图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
医药载体系统评论综述
影响因子: 2.9 5年影响因子: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN 打印: 0743-4863
ISSN 在线: 2162-660X

医药载体系统评论综述

DOI: 10.1615/CritRevTherDrugCarrierSyst.2013005964
pages 217-256

Drug Carrier Systems for Solubility Enhancement of BCS Class II Drugs: A Critical Review

Sumit Kumar
Nanomedicine Research Lab, Department of Pharmaceutics, ISF College of Pharmacy, Moga
Deepak Bhargava
Department of Quality Assurance, ISF College of Pharmacy, Moga
Arti Thakkar
Department of Quality Assurance, ISF College of Pharmacy, Moga
Saahil Arora
Department of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab), India 09501223252(M)

ABSTRACT

Poor aqueous solubility impedes a drug's bioavailability and challenges its pharmaceutical development. Pharmaceutical development of drugs with poor water solubility requires the establishment of a suitable formulation layout among various techniques. Various approaches have been investigated extensively to improve the aqueous solubility and poor dissolution rate of BCS class II and IV drugs. In this literature review, novel formulation options, particularly for class II drugs designed for applications such as micronization, self-emulsification, cyclodextrin complexation, co-crystallisation, super critical fluid technology, solubilisation by change in pH, salt formation, co-solvents, melt granulation, and solid dispersion, liposomal/niosomal formulations, are discussed in detail to introduce biopharmaceutical challenges and recent approaches to facilitate more efficient drug formulation and development.


Articles with similar content:

Progress in Lipid-Based Nanoparticles for Cancer Therapy
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 3-4
Eliahu Heldman, Charles Linder, Sarina Grinberg
Functional Polymeric Nanoparticles: An Efficient and Promising Tool for Active Delivery of Bioactives
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.23, 2006, issue 4
Senthilkumar Murugesan, Tathagata Dutta, Abhay Asthana, Manoj Tare, Surbhi Saraf, Narendra Kumar Jain, Vijayaraj Rajkumar, Manoj Nahar, Dinesh Mishra
Liposomes a Vesicular Nanocarrier: Potential Advancements in Cancer Chemotherapy
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.29, 2012, issue 5
Pramod Kumar, Arvind Gulbake, Sanjay Kumar Jain
In Situ Gel-Forming System: An Attractive Alternative for Nasal Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.30, 2013, issue 5
Yanhua Jia, Jianli Ma, Xiaoqing Wang, Lei Gao, Xiang Li, Guiyang Liu, Qingzhe Zhang, Shaolai Guo
Lipid Materials for Topical and Transdermal Delivery of Nanoemulsions
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.31, 2014, issue 5
R. Jayachandra Babu, Kasturi R. Pawar