图书馆订阅: Guest
免疫学评论综述™

每年出版 6 

ISSN 打印: 1040-8401

ISSN 在线: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Structure and Function of Cas-L and Integrin-Mediated Signaling

卷 26, 册 5, 2006, pp. 391-406
DOI: 10.1615/CritRevImmunol.v26.i5.20
Get accessGet access

摘要

Cas-L (Crk-associated substrate lymphocyte type), also known as HEF1 (human enhancer of filamentation 1) or NEDD9 (neural precursor cell-expressed, developmentally downregulated gene 9), is an adapter protein at focal adhesions and transmits various signals, mainly induced by integrins. Cas-L is a member of the Cas family proteins and is expressed preferentially in lymphocytes and epithelial cells. A number of previous studies have suggested that Cas-L plays an important role in lymphocyte movement and cell cycle. Recently, we reported a novel function of Cas-L in the immune system using gene-targeted mice. The Cas-L-deficient lymphocytes showed insufficient chemotactic response and perturbed сеll adhesion. Moreover, a deficit of marginal zone (MZ) B cells was detected in the mutant mice. Here, we review the structure of Cas-L and several signaling pathways in which Cas-L is involved, based on the previous in vitro studies. Subsequently, biological functions of Cas-L and the relevance of Cas-L to human diseases are discussed.

对本文的引用
  1. Nakamoto Tetsuya, Seo Sachiko, Sakai Ryuichi, Kato Takayuki, Kutsuna Haruo, Kurokawa Mineo, Noda Masaki, Miyasaka Nobuyuki, Kitagawa Seiichi, Expression and tyrosine phosphorylation of Crk-associated substrate lymphocyte type (Cas-L) protein in human neutrophils, Journal of Cellular Biochemistry, 105, 1, 2008. Crossref

  2. Singh Mahendra K., Cowell Lauren, Seo Sachiko, O’Neill Geraldine M., Golemis Erica A., Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle, Cell Biochemistry and Biophysics, 48, 1, 2007. Crossref

  3. Alexandropoulos Konstantina, Regelmann Adam G., Regulation of T-lymphocyte physiology by the Chat-H/CasL adapter complex, Immunological Reviews, 232, 1, 2009. Crossref

  4. Tikhmyanova Nadezhda, Little Joy L., Golemis Erica A., CAS proteins in normal and pathological cell growth control, Cellular and Molecular Life Sciences, 67, 7, 2010. Crossref

  5. Shi Rongfeng, Wang Lei, Wang Tao, Xu Junfei, Wang Feiran, Xu Meirong, NEDD9 overexpression correlates with the progression and prognosis in gastric carcinoma, Medical Oncology, 31, 3, 2014. Crossref

  6. Seo Sachiko, Nakamoto Tetsuya, Takeshita Masataka, Lu Jun, Sato Tomohiko, Suzuki Takahiro, Kamikubo Yasuhiko, Ichikawa Motoshi, Noda Masaki, Ogawa Seishi, Honda Hiroaki, Oda Hideaki, Kurokawa Mineo, Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl, Cancer Science, 102, 12, 2011. Crossref

  7. Li Xiaolan, Luo Xuelai, Li Zhaoming, Wang Guihua, Xiao Hui, Tao Deding, Gong Jianping, Hu Junbo, Screening of binding proteins that interact with human Salvador 1 in a human fetal liver cDNA library by the yeast two-hybrid system, Molecular Biology Reports, 39, 8, 2012. Crossref

  8. Braiman Alex, Isakov Noah, The Role of Crk Adaptor Proteins in T-Cell Adhesion and Migration, Frontiers in Immunology, 6, 2015. Crossref

  9. Shagisultanova Elena, Gaponova Anna V., Gabbasov Rashid, Nicolas Emmanuelle, Golemis Erica A., Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases, Gene, 567, 1, 2015. Crossref

  10. HAN TONG, YI XIAO-PING, LIU BO, KE MU-JING, LI YI-XIONG, MicroRNA-145 suppresses cell proliferation, invasion and migration in pancreatic cancer cells by targeting NEDD9, Molecular Medicine Reports, 11, 6, 2015. Crossref

  11. Santos Luís C, Blair David A, Kumari Sudha, Cammer Michael, Iskratsch Thomas, Herbin Olivier, Alexandropoulos Konstantina, Dustin Michael L, Sheetz Michael P, Actin polymerization‐dependent activation of Cas‐L promotes immunological synapse stability, Immunology & Cell Biology, 94, 10, 2016. Crossref

  12. Zheng Hong, Wu Jianbo, Shi Jiachen, Lu Chunya, Wang Yuanyuan, Sun Qianqian, Zhang Guojun, Zhao Guoqiang, miR-125a-5p upregulation suppresses the proliferation and induces the cell apoptosis of lung adenocarcinoma by targeting NEDD9, Oncology Reports, 38, 3, 2017. Crossref

  13. Bui L -C, Tomkiewicz C, Chevallier A, Pierre S, Bats A -S, Mota S, Raingeaud J, Pierre J, Diry M, Transy C, Garlatti M, Barouki R, Coumoul X, Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity, Oncogene, 28, 41, 2009. Crossref

  14. O'Neill Geraldine M., Seo Sachiko, Serebriiskii Ilya G., Lessin Stuart R., Golemis Erica A., A New Central Scaffold for Metastasis: Parsing HEF1/Cas-L/NEDD9, Cancer Research, 67, 19, 2007. Crossref

  15. Browne Cecille D., Hoefer Melanie M., Chintalapati Suresh K., Cato Matthew H., Wallez Yann, Ostertag Derek V., Pasquale Elena B., Rickert Robert C., SHEP1 partners with CasL to promote marginal zone B-cell maturation, Proceedings of the National Academy of Sciences, 107, 44, 2010. Crossref

  16. Jones Brandon C., Kelley Laura C., Loskutov Yuriy V., Marinak Kristina M., Kozyreva Varvara K., Smolkin Matthew B., Pugacheva Elena N., Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior, Molecular Cancer Research, 15, 6, 2017. Crossref

将发表的论文

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain