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ISSN 打印: 1040-8401

ISSN 在线: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Opioid and Opiate Immunoregulatory Processes

卷 16, 册 2, 1996, pp. 109-144
DOI: 10.1615/CritRevImmunol.v16.i2.10
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摘要

The discovery of the ability of the nervous system to communicate through "public" circuits with other systems of the body is attributed to Ernst and Berta Scharrer, who described the neurosecretory process in 1928. Indeed, the immune system has been identified as another important neuroendocrine target tissue. Opioid peptides are involved in this communication (i.e., neuroimmune) and with that of autoimmunoregulation (communication between immunocytes). The significance of opioid neuropeptide involvement with the immune system is ascertained from the presence of novel δ, μ., and κ receptors on inflammatory cells that result in modulation of cellular activity after activation, as well as the presence of specific enzymatic degradation and regulation processes. In contrast to the relatively uniform antinociceptive action of opiate and opioid signal molecules in neural tissues, the presence of naturally occurring morphine in plasma and a novel μ3 opiate-specific receptor on inflammatory cells adds to the growing knowledge that opioid and opiate signal molecules may have antagonistic actions in select tissues. In examining various disorders (e.g., human immunodeficiency virus, substance abuse, parasitism, and the diffuse inflammatory response associated with surgery) evidence has also been found for the involvement of opiate/opioid signaling in prominent mechanisms. In addition, the presence of similar mechanisms in man and organisms 500 million years divergent in evolution bespeaks the importance of this family of signal molecules. The present review provides an overview of recent advances in the field of opiate and opioid immunoregulatory processes and speculates as to their significance in diverse biological systems.

对本文的引用
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  116. Fimiani C, Arcuri E, Santoni A, Rialas C.M, Bilfinger T.V, Peter D, Salzet B, Stefano G.B, μ3 Opiate receptor expression in lung and lung carcinoma: ligand binding and coupling to nitric oxide release, Cancer Letters, 146, 1, 1999. Crossref

  117. Salzet Michel, Verger-Bocquet Martine, Elements of angiotensin system are involved in leeches and mollusks immune response modulation, Molecular Brain Research, 94, 1-2, 2001. Crossref

  118. Davis Randall L., Buck Daniel J., Saffarian Neda, Stevens Craig W., The opioid antagonist, β-funaltrexamine, inhibits chemokine expression in human astroglial cells, Journal of Neuroimmunology, 186, 1-2, 2007. Crossref

  119. Stefano George B., Kream Richard M., Mantione Kirk J., Sheehan Melinda, Cadet Patrick, Zhu Wei, Bilfinger Thomas V., Esch Tobias, Endogenous morphine/nitric oxide-coupled regulation of cellular physiology and gene expression: Implications for cancer biology, Seminars in Cancer Biology, 18, 3, 2008. Crossref

  120. Salzet M., Stefano G.B., The endocannabinoid system in invertebrates, Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 66, 2-3, 2002. Crossref

  121. Welters I.D., Menzebach A., Goumon Y., Langefeld T.W., Teschemacher H., Hempelmann G., Stefano G.B., Morphine suppresses complement receptor expression, phagocytosis, and respiratory burst in neutrophils by a nitric oxide and μ3 opiate receptor-dependent mechanism, Journal of Neuroimmunology, 111, 1-2, 2000. Crossref

  122. Balog T., Marotti T., Abramić M., Beusan-Svoboda I., Sobočanec S., Hršak I., Neutrophil neutral endopeptidase variation and its regulation by opioid peptides, International Immunopharmacology, 1, 3, 2001. Crossref

  123. Schneemilch Christine E, Schilling Thomas, Bank Ute, Effects of general anaesthesia on inflammation, Best Practice & Research Clinical Anaesthesiology, 18, 3, 2004. Crossref

  124. Salzet Michel, The neuroendocrine system of annelids, Canadian Journal of Zoology, 79, 2, 2001. Crossref

  125. Cucumel K, Bagnol D, Moinier D, Fischer J, Conrath M, Cupo A, The rat dermorphin-like immunoreactivity is supported by an aminopeptidase resistant peptide, Journal of Neuroimmunology, 81, 1-2, 1998. Crossref

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  127. Mola Lucrezia, Bertacchi Ilaria, Gambarelli Andrea, Pederzoli Aurora, Occurrence of ACTH- and enkephalin-like peptides in the developing gut of Dicentrarchus labrax L., General and Comparative Endocrinology, 136, 1, 2004. Crossref

  128. Cadet Patrick, Stefano George B, Mytilus edulis pedal ganglia express μ opiate receptor transcripts exhibiting high sequence identity with human neuronal μ1, Molecular Brain Research, 74, 1-2, 1999. Crossref

  129. Tian Mingting, Broxmeyer Hal E., Fan Yi, Lai Zhennan, Zhang Shengwen, Aronica Susan, Cooper Scott, Bigsby Robert M., Steinmetz Rosemary, Engle Sandra J., Mestek Anton, Pollock Jonathan D., Lehman Michael N., Jansen Heiko T., Ying Moyin, Stambrook Peter J., Tischfield Jay A., Yu Lei, Altered Hematopoiesis, Behavior, and Sexual Function in μ Opioid Receptor–deficient Mice, Journal of Experimental Medicine, 185, 8, 1997. Crossref

  130. Cadet Patrick, Bilfinger Thomas V., Fimiani Caterina, Peter Doris, Stefano George B., Human Vascular and Cardiac Endothelia Express Mu Opiate Receptor Transcripts, Endothelium, 7, 3, 2000. Crossref

  131. Pederzoli Aurora, Mola Lucrezia, The early stress responses in fish larvae, Acta Histochemica, 118, 4, 2016. Crossref

  132. Pilakka-Kanthikeel Sudheesh, Atluri Venkata Subba Rao, Sagar Vidya, Saxena Shailendra K., Nair Madhavan, Buch Shilpa J., Targeted Brain Derived Neurotropic Factors (BDNF) Delivery across the Blood-Brain Barrier for Neuro-Protection Using Magnetic Nano Carriers: An In-Vitro Study, PLoS ONE, 8, 4, 2013. Crossref

  133. Liu Dong-wu, Chen Zhi-wei, Xu Hong-zhi, Effects of Leucine-enkephalin on Catalase Activity and Hydrogen Peroxide Levels in the Haemolymph of the Pacific Oyster (Crassostrea gigas), Molecules, 13, 4, 2008. Crossref

  134. Stefano George B., Salzet Beatrice, Salzet Michel, Identification and characterization of the leech CNS cannabinoid receptor: coupling to nitric oxide release, Brain Research, 753, 2, 1997. Crossref

  135. Zhu W., Baggerman G., Secor W. Evan, Casares F., Pryor S. C., Fricchione G. L., Ruiz-Tiben E., Eberhard M. L., Bimi L., Stefano G. B., Dracunculus medinensisandSchistosoma mansonicontain opiate alkaloids, Annals of Tropical Medicine & Parasitology, 96, 3, 2002. Crossref

  136. Preter Maurice, Lifelong Opioidergic Vulnerability Through Early Life Separation: A Recent Extension of the False Suffocation Alarm Theory of Panic Disorder, in Panic Disorder, 2016. Crossref

  137. Bakr Mohamed A.-E.-M., Amr Samy A.-E. R., Mohamed Sahar A., Hamed Hosny B., Abd EL-Rahman Ahmad M., Mostafa Mohamed A. M., El Sherif Fatma A., Comparison Between the Effects of Intravenous Morphine, Tramadol, and Ketorolac on Stress and Immune Responses in Patients Undergoing Modified Radical Mastectomy, The Clinical Journal of Pain, 32, 10, 2016. Crossref

  138. Wilkins Matthew, Park Gilbert R., The peripheral effects of opioids, Current Opinion in Critical Care, 5, 4, 1999. Crossref

  139. Stanojević Stanislava, Dimitrijević Mirjana, Kovačević-Jovanović Vesna, Miletić Tatjana, Vujić Vesna, Radulović Jelena, Stress Applied During Primary Immunization Affects the Secondary Humoral Immune Response in the Rat: Involvement of Opioid Peptides, Stress, 6, 4, 2003. Crossref

  140. Zhu W., Mantione K.J., Kream R.M., Cadet P., Stefano G.B., Cholinergic Regulation of Morphine Release from Human White Blood Cells: Evidence for a Novel Nicotinic Receptor via Pharmacological and Micro Array Analysis, International Journal of Immunopathology and Pharmacology, 20, 2, 2007. Crossref

  141. Fimiani Caterina, Mattocks Dwight, Cavani Francesco, Salzet Michel, Deutsch Dale G., Pryor Stephen, Bilfinger Thomas V., Stefano George B., Morphine and Anandamide Stimulate Intracellular Calcium Transients in Human Arterial Endothelial Cells: Coupling to Nitric Oxide Release1Abbreviations: NO–Nitric oxide, cNOS–constitutive nitric oxide synthase.1, Cellular Signalling, 11, 3, 1999. Crossref

  142. Stefano George B., Salzet Michel, Magazine Harold I., Bilfinger Thomas V., Antagonism of LPS and IFN-γ Induction of iNOS in Human Saphenous Vein Endothelium by Morphine and Anandamide by Nitric Oxide Inhibition of Adenylate Cyclase, Journal of Cardiovascular Pharmacology, 31, 6, 1998. Crossref

  143. Galligan James J., Sternini Catia, Insights into the Role of Opioid Receptors in the GI Tract: Experimental Evidence and Therapeutic Relevance, in Gastrointestinal Pharmacology, 239, 2016. Crossref

  144. Siong Chan Daniel Chu, Cao Thong Huy, Ng Leong Loke, Proenkephalin in Heart Failure, Heart Failure Clinics, 14, 1, 2018. Crossref

  145. Ma K., Ma P., Lu H., Liu S., Cao Q., Fentanyl Suppresses the Survival of CD4+T Cells Isolated from Human Umbilical Cord Blood through Inhibition of IKKs-mediated NF-κB Activation, Scandinavian Journal of Immunology, 85, 5, 2017. Crossref

  146. Stefano George B., Salzet Michel, Bilfinger Thomas V., Long-Term Exposure of Human Blood Vessels to HIV gp120, Morphine, and Anandamide Increases Endothelial Adhesion of Monocytes: Uncoupling of Nitric Oxide Release, Journal of Cardiovascular Pharmacology, 31, 6, 1998. Crossref

  147. Stefano George B., Christensen V. Brix, Tonnesen Else, Liu Yu, Hughes Thomas K., Bilfinger Thomas V., Interleukin-10 Stimulation of Endogenous Nitric Oxide Release from Human Saphenous Veins Diminishes Immunocyte Adherence, Journal of Cardiovascular Pharmacology, 30, 1, 1997. Crossref

  148. Sayed Jehan Ahmed, Elshafy Sayed Kaoud Abd, Kamel Emad Zareif, Riad Mohamed Amir Fathy, Mahmoud Amal Ahmed, Khalaf Ghada Shalaby, The impact of caudally administrated tramadol on immune response and analgesic efficacy for pediatric patients: a comparative randomized clinical trial, The Korean Journal of Pain, 31, 3, 2018. Crossref

  149. Cıcek Erdinc, Demırel Başak, Cıcek Ismet Esra, Kıraç Aslı Seda, Eren Ibrahim, Increased Neutrophil-lymphocyte and Platelet-lymphocyte Ratios in Male Heroin Addicts: A Prospective Controlled Study, Clinical Psychopharmacology and Neuroscience, 16, 2, 2018. Crossref

  150. Kasckow John, Geracioti Thomas D., Neuroregulatory Peptides of Central Nervous System Origin, in Hormones, Brain and Behavior, 2002. Crossref

  151. Labit Elodie, Rabiller Lise, Rampon Christine, Guissard Christophe, André Mireille, Barreau Corinne, Cousin Béatrice, Carrière Audrey, Eddine Mohamad Ala, Pipy Bernard, Pénicaud Luc, Lorsignol Anne, Vriz Sophie, Dromard Cécile, Casteilla Louis, Opioids prevent regeneration in adult mammals through inhibition of ROS production, Scientific Reports, 8, 1, 2018. Crossref

  152. Cechova Kristina, Hlouskova Martina, Javorkova Eliska, Roubalova Lenka, Ujcikova Hana, Holan Vladimir, Svoboda Petr, Up-regulation of μ-, δ- and κ-opioid receptors in concanavalin A-stimulated rat spleen lymphocytes, Journal of Neuroimmunology, 321, 2018. Crossref

  153. Liu Ziqiang, Liu Yao, Gu Yaqi, Gao Lili, Li Ao, Liu Dongwu, Kang Cuijie, Pang Qiuxiang, Wang Xiaoqian, Han Qiang, Yu Hairui, Met-enkephalin inhibits ROS production through Wnt/β-catenin signaling in the ZF4 cells of zebrafish, Fish & Shellfish Immunology, 88, 2019. Crossref

  154. Salzet Michel, Vieau Didier, Breton Christophe, Evidence for an Annelid Neuroendocrine System, in Cell Signalling in Prokaryotes and Lower Metazoa, 2004. Crossref

  155. Stefano George B., Cadet Patrick, Breton Christophe, Goumon Yannick, Prevot Vincent, Dessaint Jean Paul, Beauvillain Jean-Claude, Roumier Ann S., Welters Ingeborg, Salzet Michel, Estradiol-stimulated nitric oxide release in human granulocytes is dependent on intracellular calcium transients: evidence of a cell surface estrogen receptor, Blood, 95, 12, 2000. Crossref

  156. Stefano George B., Cadet Patrick, Breton Christophe, Goumon Yannick, Prevot Vincent, Dessaint Jean Paul, Beauvillain Jean-Claude, Roumier Ann S., Welters Ingeborg, Salzet Michel, Estradiol-stimulated nitric oxide release in human granulocytes is dependent on intracellular calcium transients: evidence of a cell surface estrogen receptor, Blood, 95, 12, 2000. Crossref

  157. Kummer C., Netto E. S., Marshall J. C., The Immunomodulatory Effects of Anesthetic and Analgesic Agents, in Intensive Care Medicine, 2002. Crossref

  158. Mahajan Supriya D., Schwartz Stanley A., Shanahan Thomas C., Chawda Ram P., Nair Madhavan P. N., Morphine Regulates Gene Expression of α- and β-Chemokines and Their Receptors on Astroglial Cells Via the Opioid μ Receptor, The Journal of Immunology, 169, 7, 2002. Crossref

  159. Zhu Wei, Cadet Patrick, Baggerman Geert, Mantione Kirk J., Stefano George B., Human White Blood Cells Synthesize Morphine: CYP2D6 Modulation, The Journal of Immunology, 175, 11, 2005. Crossref

  160. Wang Xu, Liu Jinbiao, Zhou Lina, Ho Wen-Zhe, Morphine Withdrawal Enhances HIV Infection of Macrophages, Frontiers in Immunology, 10, 2019. Crossref

  161. Newman Chris, Buesching Christina D., Detecting the Smell of Disease and Injury: Scoping Evolutionary and Ecological Implications, in Chemical Signals in Vertebrates 14, 2019. Crossref

  162. Makman M. H., Dobrenis K., Surratt C. K., Properties of µ3 Opiate Alkaloid Receptors in Macrophages, Astrocytes, and HL-60 Human Promyelocytic Leukemia Cells, in Drugs of Abuse, Immunomodulation, and Aids, 437, 1998. Crossref

  163. Cadet Patrick, Mantione Kirk J., Stefano George B., Molecular Identification and Functional Expression of μ3, a Novel Alternatively Spliced Variant of the Human μ Opiate Receptor Gene, The Journal of Immunology, 170, 10, 2003. Crossref

  164. Pintar J. E., Kieffer B. L., Genetic Analysis of the Endogenous Opioid System, in Transgenic Models in Pharmacology, 159, 2004. Crossref

  165. Khabbazi Samira, Hassanshahi Mohammadhossein, Hassanshahi Alireza, Peymanfar Yaser, Su Yu-Wen, Xian Cory J., Opioids and matrix metalloproteinases: the influence of morphine on MMP-9 production and cancer progression, Naunyn-Schmiedeberg's Archives of Pharmacology, 392, 2, 2019. Crossref

  166. Restini Carolina Baraldi Araujo, Gonçalves Leticia, Nitric Oxide and Related Aspects Underlying Angina, The Open Cardiovascular Medicine Journal, 11, 1, 2017. Crossref

  167. Zhu Wei, Pryor Stephen C., Putnam Jennifer, Cadet Patrick, Stefano George B., OPIATE ALKALOIDS AND NITRIC OXIDE PRODUCTION IN THE NEMATODE ASCARIS SUUM, Journal of Parasitology, 90, 1, 2004. Crossref

  168. Cadet Patrick, Mantione Kirk J., Zhu Wei, Kream Richard M., Sheehan Melinda, Stefano George B., A Functionally Coupled μ3-Like Opiate Receptor/Nitric Oxide Regulatory Pathway in Human Multi-Lineage Progenitor Cells, The Journal of Immunology, 179, 9, 2007. Crossref

  169. Zingali Russolina B., Nogueira Ana Cristina Ferraz, Bothrojaracin – A Potent Thrombin Inhibitor, in Toxins and Hemostasis, 2010. Crossref

  170. Stefano George B., Salzet Michel, Ottaviani Enzo, Neuroimmune Chemical Messengers and Their Conservation During Evolution, in Stem Cells in Marine Organisms, 2009. Crossref

  171. Kummer C., Netto F. S., Marshall J. C., The Immunomodulatory Effects of Anesthetic and Analgesic Agents, in Yearbook of Intensive Care and Emergency Medicine 2002, 2002. Crossref

  172. Goumon Yannick, Casares Federico, Pryor Stephen, Ferguson Lee, Brownawell Bruce, Cadet Patrick, Rialas Christos M., Welters Ingeborg D. M., Sonetti Dario, Stefano George B., Ascaris suum, an Intestinal Parasite, Produces Morphine, The Journal of Immunology, 165, 1, 2000. Crossref

  173. Hinchliffe Taylor E., Xia Ying, Evolutionary Distribution of the δ-Opioid Receptor: From Invertebrates to Humans, in Neural Functions of the Delta-Opioid Receptor, 2015. Crossref

  174. Adzhigaliev R. R., Bautin A. E., Pasyuga V. V., Effects of general anesthesia on systemic inflammatory response during cardiac surgery with extracorporeal circulation, Complex Issues of Cardiovascular Diseases, 8, 4, 2019. Crossref

  175. Santoni Angela, Arcuri Edoardo, The ambiguity of opioids revealed by immunology is changing the knowledge and the therapeutic approach in cancer and non-cancer pain: A narrative review, Immunology Letters, 226, 2020. Crossref

  176. de la Torre J.C, Stefano G.B, Evidence that Alzheimer’s disease is a microvascular disorder: the role of constitutive nitric oxide, Brain Research Reviews, 34, 3, 2000. Crossref

  177. Mezzomo Thais Regina, Martins Cleverson Antonio Ferreira, da Silva Marcondes Daniela Beck, Mischiatti Keylla Lençone, Weffort-Santos Almeriane Maria, Assessment of the Functional Activities of Casein Phosphopeptides on Circulating Blood Leukocytes, International Journal of Peptide Research and Therapeutics, 27, 2, 2021. Crossref

  178. Murphy Glenn S., Szokol Joseph W., Marymont Jesse H., Greenberg Steven B., Avram Michael J., Vender Jeffery S., Sherwani Saadia S., Nisman Margarita, Doroski Victoria, Morphine-Based Cardiac Anesthesia Provides Superior Early Recovery Compared with Fentanyl in Elective Cardiac Surgery Patients, Anesthesia & Analgesia, 109, 2, 2009. Crossref

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  180. Murphy Glenn S., Szokol Joseph W., Marymont Jesse H., Avram Michael J., Vender Jeffery S., The Effects of Morphine and Fentanyl on the Inflammatory Response to Cardiopulmonary Bypass in Patients Undergoing Elective Coronary Artery Bypass Graft Surgery, Anesthesia & Analgesia, 104, 6, 2007. Crossref

  181. Kieffer Bruno, Dillmann Baudoin, Lefèvre Jean-François, Goumon Yannick, Aunis Dominique, Metz-Boutigue Marie-Hélène, Solution Conformation of the Synthetic Bovine Proenkephalin-A209–237 by 1H NMR Spectroscopy, Journal of Biological Chemistry, 273, 50, 1998. Crossref

  182. Gavériaux-Ruff Claire, Matthes Hans W. D., Peluso Jean, Kieffer Brigitte L., Abolition of morphine-immunosuppression in mice lacking the μ-opioid receptor gene, Proceedings of the National Academy of Sciences, 95, 11, 1998. Crossref

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  184. Siemion I. Z., Kluczyk A., Cebrat M., The peptide molecular links between the central nervous and the immune systems, Amino Acids, 29, 3, 2005. Crossref

  185. Sueoka Eisaburo, Sueoka Naoko, Kai Yasuko, Okabe Sachiko, Suganuma Masami, Kanematsu Ken, Yamamoto Tatsuo, Fujiki Hirota, Anticancer Activity of Morphine and Its Synthetic Derivative, KT-90, Mediated through Apoptosis and Inhibition of NF-κB Activation, Biochemical and Biophysical Research Communications, 252, 3, 1998. Crossref

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