每年出版 6 期
ISSN 打印: 0278-940X
ISSN 在线: 1943-619X
Indexed in
Motion Compensation in Radiotherapy
摘要
Image-guided radiotherapy (IGRT) has helped to dramatically reduce safety margins compensating for positioning uncertainties in radiotherapy. A remaining issue posing problems for photon radiotherapy (RT), but even more so for particle RT, is target motion during treatment delivery. This review outlines the various strategies currently being developed or already in clinical use to compensate for organ motion, predominantly breathing-induced motion of liver and lung targets. Several motion compensation strategies have recently been introduced clinically. Among these are optimized margins encompassing the individual range of target motion, treatment under breath hold, gated treatments, and tumor tracking with a dedicated treatment device. A variety of surveillance strategies for gating and tracking, such as indirect tracking with external fiducial markers and surface scanning devices, direct tracking with implanted electromagnetic markers, fiducial markers, and fluoroscopy, and ultrasound-based tracking are already in clinical use or are under development. Tracked treatment with linear accelerators based on tumor-synchronous MLC- or treatment-table adaptation are moving toward clinical use. A multitude of strategies to reduce the impact of intrafractional target motion in RT have been developed and are increasingly being used clinically. The clinical introduction of advanced strategies currently under development is imminent. After IGRT minimized treatment margins for static tumors, the implementation of motion compensation strategies will achieve the same for targets being subject to intrafractional breathing-induced motion.
-
Mawlawi Osama R., Court Laurence E., Four-Dimensional PET-CT in Radiation Oncology, PET Clinics, 8, 1, 2013. Crossref
-
Stieler F., Wenz F., Shi M., Lohr F., A novel surface imaging system for patient positioning and surveillance during radiotherapy, Strahlentherapie und Onkologie, 189, 11, 2013. Crossref
-
Knopf Antje, Nill Simeon, Yohannes Indra, Graeff Christian, Dowdell Stephen, Kurz Christopher, Sonke Jan-Jakob, Biegun Aleksandra K., Lang Stephanie, McClelland Jamie, Champion Benjamin, Fast Martin, Wölfelschneider Jens, Gianoli Chiara, Rucinski Antoni, Baroni Guido, Richter Christian, van de Water Steven, Grassberger Clemens, Weber Damien, Poulsen Per, Shimizu Shinichi, Bert Christoph, Challenges of radiotherapy: Report on the 4D treatment planning workshop 2013, Physica Medica, 30, 7, 2014. Crossref
-
Brix Lau, Ringgaard Steffen, Sørensen Thomas Sangild, Poulsen Per Rugaard, Three-dimensional liver motion tracking using real-time two-dimensional MRI, Medical Physics, 41, 4, 2014. Crossref
-
Ilegbusi Olusegun J., Li Zhiliang, Seyfi Behnaz, Min Yugang, Meeks Sanford, Kupelian Patrick, Santhanam Anand P., Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models, International Journal of Biomedical Imaging, 2012, 2012. Crossref
-
Sterzing Florian, Brunner Thomas B., Ernst Iris, Baus Wolfgang W., Greve Burkhard, Herfarth Klaus, Guckenberger Matthias, Stereotactic body radiotherapy for liver tumors, Strahlentherapie und Onkologie, 190, 10, 2014. Crossref
-
Cyran Clemens C, Paprottka Philipp M, Eisenblätter Michel, Clevert Dirk A, Rist Carsten, Nikolaou Konstantin, Lauber Kirsten, Wenz Frederik, Hausmann Daniel, Reiser Maximilian F, Belka Claus, Niyazi Maximilian, Visualization, imaging and new preclinical diagnostics in radiation oncology, Radiation Oncology, 9, 1, 2014. Crossref
-
Deng Zixin, Pang Jianing, Yang Wensha, Yue Yong, Sharif Behzad, Tuli Richard, Li Debiao, Fraass Benedick, Fan Zhaoyang, Four-dimensional MRI using three-dimensional radial sampling with respiratory self-gating to characterize temporal phase-resolved respiratory motion in the abdomen, Magnetic Resonance in Medicine, 75, 4, 2016. Crossref
-
Goldstein Jeffrey D., Lawrence Yaacov R., Appel Sarit, Landau Efrat, Ben-David Merav A., Rabin Tatiana, Benayun Maoz, Dubinski Sergey, Weizman Noam, Alezra Dror, Gnessin Hila, Goldstein Adam M., Baidun Khader, Segel Michael J., Peled Nir, Symon Zvi, Continuous Positive Airway Pressure for Motion Management in Stereotactic Body Radiation Therapy to the Lung: A Controlled Pilot Study, International Journal of Radiation Oncology*Biology*Physics, 93, 2, 2015. Crossref
-
Zachiu C, Papadakis N, Ries M, Moonen C, Denis de Senneville B, An improved optical flow tracking technique for real-time MR-guided beam therapies in moving organs, Physics in Medicine and Biology, 60, 23, 2015. Crossref
-
Kaza E, Symonds-Tayler R, Collins D J, McDonald F, McNair H A, Scurr E, Koh D-M, Leach M O, First MRI application of an active breathing coordinator, Physics in Medicine and Biology, 60, 4, 2015. Crossref
-
Glynne-Jones Rob, Tan David, Hughes Robert, Hoskin Peter, Squamous-cell carcinoma of the anus: progress in radiotherapy treatment, Nature Reviews Clinical Oncology, 13, 7, 2016. Crossref
-
Boda-Heggemann Judit, Knopf Antje-Christin, Simeonova-Chergou Anna, Wertz Hansjörg, Stieler Florian, Jahnke Anika, Jahnke Lennart, Fleckenstein Jens, Vogel Lena, Arns Anna, Blessing Manuel, Wenz Frederik, Lohr Frank, Deep Inspiration Breath Hold—Based Radiation Therapy: A Clinical Review, International Journal of Radiation Oncology*Biology*Physics, 94, 3, 2016. Crossref
-
Kostiukhina Natalia, Georg Dietmar, Rollet Sofia, Kuess Peter, Sipaj Andrej, Andrzejewski Piotr, Furtado Hugo, Rausch Ivo, Lechner Wolfgang, Steiner Elisabeth, Kertész Hunor, Knäusl Barbara, Advanced Radiation DOSimetry phantom (ARDOS): a versatile breathing phantom for 4D radiation therapy and medical imaging, Physics in Medicine & Biology, 62, 20, 2017. Crossref
-
Iwata Hiromitsu, Inoue Mitsuhiro, Shiomi Hiroya, Murai Taro, Tatewaki Koshi, Ohta Seiji, Okawa Kohei, Yokota Naoki, Shibamoto Yuta, Evaluation of Dose Uncertainty to the Target Associated With Real-Time Tracking Intensity-Modulated Radiation Therapy Using the CyberKnife Synchrony System, Technology in Cancer Research & Treatment, 15, 1, 2016. Crossref
-
Aschenbrenner Katharina P., Guthier Christian V., Lyatskaya Yulia, Boda-Heggemann Judit, Wenz Frederik, Hesser Jürgen W., Feasibility of using single photon counting X-ray for lung tumor position estimation based on 4D-CT, Zeitschrift für Medizinische Physik, 27, 3, 2017. Crossref
-
Blessing Manuel, Hofmann Julian, Vogel Lena, Boda-Heggemann Judit, Lohr Frank, Wenz Frederik, Stieler Florian, Simeonova-Chergou Anna, An offline technique to evaluate residual motion of the diaphragm during deep inspiratory breath-hold from cone-beam CT datasets, Strahlentherapie und Onkologie, 194, 9, 2018. Crossref
-
Lafitte L, Zachiu C, Kerkmeijer L G W, Ries M, Denis de Senneville B, Accelerating multi-modal image registration using a supervoxel-based variational framework, Physics in Medicine & Biology, 63, 23, 2018. Crossref
-
Cusumano Davide, Dhont Jennifer, Boldrini Luca, Chiloiro Giuditta, Romano Angela, Votta Claudio, Longo Silvia, Placidi Lorenzo, Azario Luigi, De Spirito Marco, Verellen Dirk, Valentini Vincenzo, Reliability of ITV approach to varying treatment fraction time: a retrospective analysis based on 2D cine MR images, Radiation Oncology, 15, 1, 2020. Crossref
-
Schmitt Daniela, Blanck Oliver, Gauer Tobias, Fix Michael K., Brunner Thomas B., Fleckenstein Jens, Loutfi-Krauss Britta, Manser Peter, Werner Rene, Wilhelm Maria-Lisa, Baus Wolfgang W., Moustakis Christos, Technological quality requirements for stereotactic radiotherapy, Strahlentherapie und Onkologie, 196, 5, 2020. Crossref
-
Wang Lei, Ke Qiao, Huang Qizhen, Shao Lingdong, Chen Juhui, Wu Junxin, Stereotactic body radiotherapy versus radiofrequency ablation for hepatocellular carcinoma: a systematic review and meta-analysis, International Journal of Hyperthermia, 37, 1, 2020. Crossref
-
Allison Ron R, The electromagnetic spectrum: current and future applications in oncology, Future Oncology, 9, 5, 2013. Crossref
-
Vogel Lena, Sihono Dwi Seno Kuncoro, Weiss Christel, Lohr Frank, Stieler Florian, Wertz Hansjörg, von Swietochowski Sandra, Simeonova-Chergou Anna, Wenz Frederik, Blessing Manuel, Boda-Heggemann Judit, Intra-breath-hold residual motion of image-guided DIBH liver-SBRT: An estimation by ultrasound-based monitoring correlated with diaphragm position in CBCT, Radiotherapy and Oncology, 129, 3, 2018. Crossref
-
Cheng Xinyi, Yang Dongxu, Zhong Yuncheng, Shao Yiping, Real-time marker-less tumor tracking with TOF PET: in silico feasibility study, Physics in Medicine & Biology, 67, 11, 2022. Crossref
-
Méndez Romero Alejandra, Brunner Thomas B., Kirichenko Alexander V., Tomé Wolfgang A., Liang Yun, Ogden Nathan, Heijmen Ben J. M., Alternate Fractionation for Hepatic Tumors, in Alternate Fractionation in Radiotherapy, 2017. Crossref
-
Kaestner Lena, Abo-Madyan Yasser, Huber Lena, Spaniol Manon, Siebenlist Kerstin, Sacks Marie-Kristin, Ehmann Michael, Stieler Florian, Clausen Sven, Lohr Frank, Fleckenstein Jens, Boda-Heggemann Judit, Motion Management in a Patient With Tracheostomy During Lung Stereotactic Body Radiation Therapy: Breath Hold Is Worth a Try, Advances in Radiation Oncology, 7, 3, 2022. Crossref
-
Lafitte L., Giraud R., Zachiu C., Ries M., Sutter O., Petit A., Seror O., Poignard C., de Senneville B. Denis, Patch-based field-of-view matching in multi-modal images for electroporation-based ablations, Computerized Medical Imaging and Graphics, 84, 2020. Crossref