图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
真核基因表达评论综述™
影响因子: 1.841 5年影响因子: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukarGeneExpr.v5.i3-4.20
pages 219-253

Regulation and Regulatory Role of the Retinoids

Kong Wan Ng
Department of Medicine, The University of Melbourne, St Vincent's Hospital, Fitzroy 3065, Australia
Hong Zhou
Department of Medicine, The University of Melbourne, St Vincent's Hospital, Fitzroy 3065, Australia
Shehnaaz Manji
Department of Medicine, The University of Melbourne, St Vincent's Hospital, Fitzroy 3065, Australia
T. John Martin
St. Vincent's Institute of Medical Research and University of Melbourne Department of Medicine, Fitzroy, 3065, Victoria, Australia

ABSTRACT

Retinoids regulate differentiation and cellular growth, exerting their physiological action by interacting with two families of nuclear receptors, the retinoic acid receptors (RARs), and the retinoid X receptors (RXRs), which regulate gene expression by forming transcriptionally active heterodimeric RAR/RXR or homodimeric RXR/RXR complexes on DNA. Although RAR/RXR heterodimers form preferentially in vitro and in vivo, it does not exclude the possibility that RXR/RXR homodimers may regulate a distinct signaling pathway. Synthetic retinoids that selectively activate or antagonize retinoic acid receptor isoforms promises to be useful tools for the elucidation of specific retinoid response pathways. Considerable progress has been made in understanding the molecular basis underlying limb bud formation, particularly the manner in which retinoic acid interacts with other signaling molecules to determine pattern formation. The phenotypic abnormalities observed in compound null mutants of retinoid receptors, recapitulating those described in the vitamin A deficiency syndrome, confirm the crucial function of endogenous retinoids in fetal development. However, the absence of phenotypic abnormalities in null mutants of individual RAR isoforms raises the possibility of functional redundancy among RAR subtypes and at the same time challenging the concept that the diverse effects of retinoids are related to the multiplicity of functionally distinct receptors.


Articles with similar content:

Retinoid-Regulated Gene Expression in Neural Development
Critical Reviews™ in Eukaryotic Gene Expression, Vol.7, 1997, issue 4
Margaret Clagett-Dame, Lori A. Plum
The VAV Family of Signal Transduction Molecules
Critical Reviews™ in Oncogenesis, Vol.7, 1996, issue 1-2
Xose R. Bustelo
Structural and Expression Changes of Septins in Myeloid Neoplasia
Critical Reviews™ in Oncogenesis, Vol.15, 2009, issue 1-2
Nuno Cerveira, Joana Santos, Manuel R. Teixeira
Transcription Regulator Yin-Yang 1: From Silence to Cancer
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 3-4
Weidong Zhu, Hermes Garban, Samuel Y. Olson
Caught in the Act: Binding of Ku and PARP to MARs Reveals Novel Aspects of Their Functional Interaction
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 1
Terumi Kohwi-Shigematsu, Sanjeev Galande