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等离子医学
SJR: 0.278 SNIP: 0.183 CiteScore™: 0.57

ISSN 打印: 1947-5764
ISSN 在线: 1947-5772

等离子医学

DOI: 10.1615/PlasmaMed.v1.i1.10
pages 3-19

Cold Spark Discharge Plasma Treatment of Inflammatory Bowel Disease in an Animal Model of Ulcerative Colitis

Kalyan Chakravarthy
School of Biomedical Engineering, Science and Health Systems, Drexel University, USA
Danil Dobrynin
C&J Nyheim Plasma Institute, Drexel University, Camden NJ 08103
Gregory Fridman
C&J Nyheim Plasma Institute, Drexel University, Camden, New Jersey 08103
Gary Friedman
Department of Electrical and Computer Engineering, College of Engineering, A. J. Drexel Plasma Institute, Drexel University, Philadelphia, Pennsylvania
Sreekant Murthy
College of Medicine, Drexel University, USA
Alexander A. Fridman
C&J Nyheim Plasma Institute, Drexel University, Camden, New Jersey 08103

ABSTRACT

Cold plasma discharges have been shown to have medically-relevant therapeutic effects when applied to living tissues, including blood coagulation and wound healing; thus, plasma treatment of inflamed tissues in ulcerative colitis disease may be an effective approach to reduce adverse consequences if not cure the disease. Here we discuss results of the first experimental study of cold plasma treatment of ulcerative colitis in a mouse model. As a plasma source, a cold spark discharge has been used. The results show that plasma treatment of experimental model of ulcerative colitis in mice has some beneficial effects by suppressing the progression of the disease while no damage to colon tissues is observed; and these effects are comparable to standard therapy.