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真核基因表达评论综述™
影响因子: 1.841 5年影响因子: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukaryotGeneExpr.2017019532
pages 321-329

Sirtuins in Brain Aging and Neurological Disorders

Muhammad Imran Qadir
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Bosan Road, Multan, Pakistan
Sidra Anwar
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan

ABSTRACT

The many ways of aging have been and continue to be investigated. For this reason, over many years, several studies have resolved some of the genetic details underlying aging processes. It resulted in the identification of a yeast gene known as Sir2, which is a longevity modulator. Sir2 and SIRT1 are the mammalian homologs of yeast genes. Sirtuins (including SIRT1) play an important role in aging of the brain and the metabolic regulation pathway in mammals. Aging in the brain is caused by the loss of neurophysiologic functions due to neurodegeneration. The sirtuin family plays a central role in the beneficial effects of calorie restriction (CR). CR is linked with an increase in life span and decrease in the risk of diseases related to the brain. Sirtuins may be helpful for us in studying the process of aging and treatment of diseases related with aging.