图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
医药载体系统评论综述
影响因子: 2.9 5年影响因子: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN 打印: 0743-4863
ISSN 在线: 2162-660X

医药载体系统评论综述

DOI: 10.1615/CritRevTherDrugCarrierSyst.v18.i5.20
43 pages

Multifunctional Matrices for Oral Peptide Delivery

Andreas Bernkop-Schnurch
Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Althanstr. 14, A-1090 Vienna, Austria
Greg Walker
Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Althanstr. 14, A-1090 Vienna, Austria

ABSTRACT

The oral administration of peptide drugs represents one of the greatest challenges in pharmaceutical technology. To gain a sufficient bioavailability of these therapeutic agents, various barriers including the mucus-layer barrier, the enzymatic barrier, and the membrane barrier have to be overcome. A promising strategy for achieving this goal is the use of multifunctional matrices. These matrices are based on polymers that display mucoadhesive properties, a permeation-enhancing effect, enzyme-inhibiting properties, and/or a high buffer capacity. Moreover, a sustained or delayed drug release can be provided by delivery systems that contain such polymers. Among them, polyacrylates, cellulose derivatives, and chitosan are promising excipients that can also be customized by chemical modification to improve certain properties.For example, the covalent attachment of thiol moieties on these polymers leads to improved mucoadhesive and permeation-enhancing properties, and the conjugation of enzyme inhibitors enables the matrices to provide protection for peptide drugs against enzymatic degradation. The efficacy of multifunctional matrices in oral peptide delivery has been verified by various in vivo studies that could pave the way for the development of commercially viable formulations.


Articles with similar content:

Lipid-Based Cochleates: A Promising Formulation Platform for Oral and Parenteral Delivery of Therapeutic Agents
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.24, 2007, issue 1
Emilio Squillante, III, Kwon H. Kim, Ravi Rao
Nano-Aggregates: Emerging Delivery Tools for Tumor Therapy
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.30, 2013, issue 6
Vinod Kumar Sharma, Ankit Jain, Vandana Soni
Amorphous Drug Delivery Systems: Molecular Aspects, Design, and Performance
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.21, 2004, issue 3
Piyush Gupta, Aditya Mohan Kaushal, Arvind Kumar Bansal
Ligand-Appended BBB-Targeted Nanocarriers (LABTNs)
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.32, 2015, issue 2
Ankit Jain, Sanjay Kumar Jain
Pharmaceutical and Biomedical Potential of Surface Engineered Dendrimers
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.24, 2007, issue 3
Narendra Kumar Jain, Umesh Gupta, Jitendra Satija