每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity
摘要
Septic patients experience chronic immunosuppression resulting in enhanced susceptibility to infections normally controlled by T cells. Clinical research on septic patients has shown increased apoptosis and reduced total numbers of CD4 and CD8 T cells, suggesting contributing mechanism driving immunosuppression. Experimental models of sepsis, including cecal ligation and puncture, reverse translated this clinical observation to facilitate hypothesis-driven research and allow the use of an array of experimental tools to probe the impact of sepsis on T-cell immunity. In addition to numerical loss, sepsis functionally impairs the antigen-driven proliferative capacity and effector functions of CD4 and CD8 T cells. Sepsis-induced impairments in both the quantity and quality of T cells results in reduced protective capacity and increased susceptibility of mice to new or previously encountered infections. Therefore, the combined efforts of clinical and experimental sepsis research have begun to elucidate the impact of sepsis on T-cell-mediated immunity and potential T-cell-intrinsic and -extrinsic mechanisms driving chronic immunosuppression. Future work will explore the impact of sepsis on the recently appreciated tissue-resident memory (TRM) T cells, which provide robust protection against localized infections, and dendritic cells, which are needed to activate T cells and promote effective T-cell responses.
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Danahy Derek B., Anthony Scott M., Jensen Isaac J., Hartwig Stacey M., Shan Qiang, Xue Hai-Hui, Harty John T., Griffith Thomas S., Badovinac Vladimir P., Hildeman David A, Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells, PLOS Pathogens, 13, 9, 2017. Crossref
-
Strother Robert K., Danahy Derek B., Kotov Dmitri I., Kucaba Tamara A., Zacharias Zeb R., Griffith Thomas S., Legge Kevin L., Badovinac Vladimir P., Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo, The Journal of Immunology, 197, 11, 2016. Crossref
-
Venet Fabienne, Monneret Guillaume, Advances in the understanding and treatment of sepsis-induced immunosuppression, Nature Reviews Nephrology, 14, 2, 2018. Crossref
-
Kumar V., T cells and their immunometabolism: A novel way to understanding sepsis immunopathogenesis and future therapeutics, European Journal of Cell Biology, 97, 6, 2018. Crossref
-
Schlieckau Florian, Schulz Daniela, Fill Malfertheiner Sara, Entleutner Kathrin, Seelbach-Goebel Birgit, Ernst Wolfgang, A novel model to study neonatalEscherichia colisepsis and the effect of treatment on the human immune system using humanized mice, American Journal of Reproductive Immunology, 80, 1, 2018. Crossref
-
Abdo Joe, Cornell David L., Mittal Sumeet K., Agrawal Devendra K., Immunotherapy Plus Cryotherapy: Potential Augmented Abscopal Effect for Advanced Cancers, Frontiers in Oncology, 8, 2018. Crossref
-
Luo R.-G., Miao X.-Y., Luo L.-L., Mao B., Yu F.-Y., Xu J.-F., Presence of pldA and exoU in mucoid Pseudomonas aeruginosa is associated with high risk of exacerbations in non–cystic fibrosis bronchiectasis patients, Clinical Microbiology and Infection, 25, 5, 2019. Crossref
-
Morris Gerwyn, Maes Michael, Berk Michael, Puri Basant K., Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?, Metabolic Brain Disease, 34, 2, 2019. Crossref
-
Dzhalilova Dzhuliia Sh., Kosyreva Anna M., Diatroptov Mikhail E., Zolotova Natalia A., Tsvetkov Ivan S., Mkhitarov Vladimir A., Makarova Olga V., Khochanskiy Dmitry N., Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia, International Journal of Inflammation, 2019, 2019. Crossref
-
Méndez Raúl, Menéndez Rosario, Amara-Elori Isabel, Feced Laura, Piró Alba, Ramírez Paula, Sempere Amparo, Ortega Alicia, Bermejo-Martín Jesús F., Torres Antoni, Lymphopenic community-acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality, Journal of Infection, 78, 6, 2019. Crossref
-
Danahy Derek B., Kurup Samarchith P., Winborn Christina S., Jensen Isaac J., Harty John T., Griffith Thomas S., Badovinac Vladimir P., Sepsis-Induced State of Immunoparalysis Is Defined by Diminished CD8 T Cell–Mediated Antitumor Immunity, The Journal of Immunology, 203, 3, 2019. Crossref
-
Danahy Derek B., Jensen Isaac J., Griffith Thomas S., Badovinac Vladimir P., Cutting Edge: Polymicrobial Sepsis Has the Capacity to Reinvigorate Tumor-Infiltrating CD8 T Cells and Prolong Host Survival, The Journal of Immunology, 202, 10, 2019. Crossref
-
Imlay Hannah, Limaye Ajit P, Current Understanding of Cytomegalovirus Reactivation in Critical Illness, The Journal of Infectious Diseases, 221, Supplement_1, 2020. Crossref
-
Martin Matthew D., Badovinac Vladimir P., Griffith Thomas S., CD4 T Cell Responses and the Sepsis-Induced Immunoparalysis State, Frontiers in Immunology, 11, 2020. Crossref
-
Sjaastad Frances V., Kucaba Tamara A., Dileepan Thamotharampillai, Swanson Whitney, Dail Cody, Cabrera-Perez Javier, Murphy Katherine A., Badovinac Vladimir P., Griffith Thomas S., Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity, Frontiers in Immunology, 11, 2020. Crossref
-
Sjaastad Frances V., Jensen Isaac J., Berton Roger R., Badovinac Vladimir P., Griffith Thomas S., Inducing Experimental Polymicrobial Sepsis by Cecal Ligation and Puncture, Current Protocols in Immunology, 131, 1, 2020. Crossref
-
Zhao Dongyang, Li Zhe, Liu Xiandong, Liu Na, Bao Xiaowei, Sun Hong, Meng Qinshu, Ren Huijuan, Bai Jianwen, Zhou Xiaohui, Tang Lunxian, Lymphocyte expression of EZH2 is associated with mortality and secondary infectious complications in sepsis, International Immunopharmacology, 89, 2020. Crossref
-
Jensen Isaac J., McGonagill Patrick W., Butler Noah S., Harty John T., Griffith Thomas S., Badovinac Vladimir P., NK Cell–Derived IL-10 Supports Host Survival during Sepsis, The Journal of Immunology, 206, 6, 2021. Crossref
-
Guo Li, Shen Sikui, Rowley Jesse W., Tolley Neal D., Jia Wenwen, Manne Bhanu Kanth, McComas Kyra N., Bolingbroke Ben, Kosaka Yasuhiro, Krauel Krystin, Denorme Frederik, Jacob Shancy P., Eustes Alicia S., Campbell Robert A., Middleton Elizabeth A., He Xiao, Brown Samuel M., Morrell Craig N., Weyrich Andrew S., Rondina Matthew T., Platelet MHC class I mediates CD8+ T-cell suppression during sepsis, Blood, 138, 5, 2021. Crossref
-
Desai Pritesh, Janova Hana, White James P., Reynoso Glennys V., Hickman Heather D., Baldridge Megan T., Urban Joseph F., Stappenbeck Thaddeus S., Thackray Larissa B., Diamond Michael S., Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis, Cell, 184, 5, 2021. Crossref
-
Yao Ren-Qi, Ren Chao, Zheng Li-Yu, Xia Zhao-Fan, Yao Yong-Ming, Advances in Immune Monitoring Approaches for Sepsis-Induced Immunosuppression, Frontiers in Immunology, 13, 2022. Crossref
-
Torres Lisa K., Pickkers Peter, van der Poll Tom, Sepsis-Induced Immunosuppression, Annual Review of Physiology, 84, 1, 2022. Crossref
-
Voiriot Guillaume, Oualha Mehdi, Pierre Alexandre, Salmon-Gandonnière Charlotte, Gaudet Alexandre, Jouan Youenn, Kallel Hatem, Radermacher Peter, Vodovar Dominique, Sarton Benjamine, Stiel Laure, Bréchot Nicolas, Préau Sébastien, Joffre Jérémie, Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges, Annals of Intensive Care, 12, 1, 2022. Crossref
-
van der Poll Tom, Shankar-Hari Manu, Wiersinga W. Joost, The immunology of sepsis, Immunity, 54, 11, 2021. Crossref
-
Peng Yizhi, Wang Xiaofan, Yin Sheng, Wang Min, A new indicator: The diagnostic value of CD8+T/B lymphocyte ratio in sepsis progression, International Journal of Immunopathology and Pharmacology, 36, 2022. Crossref
-
Chen Hongyan, Zhang Xiaoting, Su Hao, Zeng Judeng, Chan Hung, Li Qing, Liu Xiaodong, Zhang Lin, Wu William Ka Kei, Chan Matthew Tak Vai, Chen Huarong, Immune dysregulation and RNA N6 ‐methyladenosine modification in sepsis , WIREs RNA, 2022. Crossref
-
Li Jingru, Sun Guihu, Ma Haocheng, Wu Xinyu, Li Chaozhong, Ding Peng, Lu Si, Li Yanyan, Yang Ping, Li Chaguo, Yang Jun, Peng Yunzhu, Meng Zhaohui, Wang Luqiao, Identification of immune-related hub genes and miRNA-mRNA pairs involved in immune infiltration in human septic cardiomyopathy by bioinformatics analysis, Frontiers in Cardiovascular Medicine, 9, 2022. Crossref
-
Luperto Marta, Zafrani Lara, T cell dysregulation in inflammatory diseases in ICU, Intensive Care Medicine Experimental, 10, 1, 2022. Crossref
-
Xu Lei, Wei Chuan, Chen Ying, Wu Yue, Shou Xiaoli, Chen Wenjie, Lu Di, Sun Haoran, Li Wei, Yu Beibei, Wang Xiaowei, Zhang Xiaojun, Yu Yanxiong, Lei Zhigang, Tang Rui, Zhu Jifeng, Li Yalin, Lu Linrong, Zhou Hong, Zhou Sha, Su Chuan, Chen Xiaojun, IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection, Nature Communications, 13, 1, 2022. Crossref
-
Yan Lei, Chen Yumei, Han Yi, Tong Chaoyang, Role of CD8+ T cell exhaustion in the progression and prognosis of acute respiratory distress syndrome induced by sepsis: a prospective observational study, BMC Emergency Medicine, 22, 1, 2022. Crossref