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生物医学工程评论综述™
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN 打印: 0278-940X
ISSN 在线: 1943-619X

生物医学工程评论综述™

DOI: 10.1615/CritRevBiomedEng.v40.i4.90
pages 353-361

Sepsis through the Eyes of an Engineer− Why Treatments Have Succeeded and Failed

Jeffrey Jopling
Department of Surgery, Emory University School of Medicine, 1364 Clifton Road, Atlanta, Georgia 30322, USA
Timothy G. Buchman
Emory Center for Critical Care, Emory University School of Medicine, 1364 Clifton Road, Atlanta, Georgia 30322, USA

ABSTRACT

The sepsis syndrome is an old phenomenon. A destructive response to a system disturbance, it manifests as widespread inflammation. Over the past two centuries, biomedical research has identified triggers and described components of the pathways that underlie the sepsis syndrome. Attempts at translating these findings into preventive and therapeutic interventions have met with varying levels of success. In this chapter, we examine the history of sepsis science through an engineering lens. Patterned attempts to intervene in the natural history of the sepsis syndrome will be discussed in parallel with similar, hypothetical adjustments made to a model system from the engineering canon. This juxtaposition will facilitate our review of the history of sepsis science. Using the logic of systems engineering and network science, we propose a way forward.