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生物医学工程评论综述™

每年出版 6 

ISSN 打印: 0278-940X

ISSN 在线: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

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Microbubbles as Ultrasound Contrast Agents and in Targeted Drug Delivery

卷 36, 册 4, 2008, pp. 235-265
DOI: 10.1615/CritRevBiomedEng.v36.i4.10
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摘要

The development of microbubbles has had considerable impact on the field of diagnostic ultrasound. These minute, gas- or lipid-filled spheres have enabled imaging in the kidney, liver, heart, and myocardium with resolutions that were previously unachievable. Insonation of these microagents generates high-energy cavitational oscillations, which, in addition to providing contrast, can increase local drug diffusivity through microstreaming or bubble collapse. The ability of focused insonation to induce such collapse on ligated microbubbles offers opportunities to deliver targeted therapies in novel ways. Microbubbles have had considerable impact on cancer research in terms of both imagining tumors and through the delivery of therapeutic agents and on the delivery of substances across biological obstructions such as the blood-brain barrier. This review offers a discussion of current approaches used in microbubble construction, of the underlying physics involved in their creation and destruction, and of current applications for these particles, the latter demonstrating their importance for high-contrast medical ultrasound. Challenges to overcome and future areas of microbubble application are also discussed.

对本文的引用
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  5. Yue Peijian, Miao Wang, Gao Lin, Zhao Xinyu, Teng Junfang, Ultrasound-Triggered Effects of the Microbubbles Coupled to GDNF Plasmid-Loaded PEGylated Liposomes in a Rat Model of Parkinson's Disease, Frontiers in Neuroscience, 12, 2018. Crossref

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