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ISSN 打印: 1947-5764

ISSN 在线: 1947-5772

SJR: 0.216 SNIP: 0.263 CiteScore™:: 1.4 H-Index: 24

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Acute Rat Cutaneous Wound Healing for Small and Large Wounds Using Ar/O2 Atmospheric-Pressure Plasma Jet Treatment

卷 7, 册 3, 2017, pp. 227-243
DOI: 10.1615/PlasmaMed.2017020386
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摘要

In this study, we developed a rat model of acute wound healing treated by a cold and touchable Ar/O2 atmospheric-pressure plasma jet (APPJ) with a jet gas temperature of < 37%C and a length of 15 mm. To generate more abundant reactive oxygen species (ROS) and reactive nitrogen species (RNS), we added various amounts of oxygen into argon. We have found that, with 0.04% oxygen addition, the APPJ can generate the most abundant ROS/ RNS such as hydroxyl radicals (OH*), N22nd+, and O atom in the jet region based on the optical emission spectroscopymeasurements. We then applied the APPJ to treat open wounds of rats directly. To demonstrate the effectiveness of this APPJ treatment for wound healing, we created two wound sizes with diameters of 8 mm (small) and 21 mm (large). The results show that APPJ treatment with 0.04% oxygen addition can greatly accelerate wound healing, especially for the group with large wounds compared with the control group without any treatment. We explain this wound-healing enhancement with plasma jet treatment using a standard histologic method, hematoxylin and eosin staining, from the sectioned skins by comparing the different experimental groups.

对本文的引用
  1. Cheng Kuang-Yao, Lin Zhi-Hua, Cheng Yu-Pin, Chiu Hsien-Yi, Yeh Nai-Lun, Wu Tung-Kung, Wu Jong-Shinn, Wound Healing in Streptozotocin-Induced Diabetic Rats Using Atmospheric-Pressure Argon Plasma Jet, Scientific Reports, 8, 1, 2018. Crossref

  2. Tschang Chen-Yon Tobias, Thoma Markus, In vitrocomparison of direct plasma treatment and plasma activated water onEscherichia coliusing a surface micro-discharge, Journal of Physics D: Applied Physics, 53, 5, 2020. Crossref

  3. Xia Wenjie, Liu Dingxin, Guo Li, Wang Weitao, Xu Han, Feng Chao, Wang Xiaohua, Kong Michael G, Rong Mingzhe, Discharge characteristics and bactericidal mechanism of Ar plasma jet with ethanol and oxygen gas admixtures, Plasma Sources Science and Technology, 28, 12, 2019. Crossref

  4. Przekora Agata, Audemar Maïté, Pawlat Joanna, Canal Cristina, Thomann Jean-Sébastien, Labay Cédric, Wojcik Michal, Kwiatkowski Michal, Terebun Piotr, Ginalska Grazyna, Hermans Sophie, Duday David, Positive Effect of Cold Atmospheric Nitrogen Plasma on the Behavior of Mesenchymal Stem Cells Cultured on a Bone Scaffold Containing Iron Oxide-Loaded Silica Nanoparticles Catalyst, International Journal of Molecular Sciences, 21, 13, 2020. Crossref

  5. Morabit Youssef, Hasan Mohammad I., Whalley Richard D., Robert Eric, Modic Martina, Walsh James L., A review of the gas and liquid phase interactions in low-temperature plasma jets used for biomedical applications, The European Physical Journal D, 75, 1, 2021. Crossref

  6. Chiu Po-Hsien, Wu Ching-Jung, Hsiao Chun-Ping, Liu Chih-Tung, Wu Mu-Chien, Wu Jong-Shinn, Plasma-Induced Hemi-Wicking on Sanded Polymer Surfaces, Coatings, 11, 8, 2021. Crossref

  7. Peng Cheng-Yun, Wu Jong-Shinn, Tsai Chia-Hung Dylan, Wettability Distribution on the Surface Treated by Plasma Jet at Different Flow Rates for Microfluidic Applications, IEEE Transactions on Plasma Science, 49, 1, 2021. Crossref

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