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ISSN 打印: 1040-8401

ISSN 在线: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Advances in the Study of CD8+ Regulatory T Cells

卷 39, 册 6, 2019, pp. 409-421
DOI: 10.1615/CritRevImmunol.2020033260
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摘要

Immune tolerance mediated by CD4+ and CD8+ regulatory T (Treg) cells is important in the control of inflammatory and autoimmune diseases. Although CD4+FoxP3+ Treg cells are well studied, our current knowledge of the biology of CD8+ Treg cells has several critical gaps. A major limitation was our inability to distinguish them from conventional CD8+ T cells. In this regard, we have recently discovered an innate-like PLZF+CD8αα+TCRαβ+ Treg population (CD8αα Treg cells) that is enriched in the liver in naive mice and present in healthy humans. We have demonstrated that these CD8αα Treg cells serve as a feedback regulatory mechanism and target only activated effector T cells. Such feedback regulation allows the progression of an immune defense response yet prevents excessive tissue damage. It is likely that the PLZF transcription program endows the CD8αα Treg cells with the innate features that are important for them to effectively control autoimmune responses by targeting activated T cells in both mice and humans. Additional features of the CD8αα Treg cells include their dependence on IL-15/IL-2Rβ signaling, the expression of NK-inhibitory receptors, and the memory phenotype. Importantly, these cells are expanded following an ongoing immune response and serve as a feedback regulatory mechanism to control activated effector T cells, and hence prevent an excessive immune stimulation. In this review, we will briefly summarize recent important findings related to CD8+ Treg cells.

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对本文的引用
  1. Datta Syamal K., Harnessing Tolerogenic Histone Peptide Epitopes From Nucleosomes for Selective Down-Regulation of Pathogenic Autoimmune Response in Lupus (Past, Present, and Future), Frontiers in Immunology, 12, 2021. Crossref

  2. Cagnoni Alejandro J., Giribaldi María Laura, Blidner Ada G., Cutine Anabela M., Gatto Sabrina G., Morales Rosa M., Salatino Mariana, Abba Martín C., Croci Diego O., Mariño Karina V., Rabinovich Gabriel A., Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8 + regulatory T cells , Proceedings of the National Academy of Sciences, 118, 21, 2021. Crossref

  3. Yero Alexis, Shi Tao, Routy Jean-Pierre, Tremblay Cécile, Durand Madeleine, Costiniuk Cecilia T., Jenabian Mohammad-Ali, FoxP3+ CD8 T-cells in acute HIV infection and following early antiretroviral therapy initiation, Frontiers in Immunology, 13, 2022. Crossref

  4. Cox Andrew, Cevik Hilal, Feldman H. Alex, Canaday Laura M., Lakes Nora, Waggoner Stephen N., Targeting natural killer cells to enhance vaccine responses, Trends in Pharmacological Sciences, 42, 9, 2021. Crossref

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