图书馆订阅: Guest
环境病理学,毒理学和肿瘤学期刊

每年出版 4 

ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Eupatilin Inhibits Proliferation of ras-Transformed Human Breast Epithelial (MCF-10A-ras) Cells

卷 24, 册 4, 2005, pp. 251-260
DOI: 10.1615/JEnvironPatholToxicolOncol.v24.i4.20
Get accessGet access

摘要

Artemisia asiatica Nakai has been used frequently in traditional Asian medicine for the treatment of inflammation and cancer. Eupatilin (5,7-dihydroxy-3′,4′, 6-trimethoxy-flavone) was shown to be a pharmacologically active ingredient of A. asiatica. In the present study, we found that expression of cyclin D1, a key protein that regulates G1/S progression, was decreased in MCF-10A-ras cells treated with eupatilin. Downregulation of cyclin D1 expression by eupatilin was accompanied by a reduced expression of c-Jun and the DNA binding activity of the transcription factor AP-l. The expression of p21waf1/Cip1 was also decreased by eupatilin treatment in both protein and the mRNA levels. We concluded that the inhibitory effect of eupatilin on p21waf1/Cip1 expression is likely to be associated with the downregulation of cyclin D1 expression and AP-1 activation, which play an important role in the cell cycle arrest of ras-transformed breast epithelial cells.

对本文的引用
  1. Gómez-Serranillos Cuadrado María, Ortega Hernández-Agero María, Palomino Ruiz-Poveda Olga, Carretero Accame María, Advances in Medicinal Plants with Antitumoral Activity, in Medicinal Plants, 2012. Crossref

  2. Park Byeong Bae, Yoon Jin sun, Kim Eun shil, Choi Jiyoung, Won Young woong, Choi Jung hye, Lee Young Yiul, Inhibitory effects of eupatilin on tumor invasion of human gastric cancer MKN-1 cells, Tumor Biology, 34, 2, 2013. Crossref

  3. Yoon Kee Dong, Chin Young-Won, Yang Min Hye, Kim Jinwoong, Separation of anti-ulcer flavonoids from Artemisia extracts by high-speed countercurrent chromatography, Food Chemistry, 129, 2, 2011. Crossref

  4. Choi Seul Min, Shin Jee Hyun, Kang Kyung Koo, Ahn Byoung Ok, Yoo Moohi, Gastroprotective Effects of DA-6034, a New Flavonoid Derivative, in Various Gastric Mucosal Damage Models, Digestive Diseases and Sciences, 52, 11, 2007. Crossref

  5. Kim Young-Dae, Choi Suck-Chei, Oh Tae-Young, Chun Jang-Soo, Jun Chang-Duk, Eupatilin inhibits T-cell activation by modulation of intracellular calcium flux and NF-κB and NF-AT activity, Journal of Cellular Biochemistry, 108, 1, 2009. Crossref

  6. Choi Eun-Ju, Oh Hyun-Mee, Na Bo-Ra, Ramesh T. P., Lee Hyun-Ju, Choi Chang-Soo, Choi Suck-Chei, Oh Tae-Young, Choi Suck-Jun, Chae Jeong-Ryong, Kim Sang-Wook, Jun Chang-Duk, Eupatilin Protects Gastric Epithelial Cells from Oxidative Damage and Down-Regulates Genes Responsible for the Cellular Oxidative Stress, Pharmaceutical Research, 25, 6, 2008. Crossref

  7. Choi Eun-Ju, Oh Hyun-Mee, Wee Hyun, Choi Chang-Soo, Choi Suck-Chei, Kim Ki-Hoon, Han Weon-Cheol, Oh Tae-Young, Kim Sang-Hyun, Jun Chang-Duk, Eupatilin exhibits a novel anti-tumor activity through the induction of cell cycle arrest and differentiation of gastric carcinoma AGS cells, Differentiation, 77, 4, 2009. Crossref

  8. Abdel Latif Nehad A., Batran Rasha Z., Khedr Mohammed A., Abdalla Mohamed M., 3-Substituted-4-hydroxycoumarin as a new scaffold with potent CDK inhibition and promising anticancer effect: Synthesis, molecular modeling and QSAR studies, Bioorganic Chemistry, 67, 2016. Crossref

  9. WANG YAWEI, HOU HONGWEI, LI MING, YANG YANG, SUN LAN, Anticancer effect of eupatilin on glioma cells through inhibition of the Notch-1 signaling pathway, Molecular Medicine Reports, 13, 2, 2016. Crossref

  10. Zhao Yingke, Liu Yue, A mechanistic overview of herbal medicine and botanical compounds to target transcriptional factors in Breast cancer, Pharmacological Research, 130, 2018. Crossref

  11. Mirzahosseini Golnoush, Manayi Azadeh, Khanavi Mahnaz, Safavi Maliheh, Salari Ali, Madjid Ansari Alireza, San’ati Hassan, Vazirian Mahdi, Bio-guided isolation of Centaurea bruguierana subsp. belangerana cytotoxic components, Natural Product Research, 33, 11, 2019. Crossref

  12. KIM M.-J., KIM D.-H., LEE K. W., YOON D.-Y., SURH Y.-J., Jaceosidin Induces Apoptosis in ras-Transformed Human Breast Epithelial Cells through Generation of Reactive Oxygen Species, Annals of the New York Academy of Sciences, 1095, 1, 2007. Crossref

  13. Abd El-Karim Somaia S., Syam Yasmin M., El Kerdawy Ahmed M., Abdelghany Tamer M., New thiazol-hydrazono-coumarin hybrids targeting human cervical cancer cells: Synthesis, CDK2 inhibition, QSAR and molecular docking studies, Bioorganic Chemistry, 86, 2019. Crossref

  14. Serttas Riza, Koroglu Cagla, Erdogan Suat, Eupatilin Inhibits the Proliferation and Migration of Prostate Cancer Cells through Modulation of PTEN and NF-κB Signaling, Anti-Cancer Agents in Medicinal Chemistry, 21, 3, 2021. Crossref

  15. Ju Hyun-Mok, Yu Kwang-Won, Cho Sung-Dae, Cheong Sun Hee, Kwon Ki Han, Anti-cancer effects of traditional Korean wild vegetables in complementary and alternative medicine, Complementary Therapies in Medicine, 24, 2016. Crossref

  16. Shanmugam Muthu K, Lee Jong Hyun, Chai Edna Zhi Pei, Kanchi Madhu Mathi, Kar Shreya, Arfuso Frank, Dharmarajan Arunasalam, Kumar Alan Prem, Ramar Perumal Samy, Looi Chung Yeng, Mustafa Mohammad Rais, Tergaonkar Vinay, Bishayee Anupam, Ahn Kwang Seok, Sethi Gautam, Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds, Seminars in Cancer Biology, 40-41, 2016. Crossref

676 文章浏览量 17 文章下载 统计数据
676 文章浏览量 17 下载次数 16 Crossref 引用次数 Google
Scholar
引用次数

相似内容的文章:

Effect of Amentoflavone, a Phenolic Component From Biophytum sensitivum, on Cell Cycling and Apoptosis of B16F-10 Melanoma Cells Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 4
K.S. Siveen , Girija Kuttan
Eupatilin, a Pharmacologically Active Flavone Derived from Artemisia Plants, Induces Apoptosis in Human Gastric Cancer (AGS) Cells Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 4
Tae Young Oh, Min-Jung Kim, Do-Hee Kim, Hye-Kyung Na, Young-Joon Surh, Chang-Yell Shin
Braf Mutations Are Associated With High Levels of Phosphorylated RKIP in Melanoma Cell Lines: Potential Prognostic Significance Onco Therapeutics, Vol.2, 2011, issue 2
S. Ekmekcioglu, Sara Huerta-Yepez, C. M. Rivera-Pazos, Elizabeth A. Grimm, Mario I. Vega, G. Antonio-Andres, G. Baay-Guzman
Ipobscurine, an Indole Alkaloid from Ipomoea obscura, Inhibits Tumor Cell Invasion and Experimental Metastasis by Inducing Apoptosis Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 2
T. P. Hamsa, Girija Kuttan
Induction of Apoptosis and Chemosensitization by the Histone Deacetylase Inhibitor Trichostatin in Hepatocellular Carcinoma Cells: Molecular Analysis and RKIP Levels Onco Therapeutics, Vol.2, 2011, issue 2
Luigi Inguglia, Manuela Labbozzetta, Paola Poma, Monica Notarbartolo, Natale D'Alessandro
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain