图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
医药载体系统评论综述
影响因子: 2.9 5年影响因子: 3.72 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN 打印: 0743-4863
ISSN 在线: 2162-660X

医药载体系统评论综述

DOI: 10.1615/CritRevTherDrugCarrierSyst.v28.i1.20
pages 47-99

Gastroretentive Floating Drug-Delivery Systems: A Critical Review

Udaya Kotreka
Boehringer Ingelheim Roxane Lboratories, Inc
Moji Christianah Adeyeye
Department of Biopharmaceutical Sciences College of Pharmacy, Roosevelt University, Schaumburg, IL, USA

ABSTRACT

The oral delivery of drugs with a narrow absorption window in the gastrointestinal tract (GIT) is often limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the site of absorption. To overcome this drawback and to maximize the oral absorption of these drugs, gastroretentive systems such as mucoadhesive, high-density, expandable, and floating systems have been developed. These systems provide controlled delivery of drugs with prolonged gastric residence time. However, in humans, differences in various physiological and biological factors can affect the gastric residence time and drug-delivery behavior from gastroretentive systems. Some floating drugdelivery systems (FDDS) have shown the capability to accommodate these variations without affecting drug release. This review mainly focuses on various physiological considerations for development of FDDS, and highlights recent technological developments including new dosage forms and their production techniques (e.g., holt-melt extrusion, melt pelletization, and pulsed plasma-irradiation processes). Alternatives to the existing in vitro compendial methods for evaluating floating dosage forms will be discussed, and a critical analysis of the existing literature on FDDS, identifying the potential areas for future research, is provided.


Articles with similar content:

Gastroretentive Drug Delivery Systems for Therapeutic Management of Peptic Ulcer
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.31, 2014, issue 6
Animesh Kumar, Goutam Rath, Tarun Garg, Amit Kumar Goyal
Gastric Retentive Dosage Forms: A Review
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.20, 2003, issue 6
Verne E. Cowles, Bret Berner, Sui Yuen Eddie Hou
Floating Dosage Systems in Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.19, 2002, issue 6
L. Hari Vardhan Reddy, R. S. R. Murthy
Lipid Nanoparticles for Nasal/Intranasal Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.34, 2017, issue 3
S. Cunha, M. H. Amaral, J. M. Sousa Lobo, Ana C. Silva
Potential Approaches for Drug Delivery to the Brain: Past, Present, and Future
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.27, 2010, issue 3
Vandana Soni, Piush Khare, Anekant Jain, Arvind Gulbake, Sanjay Kumar Jain