每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
Structure and Function of Cas-L and Integrin-Mediated Signaling
摘要
Cas-L (Crk-associated substrate lymphocyte type), also known as HEF1 (human enhancer of filamentation 1) or NEDD9 (neural precursor cell-expressed, developmentally downregulated gene 9), is an adapter protein at focal adhesions and transmits various signals, mainly induced by integrins. Cas-L is a member of the Cas family proteins and is expressed preferentially in lymphocytes and epithelial cells. A number of previous studies have suggested that Cas-L plays an important role in lymphocyte movement and cell cycle. Recently, we reported a novel function of Cas-L in the immune system using gene-targeted mice. The Cas-L-deficient lymphocytes showed insufficient chemotactic response and perturbed сеll adhesion. Moreover, a deficit of marginal zone (MZ) B cells was detected in the mutant mice. Here, we review the structure of Cas-L and several signaling pathways in which Cas-L is involved, based on the previous in vitro studies. Subsequently, biological functions of Cas-L and the relevance of Cas-L to human diseases are discussed.
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Nakamoto Tetsuya, Seo Sachiko, Sakai Ryuichi, Kato Takayuki, Kutsuna Haruo, Kurokawa Mineo, Noda Masaki, Miyasaka Nobuyuki, Kitagawa Seiichi, Expression and tyrosine phosphorylation of Crk-associated substrate lymphocyte type (Cas-L) protein in human neutrophils, Journal of Cellular Biochemistry, 105, 1, 2008. Crossref
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Singh Mahendra K., Cowell Lauren, Seo Sachiko, O’Neill Geraldine M., Golemis Erica A., Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle, Cell Biochemistry and Biophysics, 48, 1, 2007. Crossref
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Alexandropoulos Konstantina, Regelmann Adam G., Regulation of T-lymphocyte physiology by the Chat-H/CasL adapter complex, Immunological Reviews, 232, 1, 2009. Crossref
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Tikhmyanova Nadezhda, Little Joy L., Golemis Erica A., CAS proteins in normal and pathological cell growth control, Cellular and Molecular Life Sciences, 67, 7, 2010. Crossref
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Shi Rongfeng, Wang Lei, Wang Tao, Xu Junfei, Wang Feiran, Xu Meirong, NEDD9 overexpression correlates with the progression and prognosis in gastric carcinoma, Medical Oncology, 31, 3, 2014. Crossref
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Seo Sachiko, Nakamoto Tetsuya, Takeshita Masataka, Lu Jun, Sato Tomohiko, Suzuki Takahiro, Kamikubo Yasuhiko, Ichikawa Motoshi, Noda Masaki, Ogawa Seishi, Honda Hiroaki, Oda Hideaki, Kurokawa Mineo, Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl, Cancer Science, 102, 12, 2011. Crossref
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Li Xiaolan, Luo Xuelai, Li Zhaoming, Wang Guihua, Xiao Hui, Tao Deding, Gong Jianping, Hu Junbo, Screening of binding proteins that interact with human Salvador 1 in a human fetal liver cDNA library by the yeast two-hybrid system, Molecular Biology Reports, 39, 8, 2012. Crossref
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Braiman Alex, Isakov Noah, The Role of Crk Adaptor Proteins in T-Cell Adhesion and Migration, Frontiers in Immunology, 6, 2015. Crossref
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Shagisultanova Elena, Gaponova Anna V., Gabbasov Rashid, Nicolas Emmanuelle, Golemis Erica A., Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases, Gene, 567, 1, 2015. Crossref
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HAN TONG, YI XIAO-PING, LIU BO, KE MU-JING, LI YI-XIONG, MicroRNA-145 suppresses cell proliferation, invasion and migration in pancreatic cancer cells by targeting NEDD9, Molecular Medicine Reports, 11, 6, 2015. Crossref
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Santos Luís C, Blair David A, Kumari Sudha, Cammer Michael, Iskratsch Thomas, Herbin Olivier, Alexandropoulos Konstantina, Dustin Michael L, Sheetz Michael P, Actin polymerization‐dependent activation of Cas‐L promotes immunological synapse stability, Immunology & Cell Biology, 94, 10, 2016. Crossref
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Zheng Hong, Wu Jianbo, Shi Jiachen, Lu Chunya, Wang Yuanyuan, Sun Qianqian, Zhang Guojun, Zhao Guoqiang, miR-125a-5p upregulation suppresses the proliferation and induces the cell apoptosis of lung adenocarcinoma by targeting NEDD9, Oncology Reports, 38, 3, 2017. Crossref
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Bui L -C, Tomkiewicz C, Chevallier A, Pierre S, Bats A -S, Mota S, Raingeaud J, Pierre J, Diry M, Transy C, Garlatti M, Barouki R, Coumoul X, Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity, Oncogene, 28, 41, 2009. Crossref
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O'Neill Geraldine M., Seo Sachiko, Serebriiskii Ilya G., Lessin Stuart R., Golemis Erica A., A New Central Scaffold for Metastasis: Parsing HEF1/Cas-L/NEDD9, Cancer Research, 67, 19, 2007. Crossref
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Browne Cecille D., Hoefer Melanie M., Chintalapati Suresh K., Cato Matthew H., Wallez Yann, Ostertag Derek V., Pasquale Elena B., Rickert Robert C., SHEP1 partners with CasL to promote marginal zone B-cell maturation, Proceedings of the National Academy of Sciences, 107, 44, 2010. Crossref
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Jones Brandon C., Kelley Laura C., Loskutov Yuriy V., Marinak Kristina M., Kozyreva Varvara K., Smolkin Matthew B., Pugacheva Elena N., Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior, Molecular Cancer Research, 15, 6, 2017. Crossref