图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
器官移植长期效应期刊
SJR: 0.145 SNIP: 0.491 CiteScore™: 0.89

ISSN 打印: 1050-6934
ISSN 在线: 1940-4379

器官移植长期效应期刊

DOI: 10.1615/JLongTermEffMedImplants.v20.i4.30
pages 277-293

Long-Term Effects of Bone Morphogenetic Protein- Based Treatments in Humans

Martin V. Burks
School of Medicine, University of Virginia, Charlottesville, Virginia
Lakshmi Nair
Department of Orthopaedic Surgery, University of Connecticut Health Center; Department of Chemical, Materials and Biomolecular Engineering, Biomedical Engineering, Institute of Material Science, University of Connecticut

ABSTRACT

Bone morphogenetic proteins (BMPs) are low-molecular-weight proteins of the transforming growth factor-beta (TGF-β) superfamily. In recent years, these growth and differentiation factors have been extensively researched for their multifunctional properties ranging from embryonic development to postnatal homeostasis. The defining ability of BMPs is the role they play in skeletal development and maintenance, especially the powerful osteoinductive activity for which these proteins are currently sought after. There are over 20 BMPs that have been discovered, with BMP-2 and BMP-7 currently being the only proteins of the group that are approved by the US Food and Drug Administration for clinical use as an autograft substitute for lumbar spinal interbody fusion procedures and for open tibial fractures with intramedullary nail fixation. BMP-2 has also been approved for use in dental bone grafting indications. However, a significant amount of off-label usage of these proteins has been reported, which has led to an industry approaching a billion dollars annually. In this review, we examine the long-term effects of BMPs as evidenced from in vitro, preclinical, and clinical studies.


Articles with similar content:

Preface: Bone Graft Materials
Journal of Long-Term Effects of Medical Implants, Vol.20, 2010, issue 4
Sachin S. Mamidwar
Factors Influencing the Long-Term Behavior of Extracellular Matrix-Derived Scaffolds for Musculoskeletal Soft Tissue Repair
Journal of Long-Term Effects of Medical Implants, Vol.22, 2012, issue 3
Christopher R. Rowland, Farshid Guilak, Dianne Little
Scaffolds for Tissue Engineering of Cartilage
Critical Reviews™ in Eukaryotic Gene Expression, Vol.12, 2002, issue 3
J. M. Bezemer, C. A. van Blitterswijk, J. Riesle, T. B. F. Woodfield, J. S. Pieper
Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants
Journal of Long-Term Effects of Medical Implants, Vol.21, 2011, issue 2
Syam P. Nukavarapu, Ami R. Amini, James S. Wallace
Dental Tissue−Derived Mesenchymal Stem Cells: Applications in Tissue Engineering
Critical Reviews™ in Biomedical Engineering, Vol.46, 2018, issue 5
Jay R. Dave, Geetanjali B. Tomar