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等离子医学
SJR: 0.278 SNIP: 0.183 CiteScore™: 0.57

ISSN 打印: 1947-5764
ISSN 在线: 1947-5772

等离子医学

DOI: 10.1615/PlasmaMed.2011002698
pages 109-114

Cold Plasma Sterilization of Open Wounds: Live Rat Model

Danil Dobrynin
C&J Nyheim Plasma Institute, Drexel University, Camden NJ 08103
Kimberly Wasko
Department of Surgery, Drexel University College of Medicine, Philadelphia, PA, USA
Gary Friedman
Department of Electrical and Computer Engineering, College of Engineering, A. J. Drexel Plasma Institute, Drexel University, Philadelphia, Pennsylvania
Alexander A. Fridman
C&J Nyheim Plasma Institute, Drexel University, Camden, New Jersey 08103
Gregory Fridman
C&J Nyheim Plasma Institute, Drexel University, Camden, New Jersey 08103

ABSTRACT

Atmospheric pressure non-equilibrium (cold) plasmas are already known to be effective sterilization agents. This work further confirms the ability of cold plasma to inactivate pathogenic organisms in a live animal model. The rat wound model used here represents a surgical treatment situation whereby the wound is open and the bleeding is controlled. High concentration of Staphylococcus aureus is placed onto the wound area and allowed to incubate for four hours prior to cold plasma treatment. We show a 3-log reduction in pathogen load on the wound following a one minute treatment.