图书馆订阅: Guest
免疫学评论综述™

每年出版 6 

ISSN 打印: 1040-8401

ISSN 在线: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Modulation of the ATP-lnduced Release and Processing of IL-1β in Microglial Cells

卷 29, 册 4, 2009, pp. 335-345
DOI: 10.1615/CritRevImmunol.v29.i4.40
Get accessGet access

摘要

IL-1β is one of the most potent proinflammatory cytokines. It is primarily released from activated microglia in the brain, and is also implicated in the induction and progression of pathogenesis in various neurodegenerative disorders. Therefore, to clarify the regulatory or modulatory mechanisms for maturation and release of IL-1β from microglia may provide therapeutic clues for neuroinflammatory/neurodegenerative diseases. IL-1β lacks a secretory signal sequence, and thus is not transported through the classical cndoplasmic reticulum/ Golgi-mediated pathway. Although the mechanisms for the release of mature IL-1β still remain controversial, emerging evidence suggests the pivotal roles of the P2X7 receptor (P2X7R), one of the ionotropic P2X receptors for extracellular ATP, in the release of this cytokine. Here, we review the current studies regarding the modulatory mechanisms of P2X7R-dependent maturation and the release of IL-1β from microglial cells, focusing on the novel roles of lysophospholipids in this process.

对本文的引用
  1. Marques-da-Silva C, Chaves MM, Castro NG, Coutinho-Silva R, Guimaraes MZP, Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action, British Journal of Pharmacology, 163, 5, 2011. Crossref

  2. Weisman Gary A., Camden Jean M., Peterson Troy S., Ajit Deepa, Woods Lucas T., Erb Laurie, P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation, Molecular Neurobiology, 46, 1, 2012. Crossref

  3. Chen Meng-Ling, Cao Hong, Chu Yu-Xia, Cheng Long-Zhen, Liang Ling-Li, Zhang Yu-Qiu, Zhao Zhi-Qi, Role of P2X7 Receptor-Mediated IL-18/IL-18R Signaling in Morphine Tolerance: Multiple Glial-Neuronal Dialogues in the Rat Spinal Cord, The Journal of Pain, 13, 10, 2012. Crossref

  4. Peterson Troy S., Thebeau Christina N., Ajit Deepa, Camden Jean M., Woods Lucas T., Wood W. Gibson, Petris Michael J., Sun Grace Y., Erb Laurie, Weisman Gary A., Up-regulation and activation of the P2Y2 nucleotide receptor mediate neurite extension in IL-1β-treated mouse primary cortical neurons, Journal of Neurochemistry, 125, 6, 2013. Crossref

  5. Kong Fanjun, Liu Shuangmei, Xu Changshui, Liu Jun, Li Guodong, Li Guilin, Gao Yun, Lin Hong, Tu Guihua, Peng Haiying, Qiu Shuyi, Fan Bo, Zhu Qicheng, Yu Shicheng, Zheng Chaoran, Liang Shangdong, Electrophysiological studies of upregulated P2X7 receptors in rat superior cervical ganglia after myocardial ischemic injury, Neurochemistry International, 63, 3, 2013. Crossref

  6. Huang Zhang Xiang, Lu Zhi Jie, Ma Wei Qing, Wu Fei Xiang, Zhang Yu Qiu, Yu Wei-Feng, Zhao Zhi Qi, Involvement of RVM-expressed P2X7 receptor in bone cancer pain: Mechanism of descending facilitation, Pain, 155, 4, 2014. Crossref

  7. Takenouchi Takato, Sekiyama Kazunari, Sekigawa Akio, Fujita Masayo, Waragai Masaaki, Sugama Shuei, Iwamaru Yoshifumi, Kitani Hiroshi, Hashimoto Makoto, P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases, Archivum Immunologiae et Therapiae Experimentalis, 58, 2, 2010. Crossref

  8. Hu Xiaoming, Liou Anthony K.F., Leak Rehana K., Xu Mingyue, An Chengrui, Suenaga Jun, Shi Yejie, Gao Yanqin, Zheng Ping, Chen Jun, Neurobiology of microglial action in CNS injuries: Receptor-mediated signaling mechanisms and functional roles, Progress in Neurobiology, 119-120, 2014. Crossref

  9. Kitani Hiroshi, Sakuma Chisato, Takenouchi Takato, Sato Mitsuru, Yoshioka Miyako, Yamanaka Noriko, Establishment of c-myc-immortalized Kupffer cell line from a C57BL/6 mouse strain, Results in Immunology, 4, 2014. Crossref

  10. Du Dongshu, Jiang Meiyan, Liu Min, Wang Jin, Xia Chunmei, Guan Ruijuan, Shen Linlin, Ji Yonghua, Zhu Danian, Microglial P2X7 receptor in the hypothalamic paraventricular nuclei contributes to sympathoexcitatory responses in acute myocardial infarction rat, Neuroscience Letters, 587, 2015. Crossref

  11. Kim Jong-Youl, Kim Nuri, Yenari Midori A., Mechanisms and Potential Therapeutic Applications of Microglial Activation after Brain Injury, CNS Neuroscience & Therapeutics, 21, 4, 2015. Crossref

  12. Erb Laurie, Cao Chen, Ajit Deepa, Weisman Gary A., P2Y receptors in Alzheimer's disease, Biology of the Cell, 107, 1, 2015. Crossref

  13. Sáez Pablo J., Shoji Kenji F., Retamal Mauricio A., Harcha Paloma A., Ramírez Gigliola, Jiang Jean X., von Bernhardi Rommy, Sáez Juan C., ATP Is Required and Advances Cytokine-Induced Gap Junction Formation in Microglia In Vitro, Mediators of Inflammation, 2013, 2013. Crossref

  14. Kitani Hiroshi, Yoshioka Miyako, Takenouchi Takato, Sato Mitsuru, Yamanaka Noriko, Characterization of the liver-macrophages isolated from a mixed primary culture of neonatal swine hepatocytes, Results in Immunology, 4, 2014. Crossref

  15. Falk S., Schwab S.D., Frøsig-Jørgensen M., Clausen R.P., Dickenson A.H., Heegaard A.-M., P2X7 receptor-mediated analgesia in cancer-induced bone pain, Neuroscience, 291, 2015. Crossref

  16. Ott Daniela, Murgott Jolanta, Rafalzik Sandra, Wuchert Florian, Schmalenbeck Babette, Roth Joachim, Gerstberger Rüdiger, Neurons and glial cells of the rat organum vasculosum laminae terminalis directly respond to lipopolysaccharide and pyrogenic cytokines, Brain Research, 1363, 2010. Crossref

  17. Weisman Gary A., Ajit Deepa, Garrad Richard, Peterson Troy S., Woods Lucas T., Thebeau Christina, Camden Jean M., Erb Laurie, Neuroprotective roles of the P2Y2 receptor, Purinergic Signalling, 8, 3, 2012. Crossref

  18. Bjelobaba Ivana, Parabucki Ana, Lavrnja Irena, Stojkov Danijela, Dacic Sanja, Pekovic Sanja, Rakic Ljubisa, Stojiljkovic Mirjana, Nedeljkovic Nadezda, Dynamic changes in the expression pattern of ecto-5′-nucleotidase in the rat model of cortical stab injury, Journal of Neuroscience Research, 89, 6, 2011. Crossref

  19. Lenertz Lisa Y., Gavala Monica L., Zhu Yiming, Bertics Paul J., Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions, Immunologic Research, 50, 1, 2011. Crossref

  20. Yenari Midori A., Kauppinen Tiina M., Swanson Raymond A., Microglial activation in stroke: Therapeutic targets, Neurotherapeutics, 7, 4, 2010. Crossref

  21. Tewari Manju, Seth Pankaj, Emerging role of P2X7 receptors in CNS health and disease, Ageing Research Reviews, 24, 2015. Crossref

  22. Takenouchi Takato, Iwamaru Yoshifumi, Sugama Shuei, Tsukimoto Mitsutoshi, Fujita Masayo, Sekigawa Akio, Sekiyama Kazunari, Sato Mitsuru, Kojima Shuji, Conti Bruno, Hashimoto Makoto, Kitani Hiroshi, The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1β under acidic extracellular pH in LPS-primed microglial cells, Journal of Neurochemistry, 2011. Crossref

  23. Kim Hye Jung, Ajit Deepa, Peterson Troy S., Wang Yanfang, Camden Jean M., Gibson Wood W., Sun Grace Y., Erb Laurie, Petris Michael, Weisman Gary A., Nucleotides released from Aβ1-42-treated microglial cells increase cell migration and Aβ1-42 uptake through P2Y2 receptor activation, Journal of Neurochemistry, 121, 2, 2012. Crossref

  24. Zhang Qingxiu, Cheng Hongyu, Rong Rong, Yang Hui, Ji Qiuhong, Li Qingjie, Rong Liangqun, Hu Gang, Xu Yun, The Effect of PSD-93 Deficiency on the Expression of Early Inflammatory Cytokines Induced by Ischemic Brain Injury, Cell Biochemistry and Biophysics, 73, 3, 2015. Crossref

  25. Massicot France, Hache Guillaume, David Ludivine, Chen Dominique, Leuxe Charlotte, Garnier-Legrand Laure, Rat Patrice, Laprévote Olivier, Coudoré François, Mukhopadhyay Partha, P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach, PLoS ONE, 8, 6, 2013. Crossref

  26. WANG YONG-CHAO, CUI YING, CUI JIAN-ZHONG, SUN LI-QIAN, CUI CHANG-MENG, ZHANG HONG-AO, ZHU HUI-XING, LI RAN, TIAN YAN-XIA, GAO JUN-LING, Neuroprotective effects of brilliant blue G on the brain following traumatic brain injury in rats, Molecular Medicine Reports, 12, 2, 2015. Crossref

  27. Burm Saskia Maria, Zuiderwijk-Sick Ella Alwine, Weert Paola Massiel, Bajramovic Jeffrey John, ATP-induced IL-1β secretion is selectively impaired in microglia as compared to hematopoietic macrophages, Glia, 64, 12, 2016. Crossref

  28. Iwamaru Yoshifumi, Takenouchi Takato, Murayama Yuichi, Okada Hiroyuki, Imamura Morikazu, Shimizu Yoshihisa, Hashimoto Makoto, Mohri Shirou, Yokoyama Takashi, Kitani Hiroshi, Lasmezas Corinne Ida, Anti-Prion Activity of Brilliant Blue G, PLoS ONE, 7, 5, 2012. Crossref

  29. Yang Fuxing, Zhao Kai, Zhang Xiufeng, Zhang Jun, Xu Bainan, ATP Induces Disruption of Tight Junction Proteins via IL-1 Beta-Dependent MMP-9 Activation of Human Blood-Brain BarrierIn Vitro, Neural Plasticity, 2016, 2016. Crossref

  30. Woods Lucas T., Camden Jean M., Batek Josef M., Petris Michael J., Erb Laurie, Weisman Gary A., P2X7 receptor activation induces inflammatory responses in salivary gland epithelium, American Journal of Physiology-Cell Physiology, 303, 7, 2012. Crossref

  31. Aronica Eleonora, Bauer Sebastian, Bozzi Yuri, Caleo Matteo, Dingledine Raymond, Gorter Jan A., Henshall David C., Kaufer Daniela, Koh Sookyong, Löscher Wolfgang, Louboutin Jean-Pierre, Mishto Michele, Norwood Braxton A., Palma Eleonora, Poulter Michael O., Terrone Gaetano, Vezzani Annamaria, Kaminski Rafal M., Neuroinflammatory targets and treatments for epilepsy validated in experimental models, Epilepsia, 58, 2017. Crossref

  32. Krueger James M., Taishi Ping, De Alok, Davis Christopher J., Winters Bradley D., Clinton James, Szentirmai Éva, Zielinski Mark R., ATP and the purine type 2 X7 receptor affect sleep, Journal of Applied Physiology, 109, 5, 2010. Crossref

  33. Kimbler Donald E., Shields Jessica, Yanasak Nathan, Vender John R., Dhandapani Krishnan M., Kleinschnitz Christoph, Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice, PLoS ONE, 7, 7, 2012. Crossref

  34. Bergenfelz Caroline, Hakansson Anders P, Streptococcus pneumoniae Otitis Media Pathogenesis and How It Informs Our Understanding of Vaccine Strategies, Current Otorhinolaryngology Reports, 5, 2, 2017. Crossref

  35. Freire Daniel, Reyes Rachel E., Baghram Ared, Davies Daryl L., Asatryan Liana, P2X7 Receptor Antagonist A804598 Inhibits Inflammation in Brain and Liver in C57BL/6J Mice Exposed to Chronic Ethanol and High Fat Diet, Journal of Neuroimmune Pharmacology, 14, 2, 2019. Crossref

  36. Yang Rongrong, Wang Hui, Wen Jie, Ma Kai, Chen Dongjian, Chen Zhuo, Huang Chao, Regulation of microglial process elongation, a featured characteristic of microglial plasticity, Pharmacological Research, 139, 2019. Crossref

  37. Calovi Stefano, Mut-Arbona Paula, Sperlágh Beáta, Microglia and the Purinergic Signaling System, Neuroscience, 405, 2019. Crossref

  38. Lu Yun‐Bi, Chen Chen‐Xiang, Huang Jing, Tian Yu‐Xin, Xie Xian, Yang Ping, Wu Ming, Tang Chun, Zhang Wei‐Ping, Nicotinamide phosphoribosyltransferase secreted from microgliaviaexosome during ischemic injury, Journal of Neurochemistry, 150, 6, 2019. Crossref

  39. Lu Lei, Armstrong Edward A., Yager Jerome Y., Unsworth Larry D., Sustained Release of Dexamethasone from Sulfobutyl Ether β‐cyclodextrin Modified Self‐Assembling Peptide Nanoscaffolds in a Perinatal Rat Model of Hypoxia–Ischemia, Advanced Healthcare Materials, 8, 11, 2019. Crossref

  40. Kim Ji-Eun, Ryu Hea Jin, Yeo Seong-Il, Kang Tae-Cheon, P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus, Journal of Neuroinflammation, 7, 1, 2010. Crossref

  41. Xu Jin, Chen Xue-Mei, Zheng Bei-Jie, Wang Xiang-Rui, Electroacupuncture Relieves Nerve Injury–Induced Pain Hypersensitivity via the Inhibition of Spinal P2X7 Receptor–Positive Microglia, Anesthesia & Analgesia, 122, 3, 2016. Crossref

  42. Zarei Malek, Sahebi Vaighan Navideh, Ziai Seyed Ali, Purinergic receptor ligands: the cytokine storm attenuators, potential therapeutic agents for the treatment of COVID-19, Immunopharmacology and Immunotoxicology, 43, 6, 2021. Crossref

  43. Ernest James Phillips Thomas, Maguire Emily, Phosphoinositides: Roles in the Development of Microglial-Mediated Neuroinflammation and Neurodegeneration, Frontiers in Cellular Neuroscience, 15, 2021. Crossref

  44. Nörenberg Wolfgang, Hempel Christoph, Urban Nicole, Sobottka Helga, Illes Peter, Schaefer Michael, Clemastine Potentiates the Human P2X7 Receptor by Sensitizing It to Lower ATP Concentrations, Journal of Biological Chemistry, 286, 13, 2011. Crossref

  45. Zeng Yeting, Luo Huoqing, Gao Zilong, Zhu Xiaona, Shen Yinbo, Li Yulong, Hu Ji, Yang Jiajun, Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine, iScience, 24, 3, 2021. Crossref

  46. Huang Zeyi, Tan Sijie, P2X7 Receptor as a Potential Target for Major Depressive Disorder, Current Drug Targets, 22, 10, 2021. Crossref

将发表的论文

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain