每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
IF:
1.6
5-Year IF:
2.2
Immediacy Index:
0.3
Eigenfactor:
0.00058
JCI:
0.33
SJR:
0.345
SNIP:
0.46
CiteScore™::
2.5
H-Index:
67
Indexed in
A Kinetic Overview of the Receptors Involved in 1,25-Dihydroxyvitamin D3 and 24,25-Dihydroxyvitamin D3 Signaling: A Systems Biology Approach
Get access
摘要
The vitamin D endocrine system modulates an arsenal of important biological functions in more than 30 different tissues in short- and long-term perspectives. Two membrane receptors and one nuclear receptor are suggested to be involved in the vitamin D signaling system, but the function and physiological relevance of the receptors are debated. The complexity of the vitamin D endocrine system makes it necessary to combine experimental data with in silico simulations to get a holistic view of vitamin D−dependent regulation of tissue and cell physiology. This review focus on binding characteristics for the three putative vitamin D receptors and proposes a future systems biology approach including mathematical modeling that will be helpful together with experimental methods in depicting antitumoral and other biological effects promoted by the vitamin D endocrine system.
-
Jorde Rolf, Svartberg Johan, Joakimsen Ragnar Martin, Coucheron Dag H, Plasma profile of microRNA after supplementation with high doses of vitamin D3 for 12 months, BMC Research Notes, 5, 1, 2012. Crossref
-
de Paula Francisco J.A., Rosen Clifford J., Vitamin D and Fat, in Vitamin D, 2011. Crossref
-
Karlsson Sandra, Olausson Josefin, Lundh Dan, Sögård Peter, Mandal Abul, Holmström Kjell-Ove, Stahel Anette, Bengtsson Jenny, Larsson Dennis, Vitamin D and prostate cancer: The role of membrane initiated signaling pathways in prostate cancer progression, The Journal of Steroid Biochemistry and Molecular Biology, 121, 1-2, 2010. Crossref
-
de Paula Francisco J. A., Dick-de-Paula Ingrid, Bornstein Sheila, Rostama Bahman, Le Phuong, Lotinun Sutada, Baron Roland, Rosen Clifford J., VDR Haploinsufficiency Impacts Body Composition and Skeletal Acquisition in a Gender-Specific Manner, Calcified Tissue International, 89, 3, 2011. Crossref
-
Rosen Clifford J., Adams John S., Bikle Daniel D., Black Dennis M., Demay Marie B., Manson JoAnn E., Murad M. Hassan, Kovacs Christopher S., The Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement, Endocrine Reviews, 33, 3, 2012. Crossref
-
Diaz Cruz Maria Araceli, Karlsson Sandra, Szekeres Ferenc, Faresjö Maria, Lund Dan, Larsson Dennis, Differential expression of protein disulfide-isomerase A3 isoforms, PDIA3 and PDIA3N, in human prostate cancer cell lines representing different stages of prostate cancer, Molecular Biology Reports, 48, 3, 2021. Crossref