每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
Expanding Role of T-Cell Costimulators in Regulatory T-Cell Function: Recent Advances in Accessory Molecules Expressed on Both Regulatory and Nonregulatory T Cells
摘要
A subpopulation of T cells harbors a suppressor phenotype and can significantly dampen autoreactive CD4+ and CD8+ T-cell responses. These regulatory T (Treg) cells, which can arise naturally in the thymus and encompass a CD25+CD4+ T-cell repertoire or be antigenically induced, are central players in the maintenance of self-tolerance. A plethora of T-cell costimulatory and accessory receptor molecules expressed by Treg and/or non-regulatory T cells, such as GITR, OX40, and CTLA-4, are involved in modulating the pathogenesis of numerous autoimmune disorders, transplant rejection, and tumor immunity, as well as the control of infections. Exciting new evidence shows that T-cell costimulators, some of which are identified as hopeful discriminative Treg-cell markers, appear to mediate Treg-cell homeostasis and function. Understanding the biological significance of the T-cell costimulatory molecules and the accessory molecules expressed by Treg cells is a prerequisite to better characterizing this regulatory T-cell population. We provide a synopsis of the current understanding of several costimulatory molecules that can orchestrate the function of both naturally arising and antigen-inducible Treg cells.
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Workman Creg J., Szymczak-Workman Andrea L., Collison Lauren W., Pillai Meenu R., Vignali Dario A. A., The development and function of regulatory T cells, Cellular and Molecular Life Sciences, 66, 16, 2009. Crossref
-
Sun Z., Zhao L., Wang H., Sun L., Yi H., Zhao Y., Presence of Functional Mouse Regulatory CD4+CD25+T Cells in Xenogeneic Neonatal Porcine Thymus-Grafted Athymic Mice, American Journal of Transplantation, 6, 12, 2006. Crossref
-
Chen Shuming, Ndhlovu Lishomwa C., Takahashi Takeshi, Takeda Kazuyoshi, Ikarashi Yoshinori, Kikuchi Toshiaki, Murata Kazuko, Pandolfi Pier Paolo, Riccardi Carlo, Ono Masao, Sugamura Kazuo, Ishii Naoto, Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells, European Journal of Immunology, 38, 8, 2008. Crossref
-
Lipscomb Michael W., Taylor Jennifer L., Goldbach Cristina J., Watkins Simon C., Wesa Amy K., Storkus Walter J., DC expressing transgene Foxp3 are regulatory APC, European Journal of Immunology, 40, 2, 2010. Crossref
-
Battaglia Alessandra, Buzzonetti Alexia, Monego Giovanni, Peri Laura, Ferrandina Gabriella, Fanfani Francesco, Scambia Giovanni, Fattorossi Andrea, Neuropilin-1 expression identifies a subset of regulatory T cells in human lymph nodes that is modulated by preoperative chemoradiation therapy in cervical cancer, Immunology, 123, 1, 2008. Crossref
-
Agonistic antibodies to human glucocorticoid-induced tumor necrosis factor receptor as potential stimulators of T cell immunity for the treatment of cancer and viral infections, Expert Opinion on Therapeutic Patents, 17, 5, 2007. Crossref
-
Seo Naohiro, Takigawa Masahiro, The current status and future direction of percutaneous peptide immunization against melanoma, Journal of Dermatological Science, 48, 2, 2007. Crossref
-
Qu Yanyan, Zhao Yong, Regulatory CD4+CD25+T-cells are Controlled by Multiple Pathways at Multiple Levels, International Reviews of Immunology, 26, 3-4, 2007. Crossref
-
Seo Naohiro, Yagi Hiroaki, Hashizume Hideo, Takigawa Masahiro, Basic and clinical aspects of epidermal Langerhans cell-based percutaneous tumor-associated antigen peptide immunization, Expert Review of Dermatology, 2, 6, 2007. Crossref
-
Li M., Zhang X., Zheng X., Lian D., Zhang Z.-X., Sun H., Suzuki M., Vladau C., Huang X., Xia X., Zhong R., Garcia B., Min W.-P., Tolerogenic dendritic cells transferring hyporesponsiveness and synergizing T regulatory cells in transplant tolerance, International Immunology, 20, 2, 2008. Crossref
-
Saito Keiichi, Mori Shiro, Date Fumiko, Ono Masao, Sjögren's syndrome-like autoimmune sialadenitis in MRL-Faslprmice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand, Autoimmunity, 46, 4, 2013. Crossref
-
Ouyang Zhengxiao, Wu Hongwei, Li Linqin, Luo Yi, Li Xianan, Huang Gang, Regulatory T cells in the immunotherapy of melanoma, Tumor Biology, 37, 1, 2016. Crossref
-
Ndhlovu Lishomwa C., Loo Christopher P., Spotts Gerald, Nixon Douglas F., Hecht Frederick M., FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection, Journal of Leukocyte Biology, 83, 2, 2008. Crossref
-
Chen Shuming, Ishii Naoto, Ine Shouji, Ikeda Syuichi, Fujimura Taku, Ndhlovu Lishomwa C., Soroosh Pejman, Tada Kohtaro, Harigae Hideo, Kameoka Junichi, Kasai Noriyuki, Sasaki Takeshi, Sugamura Kazuo, Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells, International Immunology, 18, 2, 2006. Crossref
-
Chen Mei-Ling, Yan Bo-Shiun, Bando Yoshio, Kuchroo Vijay K., Weiner Howard L., Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGFβ-Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis, The Journal of Immunology, 180, 11, 2008. Crossref
-
Callahan Margaret K., Wolchok Jedd D., Allison James P., Sharma Padmanee, Immune Co-signaling to Treat Cancer, in Cancer Immunotherapy, 2013. Crossref
-
Li Bin, Wang Rong-Fu, Mechanisms and Control of Regulatory T Cells in Cancer, in Innate Immune Regulation and Cancer Immunotherapy, 2012. Crossref
-
Pardee Angela D, Wesa Amy K, Storkus Walter J, Integrating costimulatory agonists to optimize immune-based cancer therapies, Immunotherapy, 1, 2, 2009. Crossref
-
Randolph David A., Fathman C. Garrison, CD4+CD25+ Regulatory T Cells and Their Therapeutic Potential, Annual Review of Medicine, 57, 1, 2006. Crossref
-
Kondo Kayo, Okuma Kazu, Tanaka Reiko, Matsuzaki Goro, Ansari Aftab A., Tanaka Yuetsu, Rapid induction of OX40 ligand on primary T cells activated under DNA-damaging conditions, Human Immunology, 69, 9, 2008. Crossref
-
Mensink Mark, Schrama Ellen, Cuadrado Eloy, Amsen Derk, de Kivit Sander, Borst Jannie, Proteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4+ regulatory T cells, Scientific Reports, 12, 1, 2022. Crossref