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生物医学工程评论综述™

每年出版 6 

ISSN 打印: 0278-940X

ISSN 在线: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

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Stealth Engineering for In Vivo Drug Delivery Systems

卷 43, 册 5-6, 2015, pp. 347-369
DOI: 10.1615/CritRevBiomedEng.2016016141
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摘要

In generic terms, a drug delivery substrate (DDS) can be described as a vehicle to transport drug to the point of interest. A DDS that would ideally have the capability to control drug dosage and achieve target specificity, localization, and higher therapeutic efficacy has been pursued as a holy grail in pharmaceutical research. Over the years, diverse classes, structures, and modifications of DDS have been proposed to achieve this aim. One of its major deterrents, however, is rapid elimination of drug by the immune system before intended functionality. Stealth engineering is broadly defined as a method of designing a drug carrier to minimize or delay opsonization until the encapsulated drug is delivered to the intended target. Stealth-engineered DDS has been successful in extending drug circulation lifetime from a few minutes to several days. Currently, this field of research has made much progress since its initiation in 1960s with liposomes to DNA boxes. Activity has also benefited several areas of medicine, where it has been applied in cancer, gene therapy, bone regrowth, and infection treatment. This review covers the progress of some types of DDS that have been published and indexed in major databases (including ScienceDirect, PubMed, and Google Scholar) in the scientific literature.

对本文的引用
  1. Mohapatra Ankita, Harris Michael A., LeVine David, Ghimire Madhav, Jennings Jessica A., Morshed Bashir I., Haggard Warren O., Bumgardner Joel D., Mishra Sanjay R., Fujiwara Tomoko, Magnetic stimulus responsive vancomycin drug delivery system based on chitosan microbeads embedded with magnetic nanoparticles, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106, 6, 2018. Crossref

  2. Mohapatra Ankita, Harris Michael A., Ghimire Madhav, Morshed Bashir I., Jennings Jessica A., Haggard Warren O., Bumgardner Joel D., Mishra Sanjay R., Fujiwara Tomoko, Chitosan microbeads with MNP on printed electrodes for electric stimulus responsive drug delivery, 2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA), 2017. Crossref

  3. Mohapatra Ankita, Wells Carlos, Jennings Amber, Ghimire Madhav, Mishra Sanjay R., Morshed Bashir I., Electric Stimulus-Responsive Chitosan/MNP Composite Microbeads for a Drug Delivery System, IEEE Transactions on Biomedical Engineering, 67, 1, 2020. Crossref

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