每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
Transcriptional Augmentation: Modulation of Gene Expression by Scaffold/Matrix-Attached Regions (S/MAR Elements)
摘要
For a long time S/MARs could only be characterized by the assays in vitro that led to their detection. Only recently a number of biological activities emerged that are common to most or all S/MARs that are detected by the classic procedures. This review focuses on the phenomenon of transcriptional augmentation that is found for genomically anchored or episomal genes and on a group of partially overlapping activities that are suited to maintain an episomal status. Further, it is attempted to correlate properties of the S/MAR-scaffold interaction with prominent or prototype protein binding partners.
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Festa Margherita, Brun Paola, Piccinini Renata, Castagliuolo Ignazio, Basso Barbara, Zecconi Alfonso, Staphylococcus aureus Efb protein expression in Nicotiana tabacum and immune response to oral administration, Research in Veterinary Science, 94, 3, 2013. Crossref
-
Chen Huai-Ju, Wang Shu-Jen, Chen Chien-Cheng, Yeh Kai-Wun, New gene construction strategy in T-DNA vector to enhance expression level of sweet potato sporamin and insect resistance in transgenic Brassica oleracea, Plant Science, 171, 3, 2006. Crossref
-
Girod Pierre-Alain, Mermod Nicolas, Use of scaffold/matrix-attachment regions for protein production, in Gene Transfer and Expression in Mammalian Cells, 38, 2003. Crossref
-
Bode J., Benham C., Ernst E., Knopp A., Marschalek R., Strick R., Strissel P., Fatal connections: When DNA ends meet on the nuclear matrix, Journal of Cellular Biochemistry, 79, S35, 2000. Crossref
-
Garland J., Energy management – a critical role in cancer induction?, Critical Reviews in Oncology/Hematology, 88, 1, 2013. Crossref
-
Burkov I. A., Serova I. A., Battulin N. R., Smirnov A. V., Babkin I. V., Andreeva L. E., Dvoryanchikov G. A., Serov O. L., Expression of the human granulocyte–macrophage colony stimulating factor (hGM-CSF) gene under control of the 5′-regulatory sequence of the goat alpha-S1-casein gene with and without a MAR element in transgenic mice, Transgenic Research, 22, 5, 2013. Crossref
-
Schambach Axel, Moritz Thomas, Toward Position-independent Retroviral Vector Expression in Pluripotent Stem Cells, Molecular Therapy, 21, 8, 2013. Crossref
-
Koirala Adarsha, Conley Shannon M., Naash Muna I., A review of therapeutic prospects of non-viral gene therapy in the retinal pigment epithelium, Biomaterials, 34, 29, 2013. Crossref
-
Girod Pierre-Alain, Nguyen Duc-Quang, Calabrese David, Puttini Stefania, Grandjean Mélanie, Martinet Danielle, Regamey Alexandre, Saugy Damien, Beckmann Jacques S, Bucher Philipp, Mermod Nicolas, Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cells, Nature Methods, 4, 9, 2007. Crossref
-
Hernandez-Hernandez J. M., Mallappa C., Nasipak B. T., Oesterreich S., Imbalzano A. N., The Scaffold attachment factor b1 (Safb1) regulates myogenic differentiation by facilitating the transition of myogenic gene chromatin from a repressed to an activated state, Nucleic Acids Research, 41, 11, 2013. Crossref
-
Koirala Adarsha, Makkia Rasha S., Conley Shannon M., Cooper Mark J., Naash Muna I., S/MAR-containing DNA nanoparticles promote persistent RPE gene expression and improvement in RPE65-associated LCA, Human Molecular Genetics, 22, 8, 2013. Crossref
-
Liu Q Y, Ribecco-Lutkiewicz M, Carson C, Testolin L, Bergeron D, Kohwi-Shigematsu T, Walker P R, Sikorska M, Mapping the initial DNA breaks in apoptotic Jurkat cells using ligation-mediated PCR, Cell Death & Differentiation, 10, 3, 2003. Crossref
-
Yu Junying, Episomal Vectors, in Primary and Stem Cells, 2011. Crossref
-
Giannakopoulos Aristeidis, Stavrou Eleana F., Zarkadis Ioannis, Zoumbos Nicholas, Thrasher Adrian J., Athanassiadou Aglaia, The Functional Role of S/MARs in Episomal Vectors as Defined by the Stress-Induced Destabilization Profile of the Vector Sequences, Journal of Molecular Biology, 387, 5, 2009. Crossref
-
Butaye Katleen M.J., Cammue Bruno P.A., Delauré Stijn L., De Bolle Miguel F.C., Approaches to Minimize Variation of Transgene Expression in Plants, Molecular Breeding, 16, 1, 2005. Crossref
-
Nehlsen K., Herrmann S., Zauers J., Hauser H., Wirth D., Toxin–antitoxin based transgene expression in mammalian cells, Nucleic Acids Research, 38, 5, 2010. Crossref
-
Luis Galbete José, Buceta Montserrat, Mermod Nicolas, MAR elements regulate the probability of epigenetic switching between active and inactive gene expression, Mol. BioSyst., 5, 2, 2009. Crossref
-
Garee Jason P., Oesterreich Steffi, SAFB1's multiple functions in biological control-lots still to be done!, Journal of Cellular Biochemistry, 109, 2, 2010. Crossref
-
Cai Rong, Xu Weirong, Dai Bingbing, Cai Xia, Xu Rongting, Lu Jian, SATB1 binds an intronic MAR sequence in human PI3kγ in vitro, Molecular Biology Reports, 37, 3, 2010. Crossref
-
Moreno Rafael, Martínez Itziar, Petriz Jordi, Nadal Marga, Tintoré Xavier, Gonzalez Juan Ramón, Gratacós Eduard, Aran Josep M., The β-Interferon Scaffold Attachment Region Confers High-Level Transgene Expression and Avoids Extinction by Epigenetic Modifications of Integrated Provirus in Adipose Tissue-Derived Human Mesenchymal Stem Cells, Tissue Engineering Part C: Methods, 17, 3, 2011. Crossref
-
Butaye Katleen M.J., Goderis Inge J.W.M., Wouters Piet F.J., Pues Jonathan M.-T.G., Delauré Stijn L., Broekaert Willem F., Depicker Ann, Cammue Bruno P.A., De Bolle Miguel F.C., Stable high-level transgene expression inArabidopsis thalianausing gene silencing mutants and matrix attachment regions, The Plant Journal, 39, 3, 2004. Crossref
-
Wong Suet Ping, Argyros Orestis, Harbottle Richard P., Sustained Expression from DNA Vectors, in Nonviral Vectors for Gene Therapy - Physical Methods and Medical Translation, 89, 2015. Crossref
-
Shiue Chiou-Nan, Nematollahi-Mahani Amir, Wright Anthony P.H., Myc-induced anchorage of the rDNA IGS region to nucleolar matrix modulates growth-stimulated changes in higher-order rDNA architecture, Nucleic Acids Research, 42, 9, 2014. Crossref
-
Dobreva Gergana, Chahrour Maria, Dautzenberg Marcel, Chirivella Laura, Kanzler Benoit, Fariñas Isabel, Karsenty Gerard, Grosschedl Rudolf, SATB2 Is a Multifunctional Determinant of Craniofacial Patterning and Osteoblast Differentiation, Cell, 125, 5, 2006. Crossref
-
Spencer Shawal, Gugliotta Agustina, Koenitzer Jennifer, Hauser Hansjörg, Wirth Dagmar, Stability of single copy transgene expression in CHOK1 cells is affected by histone modifications but not by DNA methylation, Journal of Biotechnology, 195, 2015. Crossref
-
Abranches Rita, Shultz Randall W., Thompson William F., Allen George C., Matrix attachment regions and regulated transcription increase and stabilize transgene expression, Plant Biotechnology Journal, 3, 5, 2005. Crossref
-
Lufino Michele MP, Edser Pauline AH, Wade-Martins Richard, Advances in High-capacity Extrachromosomal Vector Technology: Episomal Maintenance, Vector Delivery, and Transgene Expression, Molecular Therapy, 16, 9, 2008. Crossref
-
Chang Alex H, Sadelain Michel, The Genetic Engineering of Hematopoietic Stem Cells: the Rise of Lentiviral Vectors, the Conundrum of the LTR, and the Promise of Lineage-restricted Vectors, Molecular Therapy, 15, 3, 2007. Crossref
-
Yang Hongmei, Ma Gang, Lin Charles H., Orr Melissa, Wathelet Marc G., Mechanism for transcriptional synergy between interferon regulatory factor (IRF)-3 and IRF-7 in activation of the interferon-β gene promoter, European Journal of Biochemistry, 271, 18, 2004. Crossref
-
Kim Jeong Do, Yoon Yeup, Hwang Hye-Yeon, Park Jeong Soo, Yu Sungryul, Lee Jina, Baek Kwanghee, Yoon Jaeseung, Efficient Selection of Stable Chinese Hamster Ovary (CHO) Cell Lines for Expression of Recombinant Proteins by Using Human Interferon β SAR Element, Biotechnology Progress, 21, 3, 2008. Crossref
-
Foster Helen A., Bridger Joanna M., The genome and the nucleus: a marriage made by evolution, Chromosoma, 114, 4, 2005. Crossref
-
Linnemann Amelia K., Platts Adrian E., Krawetz Stephen A., Differential nuclear scaffold/matrix attachment marks expressed genes†, Human Molecular Genetics, 18, 4, 2009. Crossref
-
Lee Jialing, Lau Joanne, Chong Grace, Chao Sheng-Hao, Cell-specific effects of human cytomegalovirus unique region on recombinant protein expression, Biotechnology Letters, 29, 12, 2007. Crossref
-
Li Hui Joyce, Haque Zaffar K., Chen Amy, Mendelsohn Michael, RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix, Journal of Cellular Biochemistry, 102, 4, 2007. Crossref
-
Turan Soeren, Qiao Junhua, Madden Sally, Benham Craig, Kotz Marina, Schambach Axel, Bode Juergen, Expanding Flp-RMCE options: the potential of Recombinase Mediated Twin-Site Targeting (RMTT), Gene, 546, 2, 2014. Crossref
-
Haran Tali E., Mohanty Udayan, The unique structure of A-tracts and intrinsic DNA bending, Quarterly Reviews of Biophysics, 42, 1, 2009. Crossref
-
Makarevitch Irina, Somers David A., Association of Arabidopsis topoisomerase IIA cleavage sites with functional genomic elements and T-DNA loci, The Plant Journal, 48, 5, 2006. Crossref
-
Ehrhardt Anja, Peng Peter D., Xu Hui, Meuse Leonard, Kay Mark A., Optimization of Cis-Acting Elements for Gene Expression from Nonviral VectorsIn Vivo, Human Gene Therapy, 14, 3, 2003. Crossref
-
Francis Kirk E., Spiker Steven, Identification of Arabidopsis thaliana transformants without selection reveals a high occurrence of silenced T-DNA integrations, The Plant Journal, 41, 3, 2004. Crossref
-
Harraghy Niamh, Regamey Alexandre, Girod Pierre-Alain, Mermod Nicolas, Identification of a potent MAR element from the mouse genome and assessment of its activity in stable and transient transfections, Journal of Biotechnology, 154, 1, 2011. Crossref
-
Grandjean Mélanie, Girod Pierre-Alain, Calabrese David, Kostyrko Kaja, Wicht Marianne, Yerly Florence, Mazza Christian, Beckmann Jacques S., Martinet Danielle, Mermod Nicolas, High-level transgene expression by homologous recombination-mediated gene transfer, Nucleic Acids Research, 39, 15, 2011. Crossref
-
Betts Zeynep, Dickson Alan J., Assessment of UCOE on Recombinant EPO Production and Expression Stability in Amplified Chinese Hamster Ovary Cells, Molecular Biotechnology, 57, 9, 2015. Crossref
-
Argyros Orestis, Wong Suet Ping, Fedonidis Constantinos, Tolmachov Oleg, Waddington Simon N., Howe Steven J., Niceta Marcello, Coutelle Charles, Harbottle Richard P., Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver, Journal of Molecular Medicine, 89, 5, 2011. Crossref
-
Hagedorn Claudia, Wong Suet-Ping, Harbottle Richard, Lipps Hans J., Scaffold/Matrix Attached Region-Based Nonviral Episomal Vectors, Human Gene Therapy, 22, 8, 2011. Crossref
-
Vidaković Melita, Gluch Angela, Qiao Junhua, Oumard Andrè, Frisch Matthias, Poznanović Goran, Bode Juergen, PARP-1 Expression in the Mouse is Controlled by an Autoregulatory Loop: PARP-1 Binding to an Upstream S/MAR Element and to a Novel Recognition Motif in its Promoter Suppresses Transcription, Journal of Molecular Biology, 388, 4, 2009. Crossref
-
Martins Rui Pires, Ujfalusi Aniko A., Csiszar Katalin, Krawetz Stephen A., Characterization of the Region Encompassing the Human Lysyl Oxidase Locus, DNA Sequence, 12, 4, 2001. Crossref
-
Argyros Orestis, Wong Suet-Ping, Harbottle Richard P, Non-viral episomal modification of cells using S/MAR elements, Expert Opinion on Biological Therapy, 11, 9, 2011. Crossref
-
Mendu Nandini, Massel Mara, Spiker Steven, Increasing loop domain size does not diminish effects of matrix attachment regions on transgene expression in tobacco cells in culture, FEBS Letters, 496, 1, 2001. Crossref
-
Jiménez-Bremont Juan Francisco, Ruiz-Herrera José, Analysis of the transcriptional regulation of YlODC gene from the dimorphic fungus Yarrowia lipolytica, Microbiological Research, 163, 6, 2008. Crossref
-
Qiao Junhua, Oumard André, Wegloehner Wolfgang, Bode Juergen, Novel Tag-and-Exchange (RMCE) Strategies Generate Master Cell Clones with Predictable and Stable Transgene Expression Properties, Journal of Molecular Biology, 390, 4, 2009. Crossref
-
Glazko Galina V., Koonin Eugene V., Rogozin Igor B., Shabalina Svetlana A., A significant fraction of conserved noncoding DNA in human and mouse consists of predicted matrix attachment regions, Trends in Genetics, 19, 3, 2003. Crossref
-
Harraghy Niamh, Calabrese David, Fisch Igor, Girod Pierre-Alain, LeFourn Valérie, Regamey Alexandre, Mermod Nicolas, Epigenetic regulatory elements: Recent advances in understanding their mode of action and use for recombinant protein production in mammalian cells, Biotechnology Journal, 10, 7, 2015. Crossref
-
Bode Jürgen, Winkelmann Silke, Götze Sandra, Spiker Steven, Tsutsui Ken, Bi Chengpeng, A.K. Prashanth, Benham Craig, Correlations between Scaffold/Matrix Attachment Region (S/MAR) Binding Activity and DNA Duplex Destabilization Energy, Journal of Molecular Biology, 358, 2, 2006. Crossref
-
Hikichi Yukiko, Yamaoka Masuo, Kusaka Masami, Hara Takahito, Selective androgen receptor modulator activity of a steroidal antiandrogen TSAA-291 and its cofactor recruitment profile, European Journal of Pharmacology, 765, 2015. Crossref
-
Drennan K.J., Linnemann A.K., Platts A.E., Heng H.H., Armant D.R., Krawetz S.A., Nuclear Matrix Association: Switching to the Invasive Cytotrophoblast, Placenta, 31, 5, 2010. Crossref
-
Sgourou Argyro, Routledge Samantha, Spathas Dionysios, Athanassiadou Aglaia, Antoniou Michael N., Physiological levels of HBB transgene expression from S/MAR element-based replicating episomal vectors, Journal of Biotechnology, 143, 2, 2009. Crossref
-
Hsu Charlie Yu Ming, Uludağ Hasan, Nucleic-acid based gene therapeutics: delivery challenges and modular design of nonviral gene carriers and expression cassettes to overcome intracellular barriers for sustained targeted expression, Journal of Drug Targeting, 20, 4, 2012. Crossref
-
Dai Bingbing, Ying Lei, Cai Rong, Li Ying, Zhang Xingqian, Lu Jian, Qian Guanxiang, Identification of a nuclear matrix attachment region like sequence in the last intron of PI3Kγ, Biochemical and Biophysical Research Communications, 341, 2, 2006. Crossref
-
Zhou Cong-Zhao, Confalonieri Fabrice, Esnault Catherine, Zivanovic Yvan, Jacquet Michel, Janin Joel, Perasso Roland, Li Zhen-Gang, Duguet Michel, The 62-kb upstream region of Bombyx mori fibroin heavy chain gene is clustered of repetitive elements and candidate matrix association regions, Gene, 312, 2003. Crossref
-
Jeanson Laurence, Subra Frédéric, Vaganay Sabine, Hervy Martial, Marangoni Elizabeth, Bourhis Jean, Mouscadet Jean-François, Effect of Ku80 Depletion on the Preintegrative Steps of HIV-1 Replication in Human Cells, Virology, 300, 1, 2002. Crossref
-
Lee Jialing, Klase Zachary, Gao Xiaoqi, Caldwell Jeremy S., Stinski Mark F., Kashanchi Fatah, Chao Sheng-Hao, Cellular homeoproteins, SATB1 and CDP, bind to the unique region between the human cytomegalovirus UL127 and major immediate-early genes, Virology, 366, 1, 2007. Crossref
-
St-Arnaud René, Hekmatnejad Bahareh, Combinatorial control of ATF4-dependent gene transcription in osteoblasts, Annals of the New York Academy of Sciences, 1237, 1, 2011. Crossref
-
Conley Shannon M., Naash Muna I., Nanoparticles for retinal gene therapy, Progress in Retinal and Eye Research, 29, 5, 2010. Crossref
-
Chavali Pavithra Lakshminarasimhan, Funa Keiko, Chavali Sreenivas, Cis -regulation of microRNA expression by scaffold/matrix-attachment regions, Nucleic Acids Research, 39, 16, 2011. Crossref
-
Zahn-Zabal Monique, Kobr Michel, Girod Pierre-Alain, Imhof Markus, Chatellard Philippe, de Jesus Maria, Wurm Florian, Mermod Nicolas, Development of stable cell lines for production or regulated expression using matrix attachment regions, Journal of Biotechnology, 87, 1, 2001. Crossref
-
Cacciatore Jonathan J., Chasin Lawrence A., Leonard Edward F., Gene amplification and vector engineering to achieve rapid and high-level therapeutic protein production using the Dhfr-based CHO cell selection system, Biotechnology Advances, 28, 6, 2010. Crossref
-
Choi Kwang-Hwan, Park Jin-Kyu, Kim Hye-Sun, Uh Kyung-Jun, Son Dong-Chan, Lee Chang-Kyu, Pant Aditya Bhushan, Epigenetic Changes of Lentiviral Transgenes in Porcine Stem Cells Derived from Embryonic Origin, PLoS ONE, 8, 8, 2013. Crossref
-
Pérez-González Ana, Caro Elena, Hindrances to the Efficient and Stable Expression of Transgenes in Plant Synthetic Biology Approaches, in Systems Biology Application in Synthetic Biology, 2016. Crossref
-
HU Xiaoming, GUO Jing, BAI Chunling, WEI Zhuying, GAO Li, HU Tingmao, BOU Shorgan, LI Guangpeng, Matrix attachment regions included in a bicistronic vector enhances and stabilizes follistatin gene expressions in both transgenic cells and transgenic mice, Frontiers of Agricultural Science and Engineering, 3, 1, 2016. Crossref
-
Jackson Dean A., Juranek Stefan, Lipps Hans J., Designing Nonviral Vectors for Efficient Gene Transfer and Long-Term Gene Expression, Molecular Therapy, 14, 5, 2006. Crossref
-
Arope Salina, Harraghy Niamh, Pjanic Milos, Mermod Nicolas, Zhang Chi, Molecular Characterization of a Human Matrix Attachment Region Epigenetic Regulator, PLoS ONE, 8, 11, 2013. Crossref
-
Sun Qiu-li, Zhao Chun-peng, Chen Shao-nan, Wang Li, Wang Tian-yun, Molecular characterization of a human matrix attachment region that improves transgene expression in CHO cells, Gene, 582, 2, 2016. Crossref
-
Wilson Rosemary H. C., Coverley Dawn, Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos, Scientific Reports, 7, 1, 2017. Crossref
-
Araki Yoshio, Hamafuji Tetsuro, Noguchi Chiemi, Shimizu Noriaki, Lin Baochuan, Efficient Recombinant Production in Mammalian Cells Using a Novel IR/MAR Gene Amplification Method, PLoS ONE, 7, 7, 2012. Crossref
-
Li Qin, Wang Wen, Guo Xiao, Jia Yan-Long, Wang Yan-Fang, Wang Tian-Yun, A short synthetic chimeric sequence harboring matrix attachment region/PSAR2 increases transgene expression in Chinese hamster ovary cells, Bioscience, Biotechnology, and Biochemistry, 81, 9, 2017. Crossref
-
Thompson William F., Spiker Steven, Allen George C., Matrix Attachment Regions and Transcriptional Gene Silencing, in Annual Plant Reviews online, 2018. Crossref
-
Jin Yan, Liu Zheng, Cao Wei, Ma Xinying, Fan Yihui, Yu Yang, Bai Jing, Chen Feng, Rosales Jesusa, Lee Ki-Young, Fu Songbin, Guan Xin-yuan, Novel Functional MAR Elements of Double Minute Chromosomes in Human Ovarian Cells Capable of Enhancing Gene Expression, PLoS ONE, 7, 2, 2012. Crossref
-
Wu Geng, Xu Rongyao, Zhang Ping, Xiao Tao, Fu Yu, Zhang Yuchao, Du Yifei, Ye Jinhai, Cheng Jie, Jiang Hongbing, Estrogen regulates stemness and senescence of bone marrow stromal cells to prevent osteoporosis via ERβ‐SATB2 pathway, Journal of Cellular Physiology, 233, 5, 2018. Crossref
-
Sun Hangjun, Liu Xiaowei, Li Fangfang, Li Wei, Zhang Jing, Xiao Zhixin, Shen Lili, Li Ying, Wang Fenglong, Yang Jinguang, First comprehensive proteome analysis of lysine crotonylation in seedling leaves of Nicotiana tabacum , Scientific Reports, 7, 1, 2017. Crossref
-
Kishimoto Naoki, Nagai Jun-ichi, Kinoshita Takehito, Ueno Keiichiro, Ohashi Yuko, Mitsuhara Ichiro, Lin Baochuan, DNA Elements Reducing Transcriptional Gene Silencing Revealed by a Novel Screening Strategy, PLoS ONE, 8, 1, 2013. Crossref
-
Wotton David, Pemberton Lucy F., Merrill-Schools Jacqueline, SUMO and Chromatin Remodeling, in SUMO Regulation of Cellular Processes, 963, 2017. Crossref
-
Chernov I.P., Akopov S.B., Nikolaev L.G., Sverdlov E.D., Identification and mapping of nuclear matrix-attachment regions in a one megabase locus of human chromosome 19q13.12: Long-range correlation of S/MARs and gene positions, Journal of Cellular Biochemistry, 84, 3, 2002. Crossref
-
Bode Jürgen, Schlake Thomas, Iber Michaela, Schübeler Dirk, Seibler Jost, Snezhkov Evgeney, Nikolaev Lev, The Transgeneticists Toolbox: Novel Methods for the Targeted Modification of Eukaryotic Genomes, Biological Chemistry, 381, 9-10, 2000. Crossref
-
Han Zongchao, Banworth Marcellus J., Makkia Rasha, Conley Shannon M., Al‐Ubaidi Muayyad R., Cooper Mark J., Naash Muna I., Genomic DNA nanoparticles rescue rhodopsin‐associated retinitis pigmentosa phenotype, The FASEB Journal, 29, 6, 2015. Crossref
-
Zhang Jin, Tu Qisheng, Grosschedl Rudolf, Kim Min Seok, Griffin Terrence, Drissi Hicham, Yang Pishan, Chen Jake, Roles of SATB2 in Osteogenic Differentiation and Bone Regeneration, Tissue Engineering Part A, 17, 13-14, 2011. Crossref
-
Li Qin, Zhao Chun-peng, Lin Yan, Song Chao, Wang Fang, Wang Tian-yun, Two human MARs effectively increase transgene expression in transfected CHO cells, Journal of Cellular and Molecular Medicine, 23, 2, 2019. Crossref
-
Wotton David, Merrill Jacqueline C., SUMO and Chromatin Remodelling, in SUMO Regulation of Cellular Processes, 2009. Crossref
-
Hagedorn Claudia, Lipps Hans J., Rupprecht Sina, The epigenetic regulation of autonomous replicons, BioMolecular Concepts, 1, 1, 2010. Crossref
-
Gluch A., Vidakovic M., Bode J., Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy, in Protein-Protein Interactions as New Drug Targets, 186, 2008. Crossref
-
Kim Helen, Laudemann John, Stevens Jennitte, Wu Michelle, Expression Vector Engineering for Recombinant Protein Production, in Cell Line Development, 6, 2009. Crossref
-
Nandi Somen, Khush Gurdev S., Strategies to Increase Heterologous Protein Expression in Rice Grains, in Recent Advancements in Gene Expression and Enabling Technologies in Crop Plants, 2015. Crossref
-
Botezatu L., Sievers S., Gama-Norton L., Schucht R., Hauser H., Wirth D., Genetic Aspects of Cell Line Development from a Synthetic Biology Perspective, in Genomics and Systems Biology of Mammalian Cell Culture, 2011. Crossref
-
Wade-Martins Richard, Developing Extrachromosomal Gene Expression Vector Technologies: An Overview, in Mammalian Chromosome Engineering, 738, 2011. Crossref
-
Neri Queenie V., Hu Jennifer, Rosenwaks Zev, Palermo Gianpiero D., Understanding the Spermatozoon, in Human Fertility, 1154, 2014. Crossref
-
B.T. Matsaunyane Lerato, A. Dubery Ian, Molecular Approaches to Address Intended and Unintended Effects and Substantial Equivalence of Genetically Modified Crops, in Transgenic Crops - Emerging Trends and Future Perspectives, 2019. Crossref
-
Ayusawa Dai, Therapeutic Induction of Cellular Senescence: Nuclear Matrix in Senescence, in Aging of Cells in and Outside the Body, 2003. Crossref
-
Zhang Jihong, Zhang Junhe, Cheng Shan, Yang Wenwen, Li Shijiang, Enhanced transgene expression using two β-globin MARs flanking expression cassettes in stably transfected CHO-K1 cells, 3 Biotech, 9, 11, 2019. Crossref
-
Wasserman Wyeth W., Krivan William, In silico identification of metazoan transcriptional regulatory regions, Naturwissenschaften, 90, 4, 2003. Crossref
-
Yew Nelson, Cheng Seng, Sustaining Transgene Expression in Vivo, in Pharmaceutical Gene Delivery Systems, 20035023, 2003. Crossref
-
Izumi Hiroto, Funa Keiko, Telomere Function and the G-Quadruplex Formation are Regulated by hnRNP U, Cells, 8, 5, 2019. Crossref
-
Jenke Bok Hee C, Fetzer Christian P, Stehle Isa M, Jönsson Franziska, Fackelmayer Frank O, Conradt Harald, Bode Jürgen, Lipps Hans J, An episomally replicating vector binds to the nuclear matrix protein SAF‐A in vivo , EMBO reports, 3, 4, 2002. Crossref
-
Ramezani Ali, Hawley Teresa S., Hawley Robert G., Performance- and safety-enhanced lentiviral vectors containing the human interferon-β scaffold attachment region and the chicken β-globin insulator, Blood, 101, 12, 2003. Crossref
-
Liew Pei Sheng, Tan Tze Hao, Wong Yin Cheng, Sim Edmund Ui Hang, Lee Choon Weng, Narayanan Kumaran, A Self-Replicating Linear DNA, ACS Synthetic Biology, 9, 4, 2020. Crossref
-
Schaufele Fred, Chang Ching-yi, Liu Weiqun, Baxter John D., Nordeen Steven K., Wan Yihong, Day Richard N., McDonnell Donald P., Temporally Distinct and Ligand-Specific Recruitment of Nuclear Receptor-Interacting Peptides and Cofactors to Subnuclear Domains Containing the Estrogen Receptor, Molecular Endocrinology, 14, 12, 2000. Crossref
-
KUMAR SURESH, Computational interaction study of scaffold/ matrix attachment regions (S/MARS) with nuclear matrix Protein in human chromosome 3 Contactin 4(CNTN4) gene, International Journal of Pharma and Bio Sciences, 9, 1, 2018. Crossref
-
Ma Yue, Ramezani Ali, Lewis Rachel, Hawley Robert G., Thomson James A., High‐Level Sustained Transgene Expression in Human Embryonic Stem Cells Using Lentiviral Vectors, STEM CELLS, 21, 1, 2003. Crossref
-
Zaidi S. Kaleem, Javed Amjad, Choi Je-Yong, van Wijnen André J., Stein Janet L., Lian Jane B., Stein Gary S., A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene, Journal of Cell Science, 114, 17, 2001. Crossref
-
Eick Dirk, Geyer Matthias, The RNA Polymerase II Carboxy-Terminal Domain (CTD) Code, Chemical Reviews, 113, 11, 2013. Crossref
-
Razin Sergey V, Matrix‐associated Regions (MARs) and Scaffold Attachment Regions (SARs), in eLS, 2005. Crossref
-
Linnemann A.K., Platts A.E., Doggett N., Gluch A., Bode J., Krawetz S.A., Genomewide identification of nuclear matrix attachment regions: an analysis of methods, Biochemical Society Transactions, 35, 3, 2007. Crossref
-
Haase Rudolf, Argyros Orestis, Wong Suet-Ping, Harbottle Richard P, Lipps Hans J, Ogris Manfred, Magnusson Terese, Pinto Maria G Vizoso, Haas Jürgen, Baiker Armin, pEPito: a significantly improved non-viral episomal expression vector for mammalian cells, BMC Biotechnology, 10, 1, 2010. Crossref
-
Elcock Lauren S., Bridger Joanna M., Exploring the effects of a dysfunctional nuclear matrix, Biochemical Society Transactions, 36, 6, 2008. Crossref
-
Gödecke Natascha, Herrmann Sabrina, Hauser Hansjörg, Mayer-Bartschmid Anke, Trautwein Mark, Wirth Dagmar, Rational Design of Single Copy Expression Cassettes in Defined Chromosomal Sites Overcomes Intraclonal Cell-to-Cell Expression Heterogeneity and Ensures Robust Antibody Production, ACS Synthetic Biology, 10, 1, 2021. Crossref
-
Nehlsen Kristina, Schucht Roland, da Gama-Norton Leonor, Krömer Wolfgang, Baer Alexandra, Cayli Aziz, Hauser Hansjörg, Wirth Dagmar, Recombinant protein expression by targeting pre-selected chromosomal loci, BMC Biotechnology, 9, 1, 2009. Crossref
-
Nikolakaki Eleni, Kohen Rachel, Hartmann Annette M., Stamm Stefan, Georgatsou Elena, Giannakouros Thomas, Cloning and Characterization of an Alternatively Spliced Form of SR Protein Kinase 1 That Interacts Specifically with Scaffold Attachment Factor-B, Journal of Biological Chemistry, 276, 43, 2001. Crossref
-
Frisch Matthias, Frech Kornelie, Klingenhoff Andreas, Cartharius Kerstin, Liebich Ines, Werner Thomas, In Silico Prediction of Scaffold/Matrix Attachment Regions in Large Genomic Sequences, Genome Research, 12, 2, 2002. Crossref
-
Petrov Andrei, Allinne Jeanne, Pirozhkova Iryna, Laoudj Dalila, Lipinski Marc, Vassetzky Yegor S., A nuclear matrix attachment site in the 4q35 locus has an enhancer-blocking activity in vivo: Implications for the facio-scapulo-humeral dystrophy, Genome Research, 18, 1, 2008. Crossref
-
Torrungruang Kitti, Alvarez Marta, Shah Rita, Onyia Jude E., Rhodes Simon J., Bidwell Joseph P., DNA Binding and Gene Activation Properties of the Nmp4 Nuclear Matrix Transcription Factors, Journal of Biological Chemistry, 277, 18, 2002. Crossref
-
Patani Neill, Jiang Wen, Mansel Robert, Newbold Robert, Mokbel Kefah, The mRNA expression of SATB1 and SATB2 in human breast cancer, Cancer Cell International, 9, 1, 2009. Crossref
-
Zhang Rui, Lai Weiyi, Wang Hailin, Quantification of Epigenetic DNA Modifications in the Subchromatin Structure Matrix Attachment Regions by Stable Isotope Dilution UHPLC-MS/MS Analysis, Analytical Chemistry, 93, 47, 2021. Crossref
-
Toualbi Lyes, Toms Maria, Moosajee Mariya, The Landscape of Non-Viral Gene Augmentation Strategies for Inherited Retinal Diseases, International Journal of Molecular Sciences, 22, 5, 2021. Crossref
-
Heng Henry H. Q., Goetze Sandra, Ye Christine J., Liu Guo, Stevens Joshua B., Bremer Steven W., Wykes Susan M., Bode Juergen, Krawetz Stephen A., Chromatin loops are selectively anchored using scaffold/matrix-attachment regions, Journal of Cell Science, 117, 7, 2004. Crossref
-
Shera Katherine A., Shera Christopher A., McDougall James K., Small Tumor Virus Genomes Are Integrated near Nuclear Matrix Attachment Regions in Transformed Cells, Journal of Virology, 75, 24, 2001. Crossref
-
Goetze S., Gluch A., Benham C., Bode J., Computational and in Vitro Analysis of Destabilized DNA Regions in the Interferon Gene Cluster: Potential of Predicting Functional Gene Domains, Biochemistry, 42, 1, 2003. Crossref
-
Townson Steven M., Kang Kaiyan, Lee Adrian V., Oesterreich Steffi, Structure-Function Analysis of the Estrogen Receptor α Corepressor Scaffold Attachment Factor-B1, Journal of Biological Chemistry, 279, 25, 2004. Crossref
-
Singh Kamini, Sinha Surajit, Malonia Sunil Kumar, Bist Pradeep, Tergaonkar Vinay, Chattopadhyay Samit, Tumor Suppressor SMAR1 Represses IκBα Expression and Inhibits p65 Transactivation through Matrix Attachment Regions, Journal of Biological Chemistry, 284, 2, 2009. Crossref
-
Suzuki Toshikazu, Michishita Eriko, Ogino Hideki, Fujii Michihiko, Ayusawa Dai, Synergistic Induction of the Senescence-Associated Genes by 5-Bromodeoxyuridine and AT-Binding Ligands in HeLa Cells, Experimental Cell Research, 276, 2, 2002. Crossref
-
Argyros Orestis, Wong Suet‐Ping, Coutelle Charles, Harbottle Richard P., Utilizing Minicircle Vectors for the Episomal Modification of Cells, in Minicircle and Miniplasmid DNA Vectors, 2013. Crossref
-
Tark‐Dame Mariliis, Luijsterburg Martijn S., Heermann Dieter W., van Driel Roel, Understanding Genome Function: Quantitative Modeling of Chromatin Folding and Chromatin‐Associated Processes, in Genome Organization and Function in the Cell Nucleus, 2011. Crossref
-
Antoniv Taras T., De Val Sarah, Wells Dominic, Denton Christopher P., Rabe Christian, de Crombrugghe Benoit, Ramirez Francesco, Bou-Gharios George, Characterization of an Evolutionarily Conserved Far-upstream Enhancer in the Human α2(I) Collagen (COL1A2) Gene, Journal of Biological Chemistry, 276, 24, 2001. Crossref
-
Buceta M, Galbete J L, Kostic C, Arsenijevic Y, Mermod N, Use of human MAR elements to improve retroviral vector production, Gene Therapy, 18, 1, 2011. Crossref
-
Adhikary Arghya, Chakraborty Samik, Mazumdar Minakshi, Ghosh Swatilekha, Mukherjee Shravanti, Manna Argha, Mohanty Suchismita, Nakka Kiran Kumar, Joshi Shruti, De Abhijit, Chattopadhyay Samit, Sa Gaurisankar, Das Tanya, Inhibition of Epithelial to Mesenchymal Transition by E-cadherin Up-regulation via Repression of Slug Transcription and Inhibition of E-cadherin Degradation, Journal of Biological Chemistry, 289, 37, 2014. Crossref
-
Nehlsen Kristina, Broll Sandra, Kandimalla Raju, Heinz Niels, Heine Markus, Binius Stefanie, Schambach Axel, Bode Jürgen, Replicating Minicircles: Overcoming the Limitations of Transient and Stable Expression Systems, in Minicircle and Miniplasmid DNA Vectors, 2013. Crossref
-
Figlan Sandiswa, Mwadzingeni Learnmore, Breeding Tools for Assessing and Improving Resistance and Limiting Mycotoxin Production by Fusarium graminearum in Wheat, Plants, 11, 15, 2022. Crossref
-
Sureka Rahul, Avvaru Akshay Kumar, Sowpati Divya Tej, Pathak Rashmi Upadhyay, Mishra Rakesh Kumar, Structural and developmental dynamics of Matrix associated regions in Drosophila melanogaster genome, BMC Genomics, 23, 1, 2022. Crossref
-
Goebel Peter, Montalbano Alina, Ayers Neil, Kompfner Elizabeth, Dickinson Liliane, Webb Carol F., Feeney Ann J., High Frequency of Matrix Attachment Regions and Cut-Like Protein x/CCAAT-Displacement Protein and B Cell Regulator of IgH Transcription Binding Sites Flanking Ig V Region Genes, The Journal of Immunology, 169, 5, 2002. Crossref