图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
生物医学工程评论综述™
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN 打印: 0278-940X
ISSN 在线: 1943-619X

生物医学工程评论综述™

DOI: 10.1615/CritRevBiomedEng.2015012287
pages 61-95

Microstimulation: Principles, Techniques, and Approaches to Somatosensory Neuroprosthesis

Mulugeta Semework
Department of Neuroscience, Columbia University, 1051 Riverside Dr., Unit 87, New York, NY, 10032

ABSTRACT

The power of movement of electrically charged particles has been used to alleviate an array of illnesses and help control some human body parts. Microstimulation, the electrical current−driven excitation of neural elements, is now being aimed at brain−machine interfaces (BMIs), brain-controlled external devices that improve quality of life for people such as those who have lost the ability to use their limbs. This effort is motivated by behavioral experiments that indicate a direct link between microstimulation-induced sensory experience and behavior, pointing to the possibility of optimizing and controlling the outputs of BMIs. Several laboratories have focused on using electrical stimulation to return somatosensory feedback from prosthetic limbs directly to the user's central nervous system. However, the difficulty of the problem has led to limited success thus far, and there is a need for a better understanding of the basic principles of neural microstimulation. This article provides a review of the available literature and some recent work at Downstate Medical Center and Columbia University on microstimulation of the primate and rodent somatosensory (S1) cortex and the ventral posterolateral thalamus. It is aimed at contributing to the existing knowledge base to generate good behavioral responses and effective, BMI-appropriate somatosensory feedback. In general, the threshold for the particular brain tissue in response to current−amplitude has to be determined by rigorous experimentation. For consistently reproducible results, hardware and thresholds for microstimulation have to be specified. In addition, effects on motor functions, including unwanted side effects in response to the microstimulation of brain tissue, must be examined to take the field from bench to bedside.


Articles with similar content:

Transcranial Magnetic Stimulation: Physics, Electrophysiology, and Applications
Critical Reviews™ in Biomedical Engineering, Vol.36, 2008, issue 5-6
Ali Fatemi-Ardekani
BRIEF SURVEY OF ANALYTICS IN K12 AND HIGHER EDUCATION
International Journal on Innovations in Online Education, Vol.1, 2017, issue 1
Ananda Gunawardena
A Review of Clinical Balance Tools for Use With Elderly Populations
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.15, 2003, issue 3&4
Anne Cowley, Kate Kerr
Management of Bowel Dysfunction in Neurological Rehabilitation - A Review
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.19, 2007, issue 4
Raji Thomas, Barbara Chandler
Uncovering the Mechanisms of Deep Brain Stimulation for Parkinson's Disease through Functional Imaging, Neural Recording, and Neural Modeling
Critical Reviews™ in Biomedical Engineering, Vol.30, 2002, issue 4-6
Nitish V. Thakor, Cameron C. McIntyre