每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
The Role of HLA-Class I Heavy-Chain Interactions with Killer-Cell Immunoglobulin-Like Receptors in Immune Regulation
摘要
HLA-class I molecules form trimeric complexes (pMHC) of peptides, class I heavy chains, and β2microglobulins (β2m) that regulate immune responses by binding to T cells and other immune receptors. B2m-free class I heavy chains (FHCs) form on cells either as a consequence of the natural turnover of pMHC or, in the case of HLA-F, are expressed without β2m. Distinct characteristics of certain HLA-class I members, such as HLA-B27 and HLA-F, stabilize these forms facilitating interactions with immune receptors. FHC forms of HLA-class I have been shown to bind to killer-cell immunoglobulin-like receptor (KIR) family members. The binding of FHC forms to KIR3DL2 regulates natural killer (NK) and T-cell functiona and promotes lymphocyte survival. KIR3DL2 binding to B27 FHC dimers has been implicated in the pathogenesis of spondyloarthritis (SpA). KIR3DL2 binding FHC forms could also play a role in immune cell recognition of certain tumors and in regulation of immune homeostasis at the maternal−fetal interface. Here, I review the evidence for the functional interaction of cell surface HLA-class I FHCs with KIR family members. I also discuss the relevance of these interactions in immune homeostasis and immune dysfunction in diseases in which FHC-binding KIRs have been implicated.
-
Chen Chen, Wang Jielin, Xu Aiqin, He Ji, Zhu Faming, Identification of the novel KIR3DL2*115 allele in a Chinese individual , HLA, 96, 1, 2020. Crossref
-
Arosa Fernando A., Esgalhado André J., Reste-Ferreira Débora, Cardoso Elsa M., Open MHC Class I Conformers: A Look through the Looking Glass, International Journal of Molecular Sciences, 22, 18, 2021. Crossref
-
Wang Yafei, Huang Jiayun, Gong Lin, Yu Dongsheng, An Chenrui, Bunpetch Varitsara, Dai Jun, Huang He, Zou Xiaohui, Ouyang Hongwei, Liu Hua, The Plasticity of Mesenchymal Stem Cells in Regulating Surface HLA-I, iScience, 15, 2019. Crossref