每年出版 6 期
ISSN 打印: 0743-4863
ISSN 在线: 2162-660X
Indexed in
Immunoisolation Cell Therapy for CNS Diseases
摘要
Delivery of potentially therapeutic drugs to the brain is hindered by the blood-brain barrier (BBB), which restricts the diffusion of drugs from the vasculature to the brain parenchyma. One means of overcoming the BBB is with cellular implants that produce and deliver therapeutic molecules directly into the CNS region of interest. In this paper we describe the current status of one iteration of cell-based therapy that uses xenogeneic cells encased within a selectively permeable polymeric membrane; this is known as immunoisolation. For the purposes of this review, cell immunoisolation for treating CNS diseases is presented in terms of device configurations, membrane manufacturing, characterization in relevant preclinical model systems, and the current status of clinical trials.
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Zhan Min Jing, Li Gang, Wei Qiang, Cui Hua Lei, Lin Ling, Bioactivity of TiO<sub>2</sub>/Ti Composite Membrane with Different Crystral Phase, Advanced Materials Research, 287-290, 2011. Crossref