图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
雾化与喷雾
影响因子: 1.737 5年影响因子: 1.518 SJR: 0.814 SNIP: 1.18 CiteScore™: 2.2

ISSN 打印: 1044-5110
ISSN 在线: 1936-2684

卷:
卷 30, 2020 卷 29, 2019 卷 28, 2018 卷 27, 2017 卷 26, 2016 卷 25, 2015 卷 24, 2014 卷 23, 2013 卷 22, 2012 卷 21, 2011 卷 20, 2010 卷 19, 2009 卷 18, 2008 卷 17, 2007 卷 16, 2006 卷 15, 2005 卷 14, 2004 卷 13, 2003 卷 12, 2002 卷 11, 2001 卷 10, 2000 卷 9, 1999 卷 8, 1998 卷 7, 1997 卷 6, 1996 卷 5, 1995 卷 4, 1994 卷 3, 1993 卷 2, 1992 卷 1, 1991

雾化与喷雾

DOI: 10.1615/AtomizSpr.v20.i9.20
pages 763-774

TAILORING DRY POWDER INHALER PERFORMANCE BY MODIFYINGCARRIER SURFACE TOPOGRAPHY BY SPRAY DRYING

Stephan G. Maas
Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany
Gerhard Schaldach
Department of Biochemical and Chemical Engineering, Technische Universitaet Dortmund Emil-Figge-Strasse 68, 44227 Dortmund, Germany
Peter Walzel
Department of Biochemical and Chemical Engineering, Technische Universitaet Dortmund, Emil-Figge-Strasse 68, Dortmund, 44227, Germany
Nora Anne Urbanetz
Research Center Pharmaceutical Enfineering GmbH, Institute of Process and Particle Technology, Graz University of Technology, Austria

ABSTRACT

In order to provide adequate performance of dry powder inhalates with respect to dosing and fine particle fraction, interparticle adhesion between drug and carrier has to be well balanced. It has to be large enough to ensure attachment of the active ingredient during powder handling and dosing, but small enough to ensure detachment of the drug from the carrier on inhalation. In this study, interparticle interactions have been modified by targeting the surface topography of the carrier or rather the contact area between drug and carrier using spray drying. Because lactose is susceptible to spray drying, resulting in partial or full amorphicity, mannitol was used here. The spray drying outlet temperature turned out to be an appropriate parameter to affect surface topography, spray drying at low temperature leading to smooth particles, and spray drying at high temperature leading to rough particle surfaces. Dosing of the inhalate was found not to be affected by surface roughness of the carrier. However, the fine particle fraction decreases with increasing surface roughness. Consequently, the use of mannitol carrier particles exhibiting different surface topographies allows for modifying interparticle interactions, thereby providing an effective tool for tailoring the performance of an inhalate.


Articles with similar content:

ADVECTION FEATURES OF WATER SURFACE PROFILE IN TURBULENT OPEN-CHANNEL FLOW WITH HEMISPHERE ROUGHNESS ELEMENTS
Visualization of Mechanical Processes: An International Online Journal, Vol.1, 2011, issue 4
Y. Furutani, Ichiro Fujita, T. Okanishi
Pharmaceutical Approaches to Preparing Pelletized Dosage Forms Using the Extrusion-Spheronization Process
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.24, 2007, issue 1
Maria Gerald Rajan, James R. Johnson, Atul J. Shukla, Namrata R. Trivedi
Dawn of Advanced Molecular Medicine: Nanotechnological Advancements in Cancer Imaging and Therapy
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 3-4
Travis M. Shaffer, Daniel L. J. Thorek , Charalambos Kaittanis, Jan Grimm
Extrusion-Spheronization: Process Variables and Characterization
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 3
A. Agarwal, Gurpreet Singh, Vivek Ranjan Sinha, M. K. Agrawal, D. Ghai
Distributed Intracellular Process Modeling Using Active Charged Particles
Journal of Automation and Information Sciences, Vol.44, 2012, issue 6
Boris A Biletskyy