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ISSN 打印: 1045-4403

ISSN 在线: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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ALDOB Acts as a Novel HBsAg-Binding Protein and Its Coexistence Inhibits Cisplatin-Induced HepG2 Cell Apoptosis

卷 24, 册 3, 2014, pp. 181-191
DOI: 10.1615/CritRevEukaryotGeneExpr.2014010087
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摘要

Chronic infection with hepatitis B virus is a cause of end-stage liver disease and hepatocellular carcinoma (HCC). We previously screened fructose-bisphosphate aldolase B (ALDOB) as a candidate binding protein of hepatitis B surface antigen (HBsAg) using a yeast 2-hybrid assay. In this study we aimed to confirm ALDOB as a binding protein of the S region of the HbsAg (HBs) and to investigate the function and involved mechanism between its interactions during HCC development. Our results demonstrated that both of exogenous and endogenous ALDOB proteins bind to HBs and colocalize in the cytoplasm in vitro. The coexistence of HBs and ALDOB inhibit apoptosis of cisplatin-induced HepG2 cells. Furthermore, western blot analysis showed the coexistence of HBs and ALDOB enhance the phosphorylations of AKT and its downstream of GSK-3β (phosphorylation); decreased expression of the pro-apoptotic proteins Bax, Bid, Bim, and Puma; and increased expression of the prosur-vival proteins Bcl-2, Bcl-xl, and Mcl-1 in HepG2 cells. These findings suggest that interaction between HBs and ALDOB might be applied as a potential therapeutic target during the treatment of HBV-related hepatitis or HCC.

对本文的引用
  1. Chang Yu-Chan, Yang Yi-Chieh, Tien Chia-Ping, Yang Chih-Jen, Hsiao Michael, Roles of Aldolase Family Genes in Human Cancers and Diseases, Trends in Endocrinology & Metabolism, 29, 8, 2018. Crossref

  2. Zhu Yi, Zhu Jiang, Lu Cong, Zhang Qiushi, Xie Wei, Sun Ping, Dong Xiaochuan, Yue Liang, Sun Yaoting, Yi Xiao, Zhu Tiansheng, Ruan Guan, Aebersold Ruedi, Huang Shi'ang, Guo Tiannan, Identification of Protein Abundance Changes in Hepatocellular Carcinoma Tissues Using PCT–SWATH, PROTEOMICS – Clinical Applications, 13, 1, 2019. Crossref

  3. Hawkins Liam J., Wang Minjing, Zhang Baowen, Xiao Qi, Wang Hui, Storey Kenneth B., Glucose and urea metabolic enzymes are differentially phosphorylated during freezing, anoxia, and dehydration exposures in a freeze tolerant frog, Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 30, 2019. Crossref

  4. Sun Yufeng, Li Wenchao, Shen Shiqi, Yang Xuejing, Lu Bing, Zhang Xiaojing, Lu Peng, Shen Yi, Ji Juling, Loss of alanine-glyoxylate and serine-pyruvate aminotransferase expression accelerated the progression of hepatocellular carcinoma and predicted poor prognosis, Journal of Translational Medicine, 17, 1, 2019. Crossref

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