of humoral hypercalcemia of malignancy. Recently, a crucial role for the peptide has been identified in the metastatic growth of cancer cells in bone. Efforts to understand the peptide's role in these pathological processes have evolved into the study of PTHrP gene expression. Currently, regulation of the third PTHrP promoter is beginning to be understood in the context of activation of certain signaling pathways involved in the growth and progression of specific neoplasms. In addition, factors that modulate the entire PTHrP-transcriptional unit, as well as the stability of the mRNA, are being elucidated at the level of cis-acting sequences.
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Gilmore Jennifer L., Scott Jeffrey A., Bouizar Zhor, Robling Alex, Pitfield Sarah E., Riese David J., Foley John, Amphiregulin-EGFR signaling regulates PTHrP gene expression in breast cancer cells, Breast Cancer Research and Treatment, 110, 3, 2008. Crossref
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Foley John, Nickerson Nicole K., Nam Seungyoon, Allen Kah Tan, Gilmore Jennifer L., Nephew Kenneth P., Riese David J., EGFR signaling in breast cancer: Bad to the bone, Seminars in Cell & Developmental Biology, 21, 9, 2010. Crossref
-
Shu Sherry T., Martin Chelsea K., Thudi Nanda K., Dirksen Wessel P., Rosol Thomas J., Osteolytic bone resorption in adult T-cell leukemia/lymphoma, Leukemia & Lymphoma, 51, 4, 2010. Crossref
-
Gutierrez-Hartmann Arthur, Duval Dawn L., Bradford Andrew P., ETS transcription factors in endocrine systems, Trends in Endocrinology & Metabolism, 18, 4, 2007. Crossref
-
Foley John, Nickerson Nicole, Riese David J., Hollenhorst Peter C., Lorch Gwendolen, Foley Anne M., At the crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of bone, Odontology, 100, 2, 2012. Crossref
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Yao Masahiro, Murakami Takayuki, Shioi Koichi, Mizuno Nobuhiko, Ito Hiroki, Kondo Keiichi, Hasumi Hisashi, Sano Futoshi, Makiyama Kazuhide, Nakaigawa Noboru, Kishida Takeshi, Nagashima Yoji, Yamanaka Shoji, Kubota Yoshinobu, Tumor signatures ofPTHLHoverexpression, high serum calcium, and poor prognosis were observed exclusively in clear cell but not non clear cell renal carcinomas, Cancer Medicine, 3, 4, 2014. Crossref
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Dittmer Angela, Vetter Martina, Schunke Dario, Span Paul N., Sweep Fred, Thomssen Christoph, Dittmer Jürgen, Parathyroid Hormone-related Protein Regulates Tumor-relevant Genes in Breast Cancer Cells, Journal of Biological Chemistry, 281, 21, 2006. Crossref
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Hernandez Laura L., Gregerson Karen A., Horseman Nelson D., Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals, American Journal of Physiology-Endocrinology and Metabolism, 302, 8, 2012. Crossref
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McCarty Mark F., Block Keith I., Toward a Core Nutraceutical Program for Cancer Management, Integrative Cancer Therapies, 5, 2, 2006. Crossref
-
Ibrahim Toni, Farolfi Alberto, Mercatali Laura, Ricci Marianna, Amadori Dino, Metastatic Bone Disease in the Era of Bone-Targeted Therapy: Clinical Impact, Tumori Journal, 99, 1, 2013. Crossref
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Mrazek Amy A., Bhatia Vandanajay, Falzon Miriam, Spratt Heidi, Chao Celia, Hellmich Mark R., Apigenin Decreases Acinar Cell Damage in Pancreatitis, Pancreas, 48, 5, 2019. Crossref
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Ranelletti Franco Oreste, Monego Giovanni, Parathyroid Hormone–Related Peptide Signaling in Cancer, in Cell Signaling & Molecular Targets in Cancer, 2012. Crossref
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Chakravarti Bandana, Dwivedi Shailendra K. Dhar, Mithal Ambrish, Chattopadhyay Naibedya, Biochemistry, Physiology, and Pathophysiology of Parathyroid Hormone-Related Peptide, in Diseases of the Parathyroid Glands, 2012. Crossref
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Abe Masatoshi, Horiuchi Noboru, Dexamethasone Suppresses Parathyroid Hormone-related Protein Expression by Human Oral Squamous Carcinoma Cells (HSC-3), Journal of Oral Biosciences, 52, 1, 2010. Crossref
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Petrillo Angelica, Giunta Emilio Francesco, Pappalardo Annalisa, Bosso Davide, Attademo Laura, Cardalesi Cinzia, Diana Anna, Fabbrocini Antonietta, Fabozzi Teresa, Giordano Pasqualina, Ottaviano Margaret, Rosanova Mario, Silvestri Antonia, Federico Piera, Daniele Bruno, Bone Metastases from Gastric Cancer: What We Know and How to Deal with Them, Journal of Clinical Medicine, 10, 8, 2021. Crossref
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Nadella Murali VP, Shu Sherry T, Dirksen Wessel P, Thudi Nanda K, Nadella Kiran S, Fernandez Soledad A, Lairmore Michael D, Green Patrick L, Rosol Thomas J, Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: Implications for transformation, Retrovirology, 5, 1, 2008. Crossref
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Euhus David, Bu Dawei, Xie Xian-Jin, Sarode Venetia, Ashfaq Raheela, Hunt Kelly, Xia Weiya, O'Shaughnessy Joyce, Grant Michael, Arun Banu, Dooley William, Miller Alexander, Flockhart David, Lewis Cheryl, Tamoxifen Downregulates Ets Oncogene Family Members ETV4 and ETV5 in Benign Breast Tissue: Implications for Durable Risk Reduction, Cancer Prevention Research, 4, 11, 2011. Crossref
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Onyema Michael C., Drakou Eftychia E., Dimitriadis Georgios K., Endocrine abnormality in paraneoplastic syndrome, Best Practice & Research Clinical Endocrinology & Metabolism, 36, 3, 2022. Crossref
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Pitarresi Jason R., Norgard Robert J., Chiarella Anna M., Suzuki Kensuke, Bakir Basil, Sahu Varun, Li Jinyang, Zhao Jun, Marchand Benoît, Wengyn Maximilian D., Hsieh Antony, Kim Il-Kyu, Zhang Amy, Sellin Karine, Lee Vivian, Takano Shigetsugu, Miyahara Yoji, Ohtsuka Masayuki, Maitra Anirban, Notta Faiyaz, Kremer Richard, Stanger Ben Z., Rustgi Anil K., PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability, Cancer Discovery, 11, 7, 2021. Crossref
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Gilmore Jennifer L., Gonterman Ryan M., Menon Keshav, Lorch Gwendolen, Riese David J., Robling Alex, Foley John, Reconstitution of Amphiregulin–Epidermal Growth Factor Receptor Signaling in Lung Squamous Cell Carcinomas Activates PTHrP Gene Expression and Contributes to Cancer-Mediated Diseases of the Bone, Molecular Cancer Research, 7, 10, 2009. Crossref