每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
Immune Functions of Proteinase 3
摘要
The primary function of neutrophil-derived serine proteases, neutrophil elastase, cathepsin G, and proteinase 3 (PR3) are thought to be the degradation of extracellular proteins at sites of inflammation, but excessive, prolonged, or inappropriate proteolytic activity causes harmful effects in the body. Although there are strong structural similarities among these proteases, PR3 has unique properties in many respects. In particular, PR3 is a major target antigen of autoantibodies, anti-neutrophil cytoplasmic antibodies (ANCA). Recent findings also revealed that PR3 is critically involved in the regulation of immune function. This review discusses the expression of PR3 in nonhemopoietic cells and focuses on the immune functions of PR3 with respect to direct modulation of cell signaling by PR3, PR3-mediated cell activation, and the possible involvement of protease-activated receptors, modulation of the cytokine network, innate immunity and PR3, and recent findings about the generation and function of ANCA.
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Korkmaz Brice, Attucci Sylvie, Juliano Maria Aparecida, Kalupov Timofey, Jourdan Marie-Lise, Juliano Luiz, Gauthier Francis, Measuring elastase, proteinase 3 and cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates, Nature Protocols, 3, 6, 2008. Crossref
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Choi Ji-Da, Bae Su-Young, Hong Jae-Woo, Azam Tania, Dinarello Charles A., Her Erk, Choi Whan-Soo, Kim Bo-Kyung, Lee Chang-Kwon, Yoon Do-Young, Kim Sun-Jong, Kim Soo-Hyun, Identification of the most active interleukin-32 isoform, Immunology, 126, 4, 2009. Crossref
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Joosten Leo A. B., Netea Mihai G., Fantuzzi Giamila, Koenders Marije I., Helsen Monique M. A., Sparrer Helmut, Pham Christine T., van der Meer Jos W. M., Dinarello Charles A., van den Berg Wim B., Inflammatory arthritis in caspase 1 geneâdeficient mice: Contribution of proteinase 3 to caspase 1âindependent production of bioactive interleukin-1β, Arthritis & Rheumatism, 60, 12, 2009. Crossref
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Pederzoli-Ribeil Magali, Maione Francesco, Cooper Dianne, Al-Kashi Adam, Dalli Jesmond, Perretti Mauro, D'Acquisto Fulvio, Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature, Blood, 116, 20, 2010. Crossref
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Korkmaz Brice, Moreau Thierry, Gauthier Francis, Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions, Biochimie, 90, 2, 2008. Crossref
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Wittmann Miriam, Kingsbury Sarah R., McDermott Michael F., Is caspase 1 central to activation of interleukin-1?, Joint Bone Spine, 78, 4, 2011. Crossref
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Hong Jaewoo, Bae Suyoung, Kang Youngsun, Yoon Doyoung, Bai Xiyuan, Chan Edward D., Azam Tania, Dinarello Charles A., Lee Siyoung, Her Erk, Rho Gyujin, Kim Soohyun, Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFα and IL-1β, Cytokine, 49, 2, 2010. Crossref
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Gabelloni María Laura, Sabbione Florencia, Jancic Carolina, Bass Juan Fuxman, Keitelman Irene, Iula Leonardo, Oleastro Matías, Geffner Jorge R., Trevani Analía S., NADPH oxidase derived reactive oxygen species are involved in human neutrophil IL-1β secretion but not in inflammasome activation, European Journal of Immunology, 43, 12, 2013. Crossref
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Nishioka Takashi, Kuroishi Toshinobu, Sugawara Yumiko, Yu Zhiqian, Sasano Takashi, Endo Yasuo, Sugawara Shunji, Induction of serum IL-18 withPropionibacterium acnesand lipopolysaccharide in phagocytic macrophage-inactivated mice, Journal of Leukocyte Biology, 82, 2, 2007. Crossref
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Jégot Gwenhael, Derache Chrystelle, Castella Sandrine, Lahouassa Hichem, Pitois Elodie, Jourdan Marie Lise, Remold‐O'Donnell Eileen, Kellenberger Christine, Gauthier Francis, Korkmaz Brice, A substrate‐based approach to convert SerpinB1 into a specific inhibitor of proteinase 3, the Wegener's granulomatosis autoantigen, The FASEB Journal, 25, 9, 2011. Crossref
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Horwitz Marshall S., Duan Zhijun, Korkmaz Brice, Lee Hu-Hui, Mealiffe Matthew E., Salipante Stephen J., Neutrophil elastase in cyclic and severe congenital neutropenia, Blood, 109, 5, 2007. Crossref
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Korkmaz Brice, Hajjar Eric, Kalupov Timofey, Reuter Nathalie, Brillard-Bourdet Michèle, Moreau Thierry, Juliano Luiz, Gauthier Francis, Influence of Charge Distribution at the Active Site Surface on the Substrate Specificity of Human Neutrophil Protease 3 and Elastase, Journal of Biological Chemistry, 282, 3, 2007. Crossref
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Morales-Primo Abraham U., Becker Ingeborg, Zamora-Chimal Jaime, Neutrophil extracellular trap-associated molecules: a review on their immunophysiological and inflammatory roles, International Reviews of Immunology, 41, 2, 2022. Crossref
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Komine Ken-ichi, Kuroishi Toshinobu, Ozawa Akiko, Komine Yumiko, Minami Takumi, Shimauchi Hidetoshi, Sugawara Shunji, Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients, Molecular Immunology, 44, 7, 2007. Crossref