图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
生物医学工程评论综述™
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN 打印: 0278-940X
ISSN 在线: 1943-619X

生物医学工程评论综述™

DOI: 10.1615/CritRevBiomedEng.2017024461
pages 459-472

The Virtual Microbiome: Computational Approaches to the Study of Microbe-Host Interactions

Joshua J. Pothen
Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405
Anne E. Dixon
Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405
Jason H. T. Bates
Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405

ABSTRACT

The GI tract of a normal adult human contains on the order of 1014 foreign living organisms, collectively known as the gut microbiome, the proper maintenance of which is critical for health. Because the gut microbiome is a dynamic system of vast complexity, computational modeling is assuming an increasingly important role in helping us to understand how and why it behaves as it does. In particular, computational models can serve as a rapid, cost-effective means of simulating the microbiome on multiple scales, from that of an individual bacterium to the microbiome as a whole. This not only allows questions to be addressed in ways that are impractical in the experimental laboratory; it also permits competing hypotheses to be interrogated for feasibility before they are subjected to expensive and time-consuming experimental testing. Here we review some of the differential equation–based and agent-based approaches that have been applied to the computational modeling of the gut microbiome and its effects on the rest of the body. The models discussed are helping us understand how the microbiome works as a system, how it maintains its crucial symbiotic relationship with its host, and, in particular, how its malfunctions can lead to a number of important and often serious pathologies.


Articles with similar content:

Introducing Anatomical and Physiological Accuracy in Computerized Anthropometry for Increasing the Clinical Usefulness of Modeling Systems
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.17, 2005, issue 4
Serge Van Sint Jan
Electronic Medical Records (EMRs): Patient Safety and Ethical Considerations
Ethics in Biology, Engineering and Medicine: An International Journal, Vol.3, 2012, issue 1-3
Monique Frize
Product design methodological contribution based on product decisions : Proposition of reference decisionnal process
Flexible Automation and Intelligent Manufacturing, 1997:
Proceedings of the Seventh International FAIM Conference, Vol.0, 1997, issue
Claudine Guidat, Laure Morel, Vincent Boly, Jean Renaud, Valerie Rault-Jacquot
The Scientific Method in an Era of Advocacy
Ethics in Biology, Engineering and Medicine: An International Journal, Vol.1, 2010, issue 4
Daniel A. Vallero, Paul J. Lioy
SEECN: SIMULATING COMPLEX SYSTEMS USING DYNAMIC COMPLEX NETWORKS
International Journal for Multiscale Computational Engineering, Vol.9, 2011, issue 2
Rick Quax, David A. Bader, Peter M. A. Sloot