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真核基因表达评论综述™
影响因子: 1.841 5年影响因子: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukaryotGeneExpr.2019025774
pages 1-18

Wnt Network: A Brief Review of Pathways and Multifunctional Components

Fereshte Abdolmaleki
Student Research Committee, Qazvin University of Medical Sciences, School of Medicine, Qazvin, Iran
Hossein Ahmadpour-Yazdi
Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran; Medical Biotechnology Department, Faculty of Paramedical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran
Seyed Mohammad Gheibi Hayat
Department of Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Nematollah Gheibi
Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
Thomas P. Johnston
Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri, USA
Amirhossein Sahebkar
Halal Research Center of IRI, FDA, Tehran, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

ABSTRACT

The Wnt signaling pathway appears to activate intracellular signaling transduction in embryonic development, cell migration, hematopoiesis, and several diseases. Wnt signaling is basically recognized as a canonical β-catenin-dependent signaling pathway. However, in recent years, generally three Wnt-mediated pathways have been investigated, which operate independently of β-catenin and include calcium/calmodulin-dependent kinase II and protein kinase C, planar cell polarity, and a third one recruits hetrotrimeric GTP-binding proteins to stimulate phospholipase C and phosphodiesterase. We provide an overview of the noncanonical Wnt signaling pathway and then will focus on canonical Wnt signaling components, Wnt ligands, agonists, and antagonist. This review will also discuss β-catenin, both cytoplasmic and nuclear mechanisms, through signaling transduction, and, as a consequence, we have briefly highlighted potential implications of Wnt/β-catenin in some cancers.

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