图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
医药载体系统评论综述
影响因子: 2.9 5年影响因子: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN 打印: 0743-4863
ISSN 在线: 2162-660X

医药载体系统评论综述

DOI: 10.1615/CritRevTherDrugCarrierSyst.2016015273
pages 159-193

PLGA Nanoparticles and Their Versatile Role in Anticancer Drug Delivery

Iliyas Khan
Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan India 305817
Avinash Gothwal
Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan India 305817
Ashok Kumar Sharma
Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan India 305817
Prashant Kesharwani
Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour Central University, Sagar (MP) 470003, India; Pharmaceutics and Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, 226031, U.P., India
Lokesh Gupta
Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan India 305817
Arun K. Iyer
Use-Inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan
Umesh Gupta
Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan India 305817

ABSTRACT

Nanotechnological advancement has become a key standard for the diagnosis and treatment of several complex disorders such as cancer by utilizing the enhanced permeability and retention effect and tumor-specific targeting. Synthesis and designing the formulation of active agents in terms of their efficient delivery is of prime importance for healthcare. The use of nanocarriers has resolved the undesirable characteristics of anticancer drugs such as low solubility and poor permeability in cells. Several types of nanoparticles (NPs) have been designed with the use of various polymers along or devoid of surface engineering for targeting tumor cells. All NPs include polymers in their framework and, of these, polylactide-co-glycolide (PLGA) is biodegradable and Food and Drug Administration approved for human use. PLGA has been used extensively in the development of NPs for anticancer drug delivery. The extensive use of PLGA NPs is promising for cancer therapy, with higher efficiency and less adverse effects. The present review focused on recent developments regarding PLGA NPs, the methods used for their preparation, their characterization, and their utility in the delivery of chemotherapeutic agents.


Articles with similar content:

Nanostructured Materials in Drug and Gene Delivery: A Review of the State of the Art
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 2
Krutika Sawant, Kailash C. Petkar, Sandip S. Chavhan, Snezana Agatonovik-Kustrin
Recent Advances in Nanoparticle-Based Targeted Drug-Delivery Systems Against Cancer and Role of Tumor Microenvironment
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.34, 2017, issue 4
Usman Ali Ashfaq, Muhammad Zubair Yousaf, Erum Yasmeen, Muhammad Riaz
Liposome-Based Nanomedicine Therapeutics for Rheumatoid Arthritis
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.34, 2017, issue 4
Richard T. Addo, Vikas Kumar, Ruhi Ubale, Firoz Anwar, Mahfoozur Rahman, Sarwar Beg, Sohail Akhter, Raisuddin Ali
Progress in Lipid-Based Nanoparticles for Cancer Therapy
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 3-4
Eliahu Heldman, Charles Linder, Sarina Grinberg
Role of Block Copolymer Nanoconstructs in Cancer Therapy
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 2
H. G. Agrawal, K. K. Upadhyay, C. Schatz, Sebastian Lecommandoux, J. F. Le Meins, Ambikanandan Misra, C. Upadhyay