每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
Proteolytic Cleavage of Molecules Involved in Cell Death or Survival Pathways: A Role in the Control of Apoptosis?
摘要
Proteolytic modification of certain key regulatory molecules involved in apoptotic and prosurvival pathways may be a feature of the control of programmed cell death. Four molecules of the Bcl-2 family (BID, Bcl-2, Bax, Bcl-XL) have been reported to be cleaved during apoptosis, as has a cellular inhibitor of apoptosis (XIAP). Two proteins involved in NF-kB activation, RIP and TRAF1, are cleaved during apoptosis induced by agents that activate both pathways. MEKK1, a molecule involved in a protein kinase stress signaling cascade that contributes to apoptosis and NF-kB activation, also undergoes cleavage. In each case, the cleavage products may result in the inactivation of a former function or the gaining of a new function, thus contributing to the delicately balanced regulation of apoptosis.
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