每年出版 4 期
ISSN 打印: 0893-9675
ISSN 在线: 2162-6448
Indexed in
Strategies to Strike Survival Networks in Cancer
摘要
The machinery that maintains cellular and tissue homeostasis in a healthy individual is recruited and hijacked by cancer cells to support tumor growth and progression. Activation of often unpredictable alternative or complementary signaling pathways allows cancer cells to bypass the intrinsic self-destructive machinery and the limited replicative potential present in every cell for correct homeostasis maintenance. Therefore, evasion/resistance to apoptosis/cell death, self-sufficiency in growth/survival signals, and limitless replicative potential remain undoubted hallmarks of cancer, contributing to drug resistance. Herein, we specifically review antitumor strategies involving agents targeting deregulated receptor tyrosine kinases, selected epigenetic modifications, the ubiquitin-proteasome system, the unfolded protein response, the apoptotic pathway, and peculiar nucleic acid structures, with the aim of highlighting the mechanisms underlying favorable drug interaction. In this context, we focus on preclinical studies that have already been translated into clinical investigation. Particular emphasis is devoted to strategies effective in solid tumors because of the peculiarity and distinctive features of solid tumors in terms of drug delivery and relative to the impact of the tumor microenvironment.
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Corno Cristina, Gatti Laura, Arrighetti Noemi, Carenini Nives, Zaffaroni Nadia, Lanzi Cinzia, Perego Paola, Axl molecular targeting counteracts aggressiveness but not platinum-resistance of ovarian carcinoma cells, Biochemical Pharmacology, 136, 2017. Crossref
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Beretta Giovanni Luca, Cassinelli Giuliana, Pennati Marzia, Zuco Valentina, Gatti Laura, Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents, European Journal of Medicinal Chemistry, 142, 2017. Crossref
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Cassinelli Giuliana, Dal Bo Laura, Favini Enrica, Cominetti Denis, Pozzi Sabina, Tortoreto Monica, De Cesare Michelandrea, Lecis Daniele, Scanziani Eugenio, Minoli Lucia, Naggi Annamaria, Vlodavsky Israel, Zaffaroni Nadia, Lanzi Cinzia, Supersulfated low-molecular weight heparin synergizes with IGF1R/IR inhibitor to suppress synovial sarcoma growth and metastases, Cancer Letters, 415, 2018. Crossref
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Argyle David J., Khanna Chand, Giancristofaro Nicole, Tumor Biology and Metastasis, in Withrow and MacEwen's Small Animal Clinical Oncology, 2020. Crossref
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Lanzi Cinzia, Cassinelli Giuliana, Receptor tyrosine kinases and heparan sulfate proteoglycans: Interplay providing anticancer targeting strategies and new therapeutic opportunities, Biochemical Pharmacology, 178, 2020. Crossref